gene

FLCN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FLCN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

129Connections

0Hypotheses

0Analyses

50Outgoing

46Incoming

Summary

FLCN is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 72 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FLCN
Full Name	Folliculin
Aliases	BHD, FLCN1, MGC19765
Chromosome	17p11.2
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neurons and glia - Highest expression in: - Cerebral cortex - [Hippocampus](/brain-regions/hippocamp
Pathways	mTOR, mtor, AMPK, mTOR Signaling
UniProt ID	Q8IVG7
GeneCards	FLCN
Human Protein Atlas	FLCN
Entrez Gene ID	201163
FNIP1	FLCN-interacting protein, regulates metabolism
FNIP2	FLCN-interacting protein 2
mTOR	Part of mTORC1/2 complexes
AMPK	Energy sensing kinase
Associated Diseases	ALS, Kidney Cancer
Known Drugs/Compounds	rapamycin
Interactions	TFEB, CGAS, NOTCH1, NF1, C9ORF72, STING
KG Connections	129 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: FLCN — AlphaFold Q8IVG7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FLCN["FLCN"] -.->|"inhibits"| AMPK["AMPK"]
    FLCN["FLCN"] -->|"regulates"| Cancer["Cancer"]
    FLCN["FLCN"] -->|"regulates"| Tumor["Tumor"]
    FLCN["FLCN"] -->|"activates"| Als["Als"]
    FLCN["FLCN"] -->|"expressed in"| Glioblastoma["Glioblastoma"]
    FLCN["FLCN"] -->|"expressed in"| Als_1["Als"]
    mitochondrial_respiratory_chai["mitochondrial respiratory chain deficiency"] -->|"contributes to"| FLCN["FLCN"]
    AMPK_2["AMPK"] -->|"activates"| FLCN["FLCN"]
    FNIP1["FNIP1"] -->|"interacts"| FLCN["FLCN"]
    MTOR["MTOR"] -->|"regulates"| FLCN["FLCN"]
    style FLCN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (83)

Target	Relation	Type	Str
TFEB	inhibits	protein	0.95
TFE3	inhibits	protein	0.95
Birt-Hogg Dubé Renal Neoplasia Syndrome	risk_factor_for	disease	0.90
AMPK	inhibits	protein	0.90
Metabolic Stress Survival	modulates	phenotype	0.85
Kidney Cancer	causes	disease	0.80
MTOR	regulates	protein	0.80
AMPK Energy Sensing	regulates	mechanism	0.80
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Als	activates	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Cirrhosis	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Als	interacts_with	disease	0.65
Dementia	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
ALS	activates	disease	0.65
TFEB	activates	gene	0.60
TFEB	regulates	gene	0.60
CGAS	activates	gene	0.60
TFEB	interacts_with	gene	0.60
NOTCH1	activates	gene	0.60
NF1	activates	gene	0.60
C9ORF72	interacts_with	gene	0.60
STING	activates	gene	0.60
GABARAP	interacts_with	gene	0.60
MITF	activates	gene	0.60
TFE3	activates	gene	0.60
TBK1	activates	gene	0.60
MTOR	interacts_with	gene	0.60
TLR4	activates	gene	0.60
NOTCH3	activates	gene	0.60
SOD1	activates	gene	0.60
AKT	expressed_in	gene	0.60
MTOR	expressed_in	gene	0.60
FNIP1	activates	gene	0.60
TSC2	activates	gene	0.60
AMPK	activates	gene	0.60
Autophagy	inhibits	pathway	0.60
AMPK	interacts_with	gene	0.60
MTORC1	regulates	gene	0.60
AMPK	regulates	gene	0.60
Autophagy	regulates	pathway	0.60
Mtor	regulates	pathway	0.60
MTORC1	interacts_with	gene	0.60

Incoming (46)

Source	Relation	Type	Str
GABARAP	binds	protein	0.85
mitochondrial respiratory chain deficiency	contributes_to	phenotype	0.80
FNIP1	interacts_with	gene	0.60
MTOR	regulates	gene	0.60
ULK1	regulates	gene	0.60
TFE3	regulates	gene	0.60
MTOR	interacts_with	gene	0.60
TBK1	activates	gene	0.60
MITF	activates	gene	0.60
TFE3	activates	gene	0.60
STING	activates	gene	0.60
GABARAP	interacts_with	gene	0.60
MTOR	expressed_in	gene	0.60
TLR4	activates	gene	0.60
PI3K	expressed_in	gene	0.60
SOD2	activates	gene	0.60
AKT	expressed_in	gene	0.60
SOD1	activates	gene	0.60
NOTCH3	activates	gene	0.60
FIP200	interacts_with	gene	0.60
SMCR8	interacts_with	gene	0.60
WDR41	interacts_with	gene	0.60
CGAS	activates	gene	0.60
NOTCH1	activates	gene	0.60
TFEB	interacts_with	gene	0.60
AMPK	activates	gene	0.60
CANCER	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
CGAS-STING	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
CANCER	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	interacts_with	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
AND	inhibits	gene	0.60
AND	interacts_with	gene	0.60
LYSOSOME	activates	gene	0.60
RAS	interacts_with	gene	0.60
GENES	activates	gene	0.60
AND	activates	gene	0.60
GENES	expressed_in	gene	0.60
MTORC1	interacts_with	gene	0.60
DNA	activates	gene	0.60
rapamycin	targets	drug	0.60
TFEB	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FLCN

Understanding Entity Pages

Summary

Wiki Pages (9)

FLCN Gene

NPRL2 Gene

TMEM55B — Transmembrane Protein 55B

AMPK Protein

WDR41 Gene

FNIP1 Gene

Folliculin Protein