concept

IRF8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRF8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

76Connections

0Hypotheses

0Analyses

50Outgoing

22Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	IRF8
Key Genes/Proteins	IFNG, C4B, TREM2, MICROGLIA
Related Diseases	Reactive Microglia, Alzheimer, Atherosclerosis, Lymphoma, Als
Related Pathways	Myelination

Wiki Pages (11)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IRF8["IRF8"]
    IRF8 -->|"activates"| Atherosclerosis["Atherosclerosis"]
    IRF8 -->|"activates"| Lymphoma["Lymphoma"]
    IRF8 -->|"regulates"| Als["Als"]
    IRF8 -->|"regulates"| ALS["ALS"]
    IRF8 -->|"regulates"| microglia["microglia"]
    IRF8 -->|"regulates"| IFNG["IFNG"]
    IRF8 -->|"causes"| MICROGLIA["MICROGLIA"]
    IRF8 -->|"activates"| APOPTOSIS["APOPTOSIS"]
    S1PR1["S1PR1"] -->|"upregulates"| IRF8
    S1P1["S1P1"] -->|"upregulates"| IRF8
    IL_10["IL-10"] -->|"activates"| IRF8
    AKT["AKT"] -->|"activates"| IRF8
    LDL["LDL"] -->|"activates"| IRF8
    MAF["MAF"] -->|"activates"| IRF8
    ATP["ATP"] -->|"activates"| IRF8
    MAPK["MAPK"] -->|"activates"| IRF8

Outgoing (54)

Target	Relation	Type	Str
Reactive Microglia	regulates	phenotype	0.80
microglia	expressed_in	cell_type	0.70
Alzheimer	associated_with	disease	0.65
Atherosclerosis	activates	disease	0.65
Lymphoma	activates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
Encephalitis	associated_with	disease	0.65
microglia	regulates	cell_type	0.60
IFNG	regulates	gene	0.60
C4B	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
MICROGLIA	causes	gene	0.60
Myelination	associated_with	pathway	0.60
APOPTOSIS	activates	gene	0.60
MERTK	activates	gene	0.60
Mapk	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Sphingolipid	activates	pathway	0.60
Mtor	activates	pathway	0.60
AKT	activates	gene	0.60
MAPK	activates	gene	0.60
LDL	activates	gene	0.60
IL-10	activates	gene	0.60
Cholesterol	activates	pathway	0.60
Macrophage	activates	cell_type	0.60
IFN	regulates	gene	0.60
RNA	regulates	gene	0.60
Microglia	regulates	cell_type	0.60
IFN-Γ	regulates	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
RNA	associated_with	gene	0.60
AND	associated_with	gene	0.60
AND	activates	gene	0.60
MAF	activates	gene	0.60
MTOR	activates	gene	0.60
B Cell	activates	cell_type	0.60
Interferon	activates	protein	0.60
Interferon	regulates	protein	0.60
Il-1	activates	protein	0.60
apoptosis pathway	participates_in	pathway	0.60
macrophages	expressed_in	cell_type	0.60
MAPK signaling	participates_in	pathway	0.60
neuroinflammation	activates	disease	0.60
LXR	activates	gene	0.60
PKA	activates	gene	0.60
T Cell	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55

Incoming (22)

Source	Relation	Type	Str
S1P1	upregulates	receptor	0.85
ASTROCYTE	associated_with	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
RNA	associated_with	gene	0.60
JUN	associated_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
IL-10	activates	gene	0.60
AKT	activates	gene	0.60
LDL	activates	gene	0.60
MAF	activates	gene	0.60
ATP	activates	gene	0.60
MAPK	activates	gene	0.60
AND	activates	gene	0.60
MTOR	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
RNA	regulates	gene	0.60
AND	regulates	gene	0.60
IFN	regulates	gene	0.60
MERTK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IRF8

Understanding Entity Pages

Wiki Pages (11)

Microglia Activation Mechanism

TLR5-Mediated Microglial Neuroinflammation Hypothesis

SPI1 Gene - PU.1

Epigenetic Biomarkers in Neurodegenerative Diseases

TLR5 Gene

TMEM119 — Transmembrane Protein 119

PU.1 Protein (SPI1)

IFNG Gene

CNS Border-Associated Macrophages (BAMs)