concept

NR3C2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR3C2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

38Outgoing

34Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	NR3C2
Key Genes/Proteins	TNF, CYTOKINES, CRHR1, CRH, POMC, JUN
Related Diseases	Tumor, ALS, Als, Depression, Anxiety
Related Pathways	Hypothalamic-Pituitary-Adrenal Axis

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NR3C2["NR3C2"]
    NR3C2 -->|"regulates"| Hypothalamic_Pituitary_Adrenal["Hypothalamic-Pituitary-Adrenal Axis"]
    NR3C2 -->|"expressed in"| Tumor["Tumor"]
    NR3C2 -->|"activates"| ALS["ALS"]
    NR3C2 -->|"activates"| Als["Als"]
    NR3C2 -->|"regulates"| Depression["Depression"]
    NR3C2 -->|"regulates"| Anxiety["Anxiety"]
    NR3C2 -->|"expressed in"| TNF["TNF"]
    NR3C2 -->|"activates"| CYTOKINES["CYTOKINES"]
    IL12["IL12"] -->|"expressed in"| NR3C2
    ESR2["ESR2"] -->|"expressed in"| NR3C2
    AVP["AVP"] -->|"expressed in"| NR3C2
    ESR1["ESR1"] -->|"expressed in"| NR3C2
    CRH["CRH"] -->|"expressed in"| NR3C2
    TNF -->|"expressed in"| NR3C2
    JUN["JUN"] -->|"activates"| NR3C2
    NR3C1["NR3C1"] -->|"expressed in"| NR3C2

Outgoing (38)

Target	Relation	Type	Str
Hypothalamic-Pituitary-Adrenal Axis	regulates	pathway	0.85
Hypothalamic-Pituitary-Adrenal Axis	involved_in	pathway	0.75
Tumor	expressed_in	disease	0.65
ALS	activates	disease	0.65
Als	activates	disease	0.65
Depression	regulates	disease	0.65
Anxiety	regulates	disease	0.65
TNF	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
CRHR1	expressed_in	gene	0.60
CRH	expressed_in	gene	0.60
POMC	expressed_in	gene	0.60
JUN	activates	gene	0.60
NR3C1	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
AVP	expressed_in	gene	0.60
ESR1	expressed_in	gene	0.60
Immune Response	activates	pathway	0.60
Er Stress	activates	pathway	0.60
ESR2	expressed_in	gene	0.60
IL6	regulates	gene	0.60
Neuron	regulates	cell_type	0.60
DEPRESSION	regulates	gene	0.60
NR3C1	activates	gene	0.60
AND	activates	gene	0.60
NOD2	activates	gene	0.60
TNFA	activates	gene	0.60
IL12	expressed_in	gene	0.60
Interleukin	expressed_in	protein	0.60
Cytokine	activates	protein	0.60
Raf	activates	protein	0.60
Rb	activates	protein	0.60
Ras	regulates	protein	0.60
neurodegeneration	causes	disease	0.60
Prefrontal Cortex	expressed_in	brain_region	0.55
Cortex	expressed_in	brain_region	0.55
Hippocampus	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (34)

Source	Relation	Type	Str
IL12	expressed_in	gene	0.60
ESR2	expressed_in	gene	0.60
AVP	expressed_in	gene	0.60
ESR1	expressed_in	gene	0.60
CRH	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
JUN	activates	gene	0.60
NR3C1	expressed_in	gene	0.60
DEPRESSION	regulates	gene	0.60
NOD2	activates	gene	0.60
TNF	activates	gene	0.60
TNFA	activates	gene	0.60
IL6	regulates	gene	0.60
ANXIETY	regulates	gene	0.60
GENES	regulates	gene	0.60
POMC	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
CRHR1	expressed_in	gene	0.60
CYTOKINES	activates	gene	0.60
BDNF	activates	gene	0.60
CNR1	activates	gene	0.60
DRD1	activates	gene	0.60
GABA	activates	gene	0.60
MC4R	activates	gene	0.60
NLRP3	activates	gene	0.60
BDNF	causes	gene	0.60
CNR1	causes	gene	0.60
DRD1	causes	gene	0.60
GABA	causes	gene	0.60
MC4R	causes	gene	0.60
NLRP3	causes	gene	0.60
GR	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
DLG2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NR3C2

Understanding Entity Pages

Wiki Pages (7)

Glucocorticoid Signaling Pathway in Neurodegeneration

cortisol-tau-pathway

Hypothalamic-Pituitary-Adrenal Axis

HPA Axis Neurons in Neurodegeneration

Bed Nucleus of Stria Terminalis in Stress