ROCK1

Understanding Entity Pages

This page aggregates everything SciDEX knows about ROCK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

ROCK1 (Rho Associated Coiled-Coil Containing Protein Kinase 1) - serine/threonine kinase effector of Rho GTPases regulating cytoskeleton, cell adhesion, and synaptic plasticity. Implicated in AD, PD, ALS, and stroke.

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graph TD
    ROCK1["<b>ROCK1</b>"]
    TFEB["TFEB"]
    ROCK1 -->|"phosphorylates"| TFEB
    P62["P62"]
    ROCK1 -->|"co-localizes"| P62
    PRKCH["PRKCH"]
    ROCK1 -->|"regulates"| PRKCH
    Alzheimer{"Alzheimer"}
    ROCK1 -->|"regulates"| Alzheimer
    Neurodegeneration{"Neurodegeneration"}
    ROCK1 -->|"regulates"| Neurodegeneration
    Ms{"Ms"}
    ROCK1 -->|"regulates"| Ms
    Als{"Als"}
    ROCK1 -->|"activates"| Als
    Cancer{"Cancer"}
    ROCK1 -->|"activates"| Cancer
    Inflammation{"Inflammation"}
    ROCK1 -->|"activates"| Inflammation
    LAMP1["LAMP1"]
    ROCK1 -->|"expressed in"| LAMP1
    SQSTM1["SQSTM1"]
    ROCK1 -->|"expressed in"| SQSTM1
    RHOA["RHOA"]
    ROCK1 -->|"activates"| RHOA
    SQSTM1 -->|"co-localizes"| ROCK1
    APP_PS1["APP/PS1"]
    APP_PS1 -->|"inhibits"| ROCK1
    P62 -->|"expressed in"| ROCK1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"associated with"| ROCK1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| ROCK1
    LYSOSOMAL_BIOGENESIS["LYSOSOMAL BIOGENESIS"]
    LYSOSOMAL_BIOGENESIS -->|"regulates"| ROCK1
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| ROCK1
    LAMP1 -->|"expressed in"| ROCK1
    RHOA -->|"activates"| ROCK1
    APP["APP"]
    APP -->|"inhibits"| ROCK1
    SQSTM1 -->|"expressed in"| ROCK1
    TFEB -->|"regulates"| ROCK1
    style ROCK1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0