disease

Sarcopenia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Sarcopenia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

242Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	MITOPHAGY, MITOCHONDRIAL DYSFUNCTION, AGING, NEURODEGENERATION, CANCER, OVERVIEW, ALZHEIMER, ALZHEIMER'S DISEASE
Therapeutic Agents	Polygonatum sibiricum polysaccharide, Polygonatum Sibiricum Polysaccharide
KG Connections	220 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Sarcopenia["Sarcopenia"] -->|"causes"| Muscle_Mass_Loss["Muscle Mass Loss"]
    Sarcopenia["Sarcopenia"] -->|"associated"| Aging["Aging"]
    Sarcopenia["Sarcopenia"] -->|"therapeutic target"| Inflammation["Inflammation"]
    Sarcopenia["Sarcopenia"] -->|"activates"| Nf__b["Nf-Kappab"]
    Sarcopenia["Sarcopenia"] -->|"activates"| Autophagy["Autophagy"]
    Sarcopenia["Sarcopenia"] -->|"associated"| Mitophagy["Mitophagy"]
    Muscle_Strength_Loss["Muscle Strength Loss"] -->|"associated"| Sarcopenia["Sarcopenia"]
    Presarcopenia["Presarcopenia"] -->|"risk factor for"| Sarcopenia["Sarcopenia"]
    Extracellular_Vesicles["Extracellular Vesicles"] -->|"biomarker for"| Sarcopenia["Sarcopenia"]
    EXERCISE["EXERCISE"] -->|"therapeutic target"| Sarcopenia["Sarcopenia"]
    style Sarcopenia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (73)

Target	Relation	Type	Str
Muscle Mass Loss	causes	phenotype	0.95
Muscle Strength Loss	causes	phenotype	0.95
Muscle Mass	associated_with	phenotype	0.90
Muscle Strength	associated_with	phenotype	0.90
Muscle Function	associated_with	phenotype	0.90
Chronic Inflammation	associated_with	process	0.90
Frailty	contributes_to	disease	0.90
Frailty	associated_with	disease	0.90
Extracellular Vesicles	associated_with	organelle	0.85
Morbidity	causes	phenotype	0.85
Mortality	causes	phenotype	0.85
Aging	associated_with	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Nf-Κb	activates	pathway	0.70
Autophagy	activates	pathway	0.70
Mitophagy	associated_with	pathway	0.70
Mitochondrial Function	therapeutic_target	pathway	0.70
Als	therapeutic_target	disease	0.65
Insulin Resistance	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
Pi3K/Akt	therapeutic_target	pathway	0.60
Differentiation	treats	pathway	0.60
Mtor	therapeutic_target	pathway	0.60
Oxidative Stress	treats	pathway	0.60
Mitochondrial Function	associated_with	pathway	0.60
Mitophagy	implicated_in	pathway	0.60
Differentiation	activates	pathway	0.60
Microbiota	therapeutic_target	pathway	0.60
Oxidative Stress	regulates	pathway	0.60
Apoptosis	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
Synaptic Plasticity	activates	pathway	0.60
Epigenetic	associated_with	pathway	0.60
Oxidative Stress	therapeutic_target	pathway	0.60
Mitochondrial Function	treats	pathway	0.60
Stem Cell	therapeutic_target	pathway	0.60
Microrna	therapeutic_target	pathway	0.60
Apoptosis	therapeutic_target	pathway	0.60
Oxidative Stress	implicated_in	pathway	0.60
Autophagy	implicated_in	pathway	0.60
Mitochondrial Function	implicated_in	pathway	0.60
Aging	treats	disease	0.55
Als	treats	disease	0.55
Aging	implicated_in	disease	0.55
Als	implicated_in	disease	0.55
Neurodegeneration	associated_with	disease	0.55
Cachexia	therapeutic_target	disease	0.55
Aging	inhibits	disease	0.55
Inflammation	activates	disease	0.55
Alzheimer	activates	disease	0.55

Incoming (169)

Source	Relation	Type	Str
Muscle Strength Loss	associated_with	phenotype	0.95
Muscle Atrophy	associated_with	phenotype	0.95
Functional Decline	associated_with	phenotype	0.95
Type 2 Diabetes Mellitus	causes	disease	0.95
T2DM	associated_with	disease	0.95
Type 2 Diabetes Mellitus	associated_with	disease	0.95
T2DM	causes	disease	0.95
Presarcopenia	risk_factor_for	disease	0.90
Muscle Strength Loss	contributes_to	phenotype	0.90
Polygonatum Sibiricum Polysaccharide	treats	compound	0.90
Aging	risk_factor_for	process	0.90
Ageing	associated_with	process	0.90
Extracellular Vesicles	biomarker_for	biomarker	0.85
EXERCISE	therapeutic_target	gene	0.85
AMPK	activates	gene	0.85
AGING	associated_with	gene	0.85
INFLAMMATION	therapeutic_target	gene	0.85
IRISIN	treats	protein	0.85
Polygonatum sibiricum polysaccharide	treats	compound	0.85
Presarcopenia	associated_with	disease	0.85
Muscle Mass Loss	involved_in	phenotype	0.85
Iron Overload	contributes_to	phenotype	0.85
extracellular matrix remodeling	involved_in	process	0.85
Physical Activity	protects_against	process	0.85
Monocyte/Macrophage Subsets	associated_with	cell_type	0.80
MTOR	regulates	pathway	0.80
Chronic Inflammation	contributes_to	process	0.80
immune cell phenotypes	biomarker_for	phenotype	0.80
Glycaemic Control	modulates	mechanism	0.80
CD206	biomarker_for	biomarker	0.75
NF-ΚB	activates	gene	0.75
AGING	implicated_in	gene	0.75
MITOPHAGY	associated_with	gene	0.75
AUTOPHAGY	activates	gene	0.75
NAD	therapeutic_target	gene	0.75
INSULIN RESISTANCE	activates	gene	0.75
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.75
ALZHEIMER	associated_with	gene	0.75
Immune Cell Phenotypes	associated_with	cell_type	0.75
CD68	biomarker_for	protein	0.75
COPD	associated_with	disease	0.70
Extracellular Matrix Remodeling	associated_with	process	0.70
Hyperglycemia	contributes_to	biological_process	0.70
MYOD	treats	gene	0.65
ROS	treats	gene	0.65
OXIDATIVE STRESS	treats	gene	0.65
PI3K	therapeutic_target	gene	0.65
P53	treats	gene	0.65
MITOCHONDRIAL DYSFUNCTION	treats	gene	0.65
PSP	therapeutic_target	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Sarcopenia

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

nct07165106

Paraventricular Hypothalamic Nucleus (PVN) Neurons

Mediterranean and MIND Diets for Neurodegeneration

Liver-Brain Neurodegeneration Axis

Urolithin A for Neurodegeneration

PPP1R15B

MSA Treatment Approaches and Emerging Therapies

Tsumura & Co.

Mitochondrial Dysfunction in ALS-FTD Spectrum

Sword Health

withings

Physical Exercise Therapy for Parkinson's Disease

MYH8 (Myosin Heavy Chain 8)

Serum Amino Acid Biomarkers for Brain Hypometabolism

Amino Acid Supplementation in Parkinson's Disease

Urolithin A for Parkinson's Disease (MUSIC Trial NCT06033890)

Dietary Interventions for Parkinson's Disease