gene

HRAS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HRAS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

261Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

HRAS is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, associated with. Associated with Als, Cancer, Cardiac. Connected to 102 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HRAS
Full Name	hras
Chromosome	11p15.5
Protein Type	Gene
Function	is a prototype member of the Ras family of small GTPases that functions as a molecular switch in intracellular signaling pathways.
Primary Expression	medium spiny neurons of the striatum and in dopaminergic neurons of the substantia nigra pars compacta
Amino Acids	188 aa
Exons	6
Pathways	NF-κB
UniProt ID	P01112
NCBI Gene ID	3265
Ensembl ID	ENSG00000174775
GeneCards	HRAS
Human Protein Atlas	HRAS
Associated Diseases	ALS, Cancer, Fibrosis, Inflammation, Ms
Interactions	GMM, RAGE, AKT, INFLAMMATION, IMMUNE INFILTRATION, GENES
KG Connections	261 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HRAS — AlphaFold P01112 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HRAS["HRAS"] -->|"therapeutic target"| Als["Als"]
    HRAS["HRAS"] -->|"therapeutic target"| Cardiac["Cardiac"]
    HRAS["HRAS"] -->|"therapeutic target"| Ms["Ms"]
    HRAS["HRAS"] -->|"therapeutic target"| Cancer["Cancer"]
    HRAS["HRAS"] -->|"regulates"| Als_1["Als"]
    HRAS["HRAS"] -->|"regulates"| Obesity["Obesity"]
    KCNH2["KCNH2"] -->|"therapeutic target"| HRAS["HRAS"]
    IDH1["IDH1"] -->|"therapeutic target"| HRAS["HRAS"]
    TP53["TP53"] -->|"therapeutic target"| HRAS["HRAS"]
    SCN5A["SCN5A"] -->|"therapeutic target"| HRAS["HRAS"]
    style HRAS fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (171)

Target	Relation	Type	Str
cancer	risk_factor_for	disease	0.95
cancer	causes	disease	0.95
Mapk	activates	pathway	0.90
Cancer	associated_with	disease	0.90
Cancer	therapeutic_target	disease	0.75
Mapk	therapeutic_target	pathway	0.70
KRAS	associated_with	gene	0.70
RAS	associated_with	gene	0.70
Als	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Obesity	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	expressed_in	disease	0.65
Fibrosis	causes	disease	0.65
Inflammation	causes	disease	0.65
Ulcerative Colitis	interacts_with	disease	0.65
Inflammation	interacts_with	disease	0.65
Aging	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Cardiac	activates	disease	0.65
Als	causes	disease	0.65
ALS	causes	disease	0.65
Depression	activates	disease	0.65
ALS	expressed_in	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
DRD2	therapeutic_target	gene	0.60
PPARG	therapeutic_target	gene	0.60
IDH2	therapeutic_target	gene	0.60
CASP3	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
CDK4	therapeutic_target	gene	0.60
CDKN1A	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
PPARG	regulates	gene	0.60
GAPDH	regulates	gene	0.60
REL	regulates	gene	0.60
FOXO1	regulates	gene	0.60
STAT1	associated_with	gene	0.60
NRAS	expressed_in	gene	0.60

Incoming (90)

Source	Relation	Type	Str
RAS	associated_with	protein	0.70
KCNH2	therapeutic_target	gene	0.60
IDH1	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
SCN5A	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
KCNQ1	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
CALM1	therapeutic_target	gene	0.60
LMNA	therapeutic_target	gene	0.60
MAPK3	therapeutic_target	gene	0.60
BCL2L1	therapeutic_target	gene	0.60
SRC	therapeutic_target	gene	0.60
CYCS	therapeutic_target	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
HSP90AA1	therapeutic_target	gene	0.60
MTOR	regulates	gene	0.60
IL6	regulates	gene	0.60
TP53	regulates	gene	0.60
MYC	regulates	gene	0.60
SOD2	regulates	gene	0.60
AKT	regulates	gene	0.60
HIF1A	regulates	gene	0.60
MAP2K1	associated_with	gene	0.60
IGF1	associated_with	gene	0.60
SRC	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
JAK2	associated_with	gene	0.60
MAPK1	associated_with	gene	0.60
MAPK14	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
KDR	associated_with	gene	0.60
PI3K	activates	gene	0.60
JAK2	therapeutic_target	gene	0.60
PIK3CG	therapeutic_target	gene	0.60
RHOA	therapeutic_target	gene	0.60
IGF1	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
NOS3	therapeutic_target	gene	0.60
PIK3R1	therapeutic_target	gene	0.60
NRAS	activates	gene	0.60
BRAF	activates	gene	0.60
NRAS	expressed_in	gene	0.60
AKT	causes	gene	0.60
MAPK3	causes	gene	0.60
PIK3R1	causes	gene	0.60
PIK3CA	causes	gene	0.60
EGFR	causes	gene	0.60
JAK2	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HRAS

Understanding Entity Pages

Summary

Wiki Pages (15)

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

PNMT Protein

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

RASA3 — Ras GTPase-Activating Protein 3

RASA1 — RAS p120 GTPase Activating Protein

RAF1 — RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-Raf)

MAPK3 Gene - ERK1

rasp

MAP2K1 Gene

MRAS — Muscle RAS Oncogene

Ras/Rap1 Signaling Neurons

MAPK/ERK Signaling Pathway in Neurodegeneration

NRAS Protein