concept

ELF3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ELF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

106Connections

0Hypotheses

0Analyses

50Outgoing

39Incoming

0Experiments

Summary

ELF3 is a concept in neurodegeneration research. Key relationships include: activates, expressed in, therapeutic target. Associated with ALS, Als, Cancer. Connected to 80 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ELF3
Key Genes/Proteins	PI3K, CANCER
Related Diseases	Gallbladder Cancer, Tumor, Cancer, Carcinoma, Als
Related Pathways	Metabolism Disruption, MAPK, Pi3K/Akt

Pathway Diagram

graph TD
    ELF3["ELF3"]
    ELF3 -->|"expressed in"| Carcinoma["Carcinoma"]
    ELF3 -->|"expressed in"| Als["Als"]
    ELF3 -->|"activates"| Tumor["Tumor"]
    ELF3 -->|"expressed in"| Ms["Ms"]
    ELF3 -->|"activates"| Cancer["Cancer"]
    ELF3 -->|"expressed in"| ALS["ALS"]
    ELF3 -->|"activates"| Akt["Akt"]
    PI3K["PI3K"] -->|"activates"| ELF3
    EGFR["EGFR"] -->|"expressed in"| ELF3
    GENES["GENES"] -->|"activates"| ELF3
    IL1B["IL1B"] -->|"activates"| ELF3
    BCL2L1["BCL2L1"] -->|"activates"| ELF3
    AKT["AKT"] -->|"activates"| ELF3
    ERK["ERK"] -->|"activates"| ELF3
    GAIN["GAIN"] -->|"activates"| ELF3
    PHGDH["PHGDH"] -->|"activates"| ELF3
    ACAT1["ACAT1"] -->|"activates"| ELF3

Outgoing (67)

Target	Relation	Type	Str
Gallbladder Cancer	risk_factor_for	disease	0.90
Metabolism Disruption	mediates	mechanism	0.80
Tumor	activates	disease	0.75
Cancer	activates	disease	0.75
Metabolism	regulates	process	0.75
PI3K	activates	gene	0.70
Pi3K/Akt	activates	pathway	0.70
CANCER	activates	gene	0.70
Carcinoma	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	expressed_in	disease	0.65
Als	activates	disease	0.65
Lung Cancer	activates	disease	0.65
GBC	associated_with	disease	0.64
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Glycolysis	expressed_in	pathway	0.60
Nf-Κb	activates	pathway	0.60
Mapk	activates	pathway	0.60
IL1B	activates	gene	0.60
Cell Cycle	associated_with	pathway	0.60
Glycolysis	associated_with	pathway	0.60
ERBB2	therapeutic_target	gene	0.60
ERBB3	therapeutic_target	gene	0.60
ERK	therapeutic_target	gene	0.60
Akt	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
Cell Cycle	expressed_in	pathway	0.60
TP53	causes	gene	0.60
ERBB3	activates	gene	0.60
AKT	activates	gene	0.60
ERK	activates	gene	0.60
GAIN	activates	gene	0.60
PHGDH	activates	gene	0.60
ACAT1	activates	gene	0.60
RAS	activates	gene	0.60
ERBB2	activates	gene	0.60
MEIS1	activates	gene	0.60
NF-ΚB	activates	gene	0.60
EGFR MUTATIONS	expressed_in	gene	0.60
Invasion	activates	pathway	0.60
Erk Signaling	activates	pathway	0.60

Incoming (39)

Source	Relation	Type	Str
MAPK	regulates	pathway	0.80
RAS	activates	gene	0.70
PI3K	activates	gene	0.60
EGFR	expressed_in	gene	0.60
GENES	activates	gene	0.60
IL1B	activates	gene	0.60
BCL2L1	activates	gene	0.60
AKT	activates	gene	0.60
ERK	activates	gene	0.60
GAIN	activates	gene	0.60
PHGDH	activates	gene	0.60
ACAT1	activates	gene	0.60
ERBB2	activates	gene	0.60
ERBB3	activates	gene	0.60
TP53	associated_with	gene	0.60
MEIS1	activates	gene	0.60
EGFR	associated_with	gene	0.60
EGFR MUTATIONS	associated_with	gene	0.60
ACAT1	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
CANCER	therapeutic_target	gene	0.60
CDH1	activates	gene	0.60
EGFR MUTATIONS	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
NF-ΚB	activates	gene	0.60
CYTOKINES	expressed_in	gene	0.60
CCND1	activates	gene	0.60
RNA	expressed_in	gene	0.60
AND	activates	gene	0.60
TP53	causes	gene	0.60
MAPK	activates	gene	0.60
AND	causes	gene	0.60
CANCER	activates	gene	0.60
TUMOR	activates	disease	0.50
Pi3K	activates	pathway	0.50
apoptosis	activates	process	0.50
NF-κB	activates	concept	0.50
CYTOKINES	activates	concept	0.50
Pi3K/Akt	activates	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found