concept

AMYLOID BETA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID BETA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

713Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	AMYLOID BETA
Key Genes/Proteins	TRKB, APP
Related Diseases	Alzheimer's Disease, Alzheimer Disease, Parkinson's Disease with Dementia

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    AMYLOID_BETA["<b>AMYLOID BETA</b>"]
    AMYLOID_BETA -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    AMYLOID_BETA -->|"binds"| Microglia["Microglia"]
    AMYLOID_BETA -->|"activates"| Microglial_Activation["Microglial Activation"]
    AMYLOID_BETA -->|"contributes to"| MAP1LC3B["MAP1LC3B"]
    AMYLOID_BETA -->|"contributes to"| SQSTM1["SQSTM1"]
    AMYLOID_BETA -->|"activates"| astrocytes["astrocytes"]
    AMYLOID_BETA -->|"regulates"| autophagy["autophagy"]
    AMYLOID_BETA -->|"causes"| reactive_astrocytes["reactive astrocytes"]
    AMYLOID_BETA -->|"activates"| Autophagy["Autophagy"]
    MAP1LC3B -->|"inhibits"| AMYLOID_BETA
    SQSTM1 -->|"inhibits"| AMYLOID_BETA
    Autophagy -->|"targets"| AMYLOID_BETA
    Intramural_Periarterial_Draina["Intramural Periarterial Drainage"] -->|"involved_in"| AMYLOID_BETA
    Glymphatic_Pathway["Glymphatic Pathway"] -->|"mediates"| AMYLOID_BETA
    Dam["Dam"] -->|"interacts"| AMYLOID_BETA
    SCARA1["SCARA1"] -->|"binds"| AMYLOID_BETA
    AGER["AGER"] -->|"binds"| AMYLOID_BETA
    Lysosomes["Lysosomes"] -->|"involved_in"| AMYLOID_BETA
    CD36["CD36"] -->|"binds"| AMYLOID_BETA
    FPR2["FPR2"] -->|"binds"| AMYLOID_BETA

Outgoing (277)

Target	Relation	Type	Str
Alzheimer's Disease	biomarker_for	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.95
Alzheimer's Disease	associated_with	disease	0.95
Alzheimer Disease	involved_in	disease	0.95
Microglia	activates	cell_type	0.95
Neuroinflammation	causes	process	0.95
Parkinson's Disease with Dementia	associated_with	disease	0.95
Alzheimer's Disease	causes	disease	0.90
Microglia Activation	activates	process	0.90
Central Neuroinflammation	causes	process	0.90
Retina	expressed_in	cell_type	0.90
Oxidative Stress	causes	process	0.90
TRKB	degrades	protein	0.90
Synaptic Structure	modulates	phenotype	0.88
Synaptic Plasticity	inhibits	process	0.88
Chronic Neuroinflammation	causes	process	0.85
Alzheimer's Disease Progression	associated_with	process	0.85
Neuronal Apoptosis	causes	process	0.85
Insulin Resistance	contributes_to	process	0.85
Tau Pathology	causes	process	0.85
MAPT	associated_with	protein	0.80
Mitophagy	inhibits	process	0.80
NEURODEGENERATION	causes	disease	0.80
Alzheimer's disease	causes	disease	0.80
Redox Imbalance	causes	process	0.75
INSULIN RESISTANCE	inhibits	process	0.50
NEUROINFLAMMATION	inhibits	process	0.50
AUTOPHAGY	associated_with	process	0.50
MICROGLIA	interacts_with	cell_type	0.50
ASTROCYTES	interacts_with	cell_type	0.50
PHAGOCYTOSIS	associated_with	process	0.50
ASTROCYTES	associated_with	cell_type	0.50
ALZHEIMER'S DISEASE	associated_with	disease	0.50
ALZHEIMER	associated_with	disease	0.50
NEURODEGENERATION	biomarker_for	process	0.50
INFLAMMATION	biomarker_for	process	0.50
NEUROINFLAMMATION	associated_with	process	0.50
MITOCHONDRIAL DYSFUNCTION	activates	process	0.50
ALZHEIMER'S DISEASE	upregulates	disease	0.50
ALZHEIMER	upregulates	disease	0.50
PHAGOCYTOSIS	upregulates	process	0.50
AUTOPHAGY	activates	process	0.50
RAPAMYCIN	activates	drug	0.50
PARKINSON'S DISEASE	associated_with	disease	0.50
PARKINSON	associated_with	disease	0.50
DEMENTIA	associated_with	disease	0.50
ALZHEIMER	inhibits	disease	0.50
NEURODEGENERATION	associated_with	process	0.50
OXIDATIVE STRESS	associated_with	process	0.50
ALZHEIMER'S DISEASE	biomarker_for	disease	0.50

Incoming (436)

Source	Relation	Type	Str
Γ-SECRETASE	cleaves	enzyme	0.95
APP	product_of	protein	0.90
Glymphatic System	transports	pathway	0.90
Tirzepatide	inhibits	drug	0.85
APP	regulates	entity	0.85
Defective Insulin Signaling	upregulates	process	0.85
Oxidative Stress	upregulates	process	0.80
Mitochondrial Dysfunction	upregulates	process	0.80
Hyperbaric Oxygen Therapy	targets	drug	0.80
IDE	degrades	protein	0.80
TAU	inhibits	protein	0.50
TAU	interacts_with	protein	0.50
TREM2	associated_with	gene	0.50
TAU	biomarker_for	protein	0.50
TAU	associated_with	protein	0.50
TAU	activates	protein	0.50
CREB	activates	gene	0.50
DRP1	activates	gene	0.50
APP	activates	gene	0.50
PSEN1	activates	gene	0.50
PSEN2	activates	gene	0.50
MTOR	activates	gene	0.50
AMPK	activates	gene	0.50
TFEB	activates	gene	0.50
RAS	activates	gene	0.50
BCL2	activates	gene	0.50
BECN1	activates	gene	0.50
ULK1	activates	gene	0.50
LAMP2	activates	gene	0.50
HUNTINGTIN	associated_with	protein	0.50
ALPHA-SYNUCLEIN	associated_with	protein	0.50
HMGB1	activates	gene	0.50
AMYLOID	associated_with	gene	0.50
PARKINSON	associated_with	gene	0.50
DEMENTIA	associated_with	gene	0.50
Parkinson's Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
PARKINSON'S	associated_with	concept	0.50
AMBRA1	activates	protein	0.50
Autophagy	activates	process	0.50
CTSD	activates	gene	0.50
UVRAG	activates	gene	0.50
GABA	activates	gene	0.50
mTOR	activates	entity	0.50
BCL2L1	activates	gene	0.50
MAP1LC3B	activates	gene	0.50
ESR1	activates	gene	0.50
WDR45	activates	gene	0.50
PIK3C3	activates	gene	0.50
ESR2	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AMYLOID BETA

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

CBS/PSP Supplements Guide

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

nhp-validation-animal-model

Neuroresilience Mechanisms and Evidence

NPM1 Gene

PI-2620 Tau PET in PSP

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

GRIA3 Gene

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy