gene

IFNAR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IFNAR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

93Connections

0Hypotheses

1Analyses

50Outgoing

25Incoming

0Experiments

1Debates

Summary

Gene page for IFNAR1 - interferon alpha receptor 1 involved in type I interferon signaling, neuroinflammation, and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	IFNAR1
Full Name	Interferon Alpha Receptor 1
Aliases	Gene page for IFNAR1
Chromosome	21q22.11
Primary Expression	Ubiquitous (immune cells, neurons, astrocytes, microglia)
Amino Acids	557 aa
Exons	22
Pathways	Cgas-Sting, Complement, Immune Response, Jak-Stat, Microglia Activation
UniProt ID	P17181
NCBI Gene ID	3454
Ensembl ID	ENSG00000142149
OMIM	146590
GeneCards	IFNAR1
Human Protein Atlas	IFNAR1
IFNAR1	Ligand-binding chain with lower affinity
Associated Diseases	neurodegeneration
Interactions	AND, APOE, ASTROCYTES, C4B, CGAS, CGAS-STING
KG Connections	93 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IFNAR1 — AlphaFold P17181 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IFNAR1 — Interferon Alpha Receptor 1

gene · 1594 words

→

IFNAR1 Protein — Interferon Alpha Receptor 1

protein · 570 words

→

Pathway Diagram

graph TD
    IFNAR1["IFNAR1"]
    Inflammation{"Inflammation"}
    IFNAR1 -->|"activates"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    IFNAR1 -->|"activates"| Neuroinflammation
    Ms{"Ms"}
    IFNAR1 -->|"activates"| Ms
    Immune_Response(["Immune Response"])
    IFNAR1 -->|"activates"| Immune_Response
    CGAS["CGAS"]
    IFNAR1 -->|"activates"| CGAS
    neurodegeneration["neurodegeneration"]
    IFNAR1 -->|"implicated in"| neurodegeneration
    DSDNA["DSDNA"]
    DSDNA -->|"activates"| IFNAR1
    STING["STING"]
    STING -->|"activates"| IFNAR1
    CGAS -->|"activates"| IFNAR1
    GENES["GENES"]
    GENES -->|"activates"| IFNAR1
    DNA["DNA"]
    DNA -->|"activates"| IFNAR1
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| IFNAR1
    CGAS_STING["CGAS-STING"]
    CGAS_STING -->|"activates"| IFNAR1
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NEUROINFLAMMATION -->|"activates"| IFNAR1
    style IFNAR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (68)

Target	Relation	Type	Str
Inflammation	activates	disease	0.75
type I interferon response	regulates	pathway	0.70
Glaucoma	activates	disease	0.65
Depression	activates	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Anxiety	activates	disease	0.65
Diabetes	activates	disease	0.65
Prion Disease	expressed_in	disease	0.65
Autoimmune	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
neurodegeneration	associated_with	disease	0.60
STAT1	associated_with	gene	0.60
neuroinflammation	activates	disease	0.60
JAK	activates	gene	0.60
DNA	activates	gene	0.60
CGAS-STING	activates	gene	0.60
Jak-Stat	activates	pathway	0.60
Pyroptosis	activates	pathway	0.60
IFN	expressed_in	gene	0.60
ASTROCYTES	activates	gene	0.60
Stem Cell	activates	cell_type	0.60
Microglia	activates	cell_type	0.60
T Cell	activates	cell_type	0.60
Astrocyte	activates	cell_type	0.60
Interferon	activates	protein	0.60
TREM2	activates	gene	0.60
IFN	protects_against	gene	0.60
RNA	therapeutic_target	gene	0.60
Endothelial	protects_against	cell_type	0.60
Astrocyte	therapeutic_target	cell_type	0.60
CGAS	activates	gene	0.60
STING	activates	gene	0.60
C4B	activates	gene	0.60
STAT1	activates	gene	0.60
Phagocytosis	activates	pathway	0.60
Microglia Activation	activates	pathway	0.60
DSDNA	activates	gene	0.60
MICROGLIA	activates	gene	0.60
GENES	activates	gene	0.60
STAT1	regulates	gene	0.60
Cgas-Sting	activates	pathway	0.60
RNA	regulates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
TREM2	regulates	gene	0.60
MICROGLIA	expressed_in	gene	0.60
SYNAPSE	activates	gene	0.60
Microglia	expressed_in	cell_type	0.60

Incoming (25)

Source	Relation	Type	Str
CGAS	activates	gene	0.70
STING	activates	gene	0.60
HG	activates	gene	0.60
DEPRESSION	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
MICROGLIA	expressed_in	gene	0.60
IRF7	activates	gene	0.60
STING1	inhibits	gene	0.60
DSDNA	activates	gene	0.60
GENES	activates	gene	0.60
DNA	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
IFN	associated_with	gene	0.60
CGAS-STING	activates	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
SYNAPSE	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
SYNAPTIC PRUNING	activates	gene	0.60
RNA	expressed_in	gene	0.60
MICROGLIA	activates	gene	0.60
C4B	activates	gene	0.60
IFN	expressed_in	gene	0.60
ASTROCYTES	activates	gene	0.60
microglia	expressed_in	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What determines the specificity of TDP-43-induced mitochondrial DNA release for

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study establishes TDP-43 triggers mtDNA release via mPTP to activate c

closed · Rounds: 4 · Score: 0.73 · 2026-04-21

Related Research

Hypotheses and analyses mentioning IFNAR1 in their description or question text

No additional research found