protein

OGG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OGG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections

0Hypotheses

1Analyses

44Outgoing

23Incoming

0Experiments

1Debates

Summary

OGG1 is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with Aging, Als, Fibrosis. Connected to 51 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	OGG1
Chromosome	3p26.2<br>
Function	OGG1 is a bifunctional DNA glycosylase that both excises 8-oxoG from damaged DNA and cleaves the abasic site that remains.
Primary Expression	all brain regions with highest levels in: - Hippocampus (dentate gyrus, CA3) - Cerebral cortex (layer V pyramidal neuron
Molecular Weight	39 kDa
Pathways	Autophagy, Dna Repair, Mitophagy, Mtor, Oxidative Stress
UniProt ID	O15527
NCBI Gene ID	4967
Ensembl ID	ENSG00000114026
GeneCards	OGG1
Human Protein Atlas	OGG1
8-oxoG Removal	Primary enzyme for excising 8-oxoguanine lesions
AP Site Processing	Creates substrate for APE1 and DNA polymerase β
Mutagenesis Prevention	Prevents G:C to T:A transversions caused by 8-oxoG
Transcriptional Regulation	8-oxoG in promoters can affect gene expression
Associated Diseases	neurodegeneration, neuroinflammation
Interactions	AGING, AUTOPHAGY, Aβ42 oligomers, BDNF, BLM, DNA
KG Connections	67 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: OGG1 — AlphaFold O15527 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

OGG1 Gene

gene · 787 words

→

OGG1 Protein

protein · 1051 words

→

Pathway Diagram

graph TD
    OGG1["OGG1"]
    OGG1 -->|"activates"| Oxidative_Stress["Oxidative Stress"]
    OGG1 -->|"activates"| Mitophagy["Mitophagy"]
    OGG1 -->|"activates"| Pulmonary_Fibrosis["Pulmonary Fibrosis"]
    OGG1 -->|"activates"| Fibrosis["Fibrosis"]
    OGG1 -->|"activates"| Aging["Aging"]
    OGG1 -->|"activates"| Als["Als"]
    OGG1 -->|"activates"| Inflammation["Inflammation"]
    OGG1 -->|"activates"| BLM["BLM"]
    OGG1 -->|"activates"| MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"]
    OGG1 -->|"activates"| DNA["DNA"]
    PINK1["PINK1"] -->|"activates"| OGG1
    AUTOPHAGY["AUTOPHAGY"] -->|"activates"| OGG1
    MITOPHAGY["MITOPHAGY"] -->|"activates"| OGG1
    GAIN["GAIN"] -->|"target for"| OGG1
    OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"activates"| OGG1
    SDHA["SDHA"] -->|"activates"| OGG1
    MFN2["MFN2"] -->|"activates"| OGG1
    BDNF["BDNF"] -->|"activates"| OGG1
    INFLAMMATION["INFLAMMATION"] -->|"activates"| OGG1
    SOD2["SOD2"] -->|"inhibits"| OGG1

Outgoing (44)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:OGG1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Oxidative Stress	activates	pathway	0.70
Mitophagy	activates	pathway	0.70
oxidative stress response	participates_in	pathway	0.70
Aging	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	activates	disease	0.65
Pulmonary Fibrosis	activates	disease	0.65
neuroinflammation	targets	disease	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
DNA	activates	gene	0.60
Autophagy	activates	pathway	0.60
Dna Repair	activates	pathway	0.60
Dna Repair	inhibits	pathway	0.60
Mtor	activates	pathway	0.60
BLM	activates	gene	0.60
Nf-Κb	inhibits	pathway	0.60
PARKIN	activates	gene	0.60
neuroinflammation	associated_with	disease	0.60
neuroinflammation	inhibits	disease	0.60
microglia	expressed_in	cell_type	0.60
AGING	activates	gene	0.60
DNA	inhibits	gene	0.60
MITOPHAGY	activates	gene	0.60
neurodegeneration	associated_with	disease	0.60
EXERCISE	activates	gene	0.60
MTDNA	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
neurodegeneration	activates	disease	0.60
NF-ΚB	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
SIRT3	activates	gene	0.60
MFN1	activates	gene	0.60
TFAM	activates	gene	0.60
LONP1	activates	gene	0.60
TNF	inhibits	gene	0.60
SIRT1	activates	gene	0.60
VEGF	activates	gene	0.60
PINK1	activates	gene	0.60
OPA1	activates	gene	0.60
GPX1	expressed_in	gene	0.60
MTOR	activates	gene	0.60

Incoming (23)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:OGG1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
Aβ42 oligomers	inhibits	protein	0.70
GAIN	therapeutic_target	gene	0.60
SDHA	activates	gene	0.60
MFN2	activates	gene	0.60
BDNF	activates	gene	0.60
PINK1	activates	gene	0.60
NRF2	inhibits	gene	0.60
FNDC5	activates	gene	0.60
FOXO1	activates	gene	0.60
FIS1	activates	gene	0.60
SOD2	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
MUTYH	associated_with	gene	0.60
DNA	regulates	gene	0.60
DNA	associated_with	gene	0.60
DNA	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
MUTYH	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do oligodendrocytes require DNA repair enhancement or inhibition for neuroprotec

neurodegeneration | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate revealed conflicting therapeutic approaches - enhancing DNA repair ve

closed · Rounds: 4 · Score: 1.00 · 2026-04-20

Related Research

Hypotheses and analyses mentioning OGG1 in their description or question text

No additional research found