gene

SOX2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOX2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

555Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Comprehensive page on SOX2 transcription factor in neural stem cells and neurodegeneration

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🧬 Gene Info

Gene Symbol	SOX2
Full Name	SRY-Box Transcription Factor 2
Chromosome	3q26.33
Protein Type	Transcription Factor
Function	The SOX2 protein forms homodimers or heterodimers with other SOX proteins to bind specific DNA sequences (AACAAT/G) and regulate gene expression.
Primary Expression	Neural stem cells, neural progenitors, specific mature neurons
Molecular Weight	34 kDa
Amino Acids	80 aa
Pathways	Alzheimer's Disease Pathogenesis, Autophagy, Cell Cycle, Circadian Rhythm, Epigenetic
UniProt ID	P35745
NCBI Gene ID	6657
Ensembl ID	ENSG00000104946
OMIM	184429
GeneCards	SOX2
Human Protein Atlas	SOX2
Associated Diseases	ALS, Alzheimer'S Disease, Inflammation, Ms, Senescence
Interactions	POU5F1, KLF4, IL6, STAT3, SRC, GFAP
KG Connections	553 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SOX2 — AlphaFold P35745 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SOX2["SOX2"]
    SOX2 -->|"interacts"| PARP1["PARP1"]
    SOX2 -->|"interacts"| PARP2["PARP2"]
    SOX2 -->|"interacts"| PRKDC["PRKDC"]
    SOX2 -->|"interacts"| XRCC1["XRCC1"]
    SOX2 -->|"interacts"| XRCC5["XRCC5"]
    SOX2 -->|"interacts"| XRCC6["XRCC6"]
    SOX2 -->|"interacts"| RPA1["RPA1"]
    SOX2 -->|"interacts"| LIG3["LIG3"]
    SOX2 -->|"interacts"| DDB1["DDB1"]
    SOX2 -->|"activates"| Cancer["Cancer"]
    LIFR["LIFR"] -->|"upregulates"| SOX2
    YAP["YAP"] -->|"activates"| SOX2
    POU5F1["POU5F1"] -->|"activates"| SOX2
    FGFR1["FGFR1"] -->|"target for"| SOX2
    KLF4["KLF4"] -->|"activates"| SOX2
    IL6["IL6"] -->|"activates"| SOX2
    ALDH1L1["ALDH1L1"] -->|"inhibits"| SOX2
    DLK2["DLK2"] -->|"inhibits"| SOX2
    EGF["EGF"] -->|"inhibits"| SOX2
    GFAP["GFAP"] -->|"inhibits"| SOX2

Outgoing (341)

Target	Relation	Type	Str
Totipotency	regulates	process	0.95
Pluripotency	associated_with	process	0.95
Multipotency	associated_with	process	0.95
iPSC Reprogramming	involved_in	process	0.95
Tumor	therapeutic_target	disease	0.95
Cancer	inhibits	disease	0.95
Tumor	inhibits	disease	0.95
Neural Stem Cells	regulates	cell_type	0.92
Pluripotency	activates	phenotype	0.90
Pluripotency	involved_in	process	0.90
OCT4	interacts_with	gene	0.90
KLF4	interacts_with	gene	0.90
Cell Differentiation	regulates	process	0.90
Embryonic Stem Cells	expressed_in	cell_type	0.90
Pluripotency	promotes	process	0.90
NANOG	interacts_with	gene	0.90
DAX1	interacts_with	gene	0.90
Neurogenesis	involved_in	process	0.88
Notch Signaling	involved_in	pathway	0.85
Transcription	regulates	process	0.85
Cancer	therapeutic_target	disease	0.85
Cellular Senescence	associated_with	process	0.85
Alzheimer's Disease	biomarker_for	disease	0.80
Alzheimer'S Disease	involved_in	disease	0.80
Stem Cell	inhibits	pathway	0.80
Stem Cell Aging	regulates	process	0.75
Skin Fibroblasts	expressed_in	cell_type	0.75
Cancer	activates	disease	0.75
Als	inhibits	disease	0.75
Aging	expressed_in	disease	0.75
Als	therapeutic_target	disease	0.75
Alzheimer's Disease	involved_in	disease	0.75
MTOR	therapeutic_target	gene	0.70
ATG10	inhibits	gene	0.70
Astrocyte Heterogeneity	biomarker_for	phenotype	0.70
Epigenetic	expressed_in	pathway	0.70
CANCER	inhibits	gene	0.70
Wnt	regulates	pathway	0.70
Mtor	therapeutic_target	pathway	0.70
Metastasis	inhibits	pathway	0.70
Als	activates	disease	0.65
Als	expressed_in	disease	0.65
Cancer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Tumor	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65

Incoming (214)

Source	Relation	Type	Str
miRNAs	regulates	biomarker	0.80
OCT4	regulates	gene	0.80
CD44	inhibits	gene	0.70
KLF4	regulates	gene	0.70
AKT	therapeutic_target	gene	0.70
AGING	expressed_in	gene	0.70
CANCER	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
CANCER	inhibits	gene	0.70
Alzheimer's Disease	downregulates	disease	0.70
YAP	activates	protein	0.64
POU5F1	activates	gene	0.60
FGFR1	therapeutic_target	gene	0.60
KLF4	activates	gene	0.60
IL6	activates	gene	0.60
ALDH1L1	inhibits	gene	0.60
DLK2	inhibits	gene	0.60
EGF	inhibits	gene	0.60
GFAP	inhibits	gene	0.60
NESTIN	inhibits	gene	0.60
BRCA1	biomarker_for	gene	0.60
ATM	biomarker_for	gene	0.60
EZH2	biomarker_for	gene	0.60
GAIN	biomarker_for	gene	0.60
HES5	expressed_in	gene	0.60
CCT2	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
SNAP25	interacts_with	gene	0.60
ACTG1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PSMA3	interacts_with	gene	0.60
MYC	expressed_in	gene	0.60
OCT4	activates	gene	0.60
VIMENTIN	inhibits	gene	0.60
NESTIN	expressed_in	gene	0.60
OCT4	biomarker_for	gene	0.60
MYC	biomarker_for	gene	0.60
OCT4	interacts_with	gene	0.60
STAT3	activates	gene	0.60
SRC	activates	gene	0.60
ALDH1L1	expressed_in	gene	0.60
EGF	expressed_in	gene	0.60
NOTCH1	inhibits	gene	0.60
KLF4	biomarker_for	gene	0.60
DNMT3A	activates	gene	0.60
TP53	activates	gene	0.60
RB1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SOX2

Understanding Entity Pages

Summary

Wiki Pages (21)

SOX2

Cellular Reprogramming Therapies for Neurodegeneration

Neurogenesis

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

Longevity and Rejuvenation Therapies Landscape

Neurogenesis and Neurodegeneration

SETD1B

N-of-1 and Personalized Clinical Trial Design for CBS/PSP

Schwann Cells in Peripheral Neuropathy

Tanycytes

Adult Neurogenesis in Neurodegeneration

PPP5C — Protein Phosphatase 5 Catalytic Subunit

Hippocampal Neurogenesis in Neurodegeneration

epas1-protein

Dopaminergic Neurons (SNpc)

YAP/TAZ Signaling Pathway in Neurodegeneration

Oligodendrocyte Precursor Differentiation Failure in Neurodegeneration

LEF1

FZD8 Protein

Wnt Signaling Modulators for Neurodegeneration

stem-cell-therapy

Pathway Diagram

Outgoing (341)

Incoming (214)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)