concept

MELATONIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MELATONIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

234Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MELATONIN
Key Genes/Proteins	LRP1, TAU, HDAC3, AQP4, CREB, FOXO1
Related Diseases	MITOPHAGY
Related Pathways	CREB/RCAN1, Nrf2
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MELATONIN["MELATONIN"]
    style MELATONIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    MELATONIN -->|"treats"| Sepsis_Induced_Acute_Kidney_In["Sepsis-Induced Acute Kidney Injury"]
    MELATONIN -->|"upregulates"| SOX2([SOX2])
    MELATONIN -->|"upregulates"| OCT4([OCT4])
    MELATONIN -->|"upregulates"| NANOG([NANOG])
    MELATONIN -->|"upregulates"| POU5F1([POU5F1])
    MELATONIN -.->|"protects against"| mitochondrial_dysfunction(mitochondrial dysfunction)
    MELATONIN -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
    MELATONIN -->|"activates"| Mitophagy["Mitophagy"]
    MELATONIN -.->|"biomarker for"| CIRCADIAN_RHYTHM["CIRCADIAN RHYTHM"]
    MELATONIN -->|"modulates"| Skin_Fibroblasts["/Skin Fibroblasts/"]
    Circadian_Clock_Genes["Circadian Clock Genes"] -->|"regulates"| MELATONIN
    Circadian["Circadian"] -->|"interacts"| MELATONIN
    RPL18A([RPL18A]) -->|"regulates"| MELATONIN

Outgoing (175)

Target	Relation	Type	Str
CIRCADIAN RHYTHM	biomarker_for	entity	0.90
OBSTRUCTIVE SLEEP APNEA SYNDROME	biomarker_for	entity	0.85
CREB/RCAN1	activates	pathway	0.80
Nrf2	activates	pathway	0.80
ENDOTHELIAL CELLS	activates	cell_type	0.70
LRP1	activates	gene	0.70
MITOPHAGY	treats	phenotype	0.70
TAU	phosphorylates	protein	0.70
MITOPHAGY	inhibits	phenotype	0.70
HDAC3	inhibits	gene	0.70
HDAC3	activates	gene	0.70
AQP4	activates	gene	0.70
AQP4	regulates	gene	0.70
CREB	regulates	gene	0.70
FOXO1	activates	gene	0.70
AMYLOID	treats	protein	0.70
ROS	activates	phenotype	0.70
APP	activates	gene	0.70
NEURODEGENERATION	interacts_with	phenotype	0.70
AMYLOID	inhibits	protein	0.70
TLR4	treats	gene	0.70
TLR4	activates	gene	0.70
FERROPTOSIS	protects_against	phenotype	0.70
SEPSIS	inhibits	disease	0.65
AUTOPHAGY	inhibits	phenotype	0.65
SEPSIS	protects_against	disease	0.65
ALZHEIMER	activates	disease	0.65
AMYLOID	protects_against	protein	0.65
IL6	inhibits	gene	0.65
SCHIZOPHRENIA	activates	disease	0.65
FOXO1	interacts_with	gene	0.65
AUTISM	treats	disease	0.65
AUTISM	activates	disease	0.65
SYNAPTIC PLASTICITY	inhibits	phenotype	0.65
MITOPHAGY	causes	phenotype	0.65
SIRT1	protects_against	gene	0.65
SIRT1	activates	gene	0.65
NEUROINFLAMMATION	treats	phenotype	0.65
MICROGLIA	regulates	cell_type	0.65
STROKE	protects_against	disease	0.65
NEURODEGENERATION	regulates	disease	0.65
SIRT1	regulates	gene	0.65
HIPPOCAMPUS	regulates	brain_region	0.65
ER STRESS	inhibits	phenotype	0.65
MICROGLIA	causes	cell_type	0.65
STROKE	treats	disease	0.65
SIRT1	treats	gene	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
NEUROINFLAMMATION	activates	phenotype	0.65
MICROGLIA	activates	cell_type	0.65

Incoming (59)

Source	Relation	Type	Str
NEURODEGENERATION	stabilizes	phenotype	0.70
AMYLOID	stabilizes	protein	0.70
APP	treats	gene	0.70
TAU	treats	protein	0.70
SEROTONIN	causes	phenotype	0.70
PINK1	treats	gene	0.65
STING	inhibits	gene	0.65
APP	stabilizes	gene	0.60
NEURON	targets	cell_type	0.60
ENDOTHELIAL CELLS	associated_with	cell_type	0.50
AMYLOID-BETA	associated_with	protein	0.50
SYNAPTIC LOSS	associated_with	phenotype	0.50
HIPPOCAMPUS	associated_with	brain_region	0.50
ASTROCYTES	associated_with	cell_type	0.50
PHAGOCYTOSIS	associated_with	phenotype	0.50
SCHIZOPHRENIA	associated_with	disease	0.50
BIPOLAR DISORDER	associated_with	disease	0.50
FERROPTOSIS	associated_with	phenotype	0.45
STEM CELLS	associated_with	cell_type	0.45
SORAFENIB	associated_with	drug	0.45
SYNAPTIC PLASTICITY	associated_with	phenotype	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
FIBROBLASTS	associated_with	cell_type	0.45
NEUROBLASTOMA	associated_with	disease	0.45
SENESCENCE	associated_with	phenotype	0.45
CARDIOMYOCYTES	associated_with	cell_type	0.45
NRF2 PATHWAY	associated_with	pathway	0.45
PRAMIPEXOLE	associated_with	drug	0.45
MEMANTINE	associated_with	drug	0.45
NICOTINAMIDE	associated_with	drug	0.45
ACSL4	associated_with	gene	0.45
FIBROSIS	associated_with	disease	0.45
DOPAMINE	associated_with	phenotype	0.45
GABA	associated_with	phenotype	0.45
AUTOPHAGY	associated_with	phenotype	0.45
CREB	associated_with	gene	0.45
EPITHELIAL CELLS	associated_with	cell_type	0.45
CYTOKINES	associated_with	phenotype	0.45
IL6	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.45
INFLAMMATION	associated_with	phenotype	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
PYROPTOSIS	associated_with	phenotype	0.45
CGAS-STING PATHWAY	associated_with	pathway	0.45
NECROPTOSIS	associated_with	phenotype	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
MACROPHAGE	associated_with	cell_type	0.45
DENTATE GYRUS	associated_with	brain_region	0.45
ACETYLCHOLINE	associated_with	phenotype	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circadian Glymphatic Rescue Therapy (Melatonin-focused)	0.546	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (17)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Prevalence of symptoms of depression, anxiety, insomnia, posttraumatic stress di [PMID:33285346]	Cénat JM, Blais-Rochette C, Kokou-Kpolou	Psychiatry Res	2021	1
Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Seque [PMID:32822576]	Maynard A, McCoach CE, Rotow JK, Harris	Cell	2020	1
The Ca(2+) Sensor SCaBP3/CBL7 Modulates Plasma Membrane H(+)-ATPase Activity and [PMID:30962395]	Yang Y, Wu Y, Ma L, Yang Z, Dong Q, Li Q	Plant Cell	2019	1
Sleep drives metabolite clearance from the adult brain. [PMID:24136970]	Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Th	Science	2013	1
Impact of preinterventional plaque composition and eccentricity on late-acquired [PMID:22936019]	Sato T, Kameyama T, Noto T, Nozawa T, In	Coron Artery Dis	2012	1
Melatonin Promotes the Synthesis and Secretion of Growth Hormone in the Adenohyp [PMID:41870323]	["Zheng Y", "Chen Q", "Guo H", "Zhang Y"	Journal of pineal research	2026	0
Screening natural raw materials and product development for improving insomnia b [PMID:41578474]	["Yue L", "Jiao Q", "Li J", "Lu Y", "Yi	Medicine	2026	0
Pharmacological modulation of MRAP2 protein on murine melatonin receptor signali [PMID:40510472]	Song W, Li Y, Xu H, Zhang Y, Liu L, Li Y	Frontiers in endocrinology	2025	0
Regulation of therapeutic protein release in response to circadian biomarkers. [PMID:41198646]	Franko N, Li S, Galvan S, Csorba Z, Teix	Nature communications	2025	0
Polymorphisms in MTNR1A (rs2119882) and CLOCK (rs1801260) genes are associated w [PMID:40705802]	Chi Y, Yang X, Deng D, Li P, Zhang Y	PloS one	2025	0
Finger friction with leather and seam of new and used softballs with and without [PMID:35678234]	["Kinoshita H"]	Sports biomechanics	2024	0
System-Level Strategies to Improve Home Dialysis: Policy Levers and Quality Init [PMID:37678234]	["Watnick S", "Blake P", "Mehrotra R", "	Clinical journal of the Americ	2023	0
Recommendations for risk minimization when using Janus kinase inhibitors for the [PMID:37345890]	["Wohlrab J", "Kegel T", "Gro\u00dfe R",	Journal der Deutschen Dermatol	2023	0
In Vitro Anticancer Activity of the Light Stable Zinc Isotope (64Zn) Compounds. [PMID:36456123]	["Novak P", "Balakin A", "Temnik M"]	Anticancer research	2022	0
A long-term follow-up study on otoacoustic emissions testing in paediatric patie [PMID:31234890]	["Reiterer E", "Reider S", "Lackner P",	Malaria journal	2019	0
Severe refractory idiopathic warm autoimmune haemolytic anaemia responsive to co [PMID:30567234]	["Neave L", "Wilson A", "Lissack M", "Sc	BMJ case reports	2018	0
Metformin and lung cancer risk in patients with type 2 diabetes mellitus. [PMID:28456789]	["Tseng C"]	Oncotarget	2017	0

MELATONIN

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

CBS/PSP Rehabilitation Master Guide

PD Combination Therapy Matrix

Therapeutics

CBS/PSP Treatment Rankings

Circadian Rhythm in Neurodegeneration

Synucleinopathy Mechanism

Huntington's Disease

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Vascular Cognitive Impairment (VCI)

protective-strategies-cbs-psp

Sulforaphane and Nrf2 Activation for Neuroprotection