concept

EEA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EEA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections

0Hypotheses

1Analyses

37Outgoing

22Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	EEA1
Key Genes/Proteins	MTORC1, DMSO, AKT, LYSOSOMAL BIOGENESIS, AUTOPHAGY, TFEB
Related Diseases	Ms
Related Pathways	Autophagy, Mtor, Akt, Endocytosis

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    EEA1["EEA1"]
    EEA1 -->|"activates"| MTORC1["MTORC1"]
    EEA1 -->|"activates"| AKT["AKT"]
    EEA1 -->|"activates"| LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"]
    EEA1 -->|"activates"| AUTOPHAGY["AUTOPHAGY"]
    EEA1 -->|"activates"| Autophagy["Autophagy"]
    EEA1 -->|"activates"| Akt["Akt"]
    EEA1 -->|"activates"| Endocytosis["Endocytosis"]
    EEA1 -->|"activates"| TFEB["TFEB"]
    ENDOSOMES["ENDOSOMES"] -->|"activates"| EEA1
    TFEB -->|"activates"| EEA1
    AND["AND"] -->|"activates"| EEA1
    TSC2["TSC2"] -->|"activates"| EEA1
    GENES["GENES"] -->|"activates"| EEA1
    AKT -->|"activates"| EEA1
    LYSOSOMAL_BIOGENESIS -->|"activates"| EEA1
    MTORC1 -->|"activates"| EEA1

Outgoing (37)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
MTORC1	activates	gene	0.60
DMSO	associated_with	gene	0.60
AKT	activates	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
Mtor	associated_with	pathway	0.60
Akt	activates	pathway	0.60
Endocytosis	activates	pathway	0.60
TFEB	activates	gene	0.60
AND	activates	gene	0.60
MTOR	associated_with	gene	0.60
EGF	associated_with	gene	0.60
ENDOSOMES	activates	gene	0.60
TSC2	activates	gene	0.60
MAP1LC3	associated_with	gene	0.60
LC3	associated_with	gene	0.60
GENES	activates	gene	0.60
GFP	associated_with	gene	0.60
EGF	interacts_with	gene	0.60
GFP	interacts_with	gene	0.60
LC3	interacts_with	gene	0.60
MAP1LC3	interacts_with	gene	0.60
MTOR	interacts_with	gene	0.60
oxidative stress response	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
SORL1	inhibits	gene	0.60
LAMP2	interacts_with	gene	0.60
MAP2	interacts_with	gene	0.60
RAS	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
Alzheimer's disease	interacts_with	disease	0.60
unfolded protein response	participates_in	pathway	0.55
astrocytes	expressed_in	cell_type	0.55
RAB5	co_discussed	gene	0.40
TAU	co_discussed	gene	0.40

Incoming (22)

Source	Relation	Type	Str
ENDOSOMES	activates	gene	0.60
MAP1LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
EGF	associated_with	gene	0.60
GFP	associated_with	gene	0.60
TFEB	activates	gene	0.60
AND	activates	gene	0.60
LC3	associated_with	gene	0.60
TSC2	activates	gene	0.60
GENES	activates	gene	0.60
AKT	activates	gene	0.60
LYSOSOMAL BIOGENESIS	activates	gene	0.60
MTORC1	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
DMSO	associated_with	gene	0.60
DMSO	interacts_with	gene	0.60
rapamycin	targets	drug	0.60
ABCB1	inhibits	gene	0.60
ATP	inhibits	gene	0.60
APP	interacts_with	gene	0.60
ATG	interacts_with	gene	0.60
CTSD	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

EEA1

Understanding Entity Pages

Wiki Pages (20)

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GDI2 Protein

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SPG15 Gene - Spastic Paraplegia 15

STX12 - Syntaxin 12

INPP4A Gene - Inositol Polyphosphate-4-Phosphatase Type I

RAB22A

Rab5 Protein

protein-trafficking-pathways

retromer-endosomal-sorting-parkinsons

BIN1→Endosomal Dysfunction→Tau Pathology→AD Causal Chain

RAB5A — Ras-Related Protein Rab-5A

RAB5C Gene — RAB5C, Member RAS Oncogene Family

Endosomal Trafficking Dysfunction: Cross-Disease Comparison

RAB5A Gene