Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CYP19A1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CYP19A1 |
| Key Genes/Proteins | TFEB, RNA, LC3B, UVRAG, AMBRA1, BECN1 |
| Related Diseases | sex differences, Cardiovascular, Cancer, Neurodegeneration, Parkinson |
Knowledge base pages for this entity
graph TD
CYP19A1["CYP19A1"]
CYP19A1 -->|"involved_in"| Estradiol["Estradiol"]
CYP19A1 -->|"regulates"| Sex_Differences_In_Autophagy["Sex Differences In Autophagy"]
CYP19A1 -->|"expressed in"| Inflammation["Inflammation"]
CYP19A1 -->|"expressed in"| STAR["STAR"]
CYP19A1 -->|"expressed in"| IL_6["IL-6"]
CYP19A1 -->|"expressed in"| Nf__b["Nf-Kappab"]
CYP19A1 -->|"expressed in"| AND["AND"]
CYP19A1 -->|"expressed in"| SIRT1["SIRT1"]
TFEB["TFEB"] -->|"binds_to"| CYP19A1
AMPK["AMPK"] -->|"expressed in"| CYP19A1
CYP17A1["CYP17A1"] -->|"expressed in"| CYP19A1
SIRT1 -->|"expressed in"| CYP19A1
IL_1["IL-1"] -->|"expressed in"| CYP19A1
STAR -->|"expressed in"| CYP19A1
INFLAMMATION["INFLAMMATION"] -->|"expressed in"| CYP19A1
INSULIN_RESISTANCE["INSULIN RESISTANCE"] -->|"expressed in"| CYP19A1| Target | Relation | Type | Str |
|---|---|---|---|
| sex differences | drives | phenotype | 0.75 |
| Cardiovascular | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Ischemia | associated_with | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| Inflammation | expressed_in | disease | 0.65 |
| autism spectrum disorder | associated_with | disease | 0.60 |
| RNA | associated_with | gene | 0.60 |
| LC3B | associated_with | gene | 0.60 |
| UVRAG | associated_with | gene | 0.60 |
| AMBRA1 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| FYCO1 | associated_with | gene | 0.60 |
| GABARAP | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| BCL2 | associated_with | gene | 0.60 |
| PSEN1 | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| VDAC2 | associated_with | gene | 0.60 |
| WDR45 | associated_with | gene | 0.60 |
| PIK3C3 | associated_with | gene | 0.60 |
| TFEB | associated_with | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| GABA | associated_with | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| SOX9 | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| ESR1 | associated_with | gene | 0.60 |
| RAB9A | associated_with | gene | 0.60 |
| Autophagy | associated_with | pathway | 0.60 |
| Amyloid | associated_with | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| PSEN2 | associated_with | gene | 0.60 |
| GLA | associated_with | gene | 0.60 |
| STAR | expressed_in | gene | 0.60 |
| IL-6 | expressed_in | gene | 0.60 |
| Nf-Κb | expressed_in | pathway | 0.60 |
| AND | expressed_in | gene | 0.60 |
| SIRT1 | expressed_in | gene | 0.60 |
| TNF-Α | expressed_in | gene | 0.60 |
| CYP17A1 | expressed_in | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| BCL2L1 | associated_with | gene | 0.60 |
| RAS | associated_with | gene | 0.60 |
| PRESENILIN | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TFEB | binds_to | protein | 0.90 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| BCL2L1 | associated_with | gene | 0.60 |
| LAMP2 | associated_with | gene | 0.60 |
| PSEN2 | associated_with | gene | 0.60 |
| PRESENILIN | associated_with | gene | 0.60 |
| HDAC6 | associated_with | gene | 0.60 |
| RAS | associated_with | gene | 0.60 |
| MAP1LC3B | associated_with | gene | 0.60 |
| AMYLOID | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| ATP6AP2 | associated_with | gene | 0.60 |
| ESR2 | associated_with | gene | 0.60 |
| GLA | associated_with | gene | 0.60 |
| RNA | associated_with | gene | 0.60 |
| GABA | associated_with | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| AMPK | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| FYCO1 | associated_with | gene | 0.60 |
| GABARAP | associated_with | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| TFEB | associated_with | gene | 0.60 |
| PIK3C3 | associated_with | gene | 0.60 |
| PSEN1 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| VDAC2 | associated_with | gene | 0.60 |
| UVRAG | associated_with | gene | 0.60 |
| WDR45 | associated_with | gene | 0.60 |
| SOX9 | associated_with | gene | 0.60 |
| CTSD | associated_with | gene | 0.60 |
| ESR1 | associated_with | gene | 0.60 |
| RAB9A | associated_with | gene | 0.60 |
| AMPK | expressed_in | gene | 0.60 |
| CYP17A1 | expressed_in | gene | 0.60 |
| SIRT1 | expressed_in | gene | 0.60 |
| IL-1 | expressed_in | gene | 0.60 |
| STAR | expressed_in | gene | 0.60 |
| INFLAMMATION | expressed_in | gene | 0.60 |
| INSULIN RESISTANCE | expressed_in | gene | 0.60 |
| TNF | expressed_in | gene | 0.60 |
| NF-ΚB | expressed_in | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| AMBRA1 | associated_with | gene | 0.60 |
| BCL2 | associated_with | gene | 0.60 |
| LC3B | associated_with | gene | 0.60 |
| IL-6 | expressed_in | gene | 0.60 |
| TNF-Α | expressed_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||