Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CIRCADIAN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CIRCADIAN |
| Linked Hypotheses | 9 hypotheses |
Knowledge base pages for this entity
graph TD
CIRCADIAN["CIRCADIAN"]
CIRCADIAN -->|"interacts"| Melatonin["Melatonin"]
CIRCADIAN ---|"co-discussed"| LIPID_METABOLISM["LIPID METABOLISM"]
CIRCADIAN ---|"co-discussed"| NEURON["NEURON"]
CIRCADIAN ---|"co-discussed"| NEURONS["NEURONS"]
CIRCADIAN ---|"co-discussed"| SLEEP["SLEEP"]
CIRCADIAN ---|"co-discussed"| STING["STING"]
Melatonin -->|"activates"| CIRCADIAN
ANGIOGENESIS["ANGIOGENESIS"] ---|"co-discussed"| CIRCADIAN
AKT["AKT"] ---|"co-discussed"| CIRCADIAN
ALZHEIMER["ALZHEIMER"] ---|"co-discussed"| CIRCADIAN
ALZHEIMER_S["ALZHEIMER'S"] ---|"co-discussed"| CIRCADIAN
ASTROCYTE["ASTROCYTE"] ---|"co-discussed"| CIRCADIAN| Target | Relation | Type | Str |
|---|---|---|---|
| LIPID METABOLISM | co_discussed | entity | 0.50 |
| NEURON | co_discussed | entity | 0.50 |
| NEURONS | co_discussed | entity | 0.50 |
| SLEEP | co_discussed | entity | 0.50 |
| STING | co_discussed | entity | 0.50 |
| HYPOTHALAMUS | co_discussed | entity | 0.50 |
| THALAMUS | co_discussed | entity | 0.50 |
| T CELL | co_discussed | entity | 0.50 |
| SIRT1 | co_discussed | entity | 0.50 |
| ENDOTHELIAL | co_discussed | entity | 0.50 |
| CYTOKINE | co_discussed | entity | 0.50 |
| MACROPHAGE | co_discussed | entity | 0.50 |
| ERK | co_discussed | entity | 0.50 |
| OCLN | co_discussed | entity | 0.50 |
| TNF | co_discussed | entity | 0.50 |
| DEPRESSION | co_discussed | entity | 0.50 |
| EPIGENETIC | co_discussed | entity | 0.50 |
| DOPAMINERGIC | co_discussed | entity | 0.50 |
| GABA | co_discussed | entity | 0.50 |
| GABAergic | co_discussed | entity | 0.50 |
| NEURODEGENERATION | co_discussed | entity | 0.50 |
| HUNTINGTON | co_discussed | entity | 0.50 |
| PARKINSON | co_discussed | entity | 0.50 |
| PARKINSON'S | co_discussed | entity | 0.50 |
| NEUROINFLAMMATION | co_discussed | entity | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ANGIOGENESIS | co_discussed | entity | 0.50 |
| AKT | co_discussed | entity | 0.50 |
| ALZHEIMER | co_discussed | entity | 0.50 |
| ALZHEIMER'S | co_discussed | entity | 0.50 |
| ASTROCYTE | co_discussed | entity | 0.50 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-12 | 0 hypotheses
neurodegeneration | 2026-04-11 | 0 hypotheses
neuropharmacology | 2026-04-10 | 0 hypotheses
chronobiology | 2026-04-08 | 0 hypotheses
neuroinflammation | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Heal [PMID:40588189] | Bishehsari F, Post Z, Swanson GR, Keshav | Gastroenterology | 2025 | 1 |
| From geroscience to precision geromedicine: Understanding and managing aging. [PMID:40250404] | Kroemer G, Maier AB, Cuervo AM, Gladyshe | Cell | 2025 | 1 |
| BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. [PMID:40269168] | Ruan W, Li T, Bang IH, Lee J, Deng W, Ma | Nature | 2025 | 1 |
| Obstructive sleep apnea syndrome, orexin, and sleep-wake cycle: The link with th [PMID:39864923] | Fernandes M, Liguori C | Handb Clin Neurol | 2025 | 1 |
| Combined effects of HCRTR1/2 gene variants and non-genetic factors on sleep-wake [PMID:40439868] | Zheng Z, Xue F, Wang H, Gu Q, Hu R, Li X | Pharmacol Rep | 2025 | 1 |
| Circadian disruption, clock genes, and metabolic health. [PMID:39007272] | Schrader LA, Ronnekleiv-Kelly SM, Hogene | J Clin Invest | 2024 | 1 |
| Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases. [PMID:39728504] | Hussain Y, Dar MI, Pan X | Metabolites | 2024 | 1 |
| Circadian rhythm regulates the function of immune cells and participates in the [PMID:38678017] | Zeng Y, Guo Z, Wu M, Chen F, Chen L | Cell Death Discov | 2024 | 1 |
| SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826] | He G, Zhang Y, Feng Y, Chen T, Liu M, Ze | J Cell Mol Med | 2024 | 1 |
| Biomarkers of aging for the identification and evaluation of longevity intervent [PMID:37657418] | Moqri M, Herzog C, Poganik JR, Biomarker | Cell | 2023 | 1 |
| BMAL1 involved in autophagy and injury of thoracic aortic endothelial cells of r [PMID:37086572] | Chunli Yang, Ziwei Deng, Qihang Zeng, Xi | Biochemical and biophysical re | 2023 | 1 |
| Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] | Calvier L, Herz J, Hansmann G | JACC Basic Transl Sci | 2022 | 1 |
| Clocks, cancer, and chronochemotherapy. [PMID:33384351] | Sancar A, Van Gelder RN | Science | 2021 | 1 |
| Genetic determinants of daytime napping and effects on cardiometabolic health. [PMID:33568662] | Dashti HS, Daghlas I, Lane JM, Huang Y, | Nat Commun | 2021 | 1 |
| Hypocretin/Orexin Receptor Pharmacology and Sleep Phases. [PMID:34052813] | Sun Y, Tisdale RK, Kilduff TS | Front Neurol Neurosci | 2021 | 1 |
| Improved T-cell Receptor Diversity Estimates Associate with Survival and Respons [PMID:33177107] | Bortone DS, Woodcock MG, Parker JS, Vinc | Cancer Immunol Res | 2021 | 1 |
| Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress di [PMID:33285346] | Cénat JM, Blais-Rochette C, Kokou-Kpolou | Psychiatry Res | 2021 | 1 |
| Circadian Clock Regulation on Lipid Metabolism and Metabolic Diseases. [PMID:32705594] | Pan X, Mota S, Zhang B | Adv Exp Med Biol | 2020 | 1 |
| Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Seque [PMID:32822576] | Maynard A, McCoach CE, Rotow JK, Harris | Cell | 2020 | 1 |