concept

CNO

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

159Connections
1Hypotheses
1Analyses
50Outgoing
28Incoming

Summary

CNO is a concept in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 61 entities in the SciDEX knowledge graph.

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💡 Concept Info
NameCNO
Key Genes/ProteinsANXIETY
Related DiseasesAls, Anxiety, Addiction, Cancer, Aging
🔮 Predicted Structure: CNO — AlphaFold Q9NUP1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Microglia Activation Mechanism

mechanism · 3164 words

DREADDs in Neurodegeneration

mechanism · 2912 words

Microglia

cell · 2899 words

Microglia and neuroinflammation in Alzheimer's Disease

mechanism · 2789 words

Spinal Cord Lamina I Pain Neurons

cell · 2744 words

Pathway Diagram

graph TD
    CNO["CNO"]
    CNO -->|"target for"| Cancer["Cancer"]
    CNO -->|"target for"| Aging["Aging"]
    CNO -->|"target for"| Ms["Ms"]
    CNO -->|"target for"| Als["Als"]
    CNO -.biomarker for.-> Inflammation["Inflammation"]
    CNO -->|"target for"| Dementia["Dementia"]
    CNO -->|"target for"| Anxiety["Anxiety"]
    CNO -->|"target for"| Alzheimer["Alzheimer"]
    CNO -->|"regulates"| Schizophrenia["Schizophrenia"]
    h_e3506e5a["h-e3506e5a"] -->|"targets"| CNO
    PER["PER"] -->|"activates"| CNO
    CANCER["CANCER"] -->|"activates"| CNO
    INFLAMMATION["INFLAMMATION"] -.biomarker for.-> CNO
    GSR["GSR"] -->|"inhibits"| CNO
    ANXIETY["ANXIETY"] -->|"inhibits"| CNO
    DEMENTIA["DEMENTIA"] -->|"inhibits"| CNO
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"regulates"| CNO
    PARKINSON["PARKINSON"] -->|"regulates"| CNO
    AND["AND"] -->|"inhibits"| CNO

Outgoing (131)

TargetRelationTypeStr
Alsactivatesdisease0.75
Anxietyinhibitsdisease0.75
Addictionregulatesdisease0.65
Cancertherapeutic_targetdisease0.65
Agingtherapeutic_targetdisease0.65

Incoming (28)

SourceRelationTypeStr
h-e3506e5atargets_genehypothesis0.90
h-e3506e5atargetshypothesis0.80
ANXIETYinhibitsgene0.70
GSRinhibitsgene0.60
GSRtherapeutic_targetgene0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Synthetic Biology Rewiring via Orthogonal Receptors 0.420 neurodegeneration Microglia-astrocyte crosstalk amplificat

Mentioning Analyses (1)

Scientific analyses that reference this entity

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.521

Related Papers (12)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Current and future advances in practice: SAPHO syndrome and chronic non-bacteria [PMID:39411288] Furer V, Kishimoto M, Tomita T, Elkayam Rheumatol Adv Pract 2024 1
NMR-based isotopic and isotopomic analysis. [PMID:33198965] Akoka S, Remaud GS Prog Nucl Magn Reson Spectrosc 2020 1
Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid n [PMID:32632286] Nagai Y, Miyakawa N, Takuwa H, Hori Y, O Nat Neurosci 2020 1
Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progres [PMID:30814274] Runegaard AH, Fitzpatrick CM, Woldbye DP Pharmacol Rev 2019 1
The Utilization of Robotic Pets in Dementia Care. [PMID:27716673] Petersen S, Houston S, Qin H, Tague C, S J Alzheimers Dis 2017 1
Chemogenetic Modulation of Astrocytic Activity Rescues Hippocampus Associated Ne [PMID:41089460] ["Gerasimov E", "Berg M", "Bolshakova A" Neural plasticity 2025 0
Chemogenetic Tools and their Use in Studies of Neuropsychiatric Disorders. [PMID:38957949] Neřoldová M, Stuchlík A Physiological research 2024 0
Clozapine-N-oxide protects dopaminergic neurons against rotenone-induced neuroto [PMID:38182072] Sun Q, Wang Y, Hou L, Li S, Hong JS, Wan Free radical biology & medicin 2024 0
Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice. [PMID:36892930] ["Traut J", "Mengual J", "Meijer E", "Mc eLife 2023 0
To Be or No B2: A Rare Cause of Stridor and Weakness in a Toddler. [PMID:34395718] ["Frederick A", "Yang J", "Schneider S", Child neurology open 2021 0
Fragment Database FDB-17. [PMID:28375006] Visini R, Awale M, Reymond JL Journal of chemical informatio 2017 0
Clozapine metabolites protect dopaminergic neurons through inhibition of microgl [PMID:27184631] ["Jiang L", "Wu X", "Wang S", "Chen S", Journal of neuroinflammation 2016 0