concept

MALAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MALAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

1Hypotheses

1Analyses

50Outgoing

30Incoming

0Experiments

1Debates

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💡 Concept Info

Name	MALAT1
Key Genes/Proteins	AKT, AND, APOPTOSIS, App, ASTROCYTES
Related Diseases	Als, ALS, Autism
Related Pathways	Akt, Apoptosis, apoptosis pathway
Linked Hypotheses	1 hypotheses

Pathway Diagram

graph TD
    MALAT1["MALAT1"]
    style MALAT1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    MALAT1 -->|"expressed in"| Neurons["/Neurons/"]
    MALAT1 -->|"expressed in"| Astrocytes["/Astrocytes/"]
    MALAT1 -->|"expressed in"| Neuron["/Neuron/"]
    MALAT1 -->|"expressed in"| Astrocyte["/Astrocyte/"]
    MALAT1 -->|"expressed in"| Microglia["/Microglia/"]
    MALAT1 -->|"interacts"| Cancer["Cancer"]
    MALAT1 -->|"target for"| Als["Als"]
    MALAT1 -.->|"inhibits"| Tumor["Tumor"]
    MALAT1 -->|"target for"| Ms["Ms"]
    Oligonucleotide_Transport_Vehi{"Oligonucleotide Transport Vehicle"} -.->|"downregulates"| MALAT1
    MICRORNAS([MICRORNAS]) -->|"interacts"| MALAT1
    AND([AND]) -->|"interacts"| MALAT1
    DNMT1([DNMT1]) -->|"activates"| MALAT1
    BAX([BAX]) -->|"expressed in"| MALAT1
    DNMT3B([DNMT3B]) -->|"activates"| MALAT1
    APOPTOSIS([APOPTOSIS]) -->|"activates"| MALAT1
    ASTROCYTES([ASTROCYTES]) -->|"target for"| MALAT1

Outgoing (71)

Target	Relation	Type	Str
h-01eb4f1d71	targeted_by	hypothesis	1.00
Astrocytes	expressed_in	cell_type	0.85
Neurons	expressed_in	cell_type	0.85
Neurological Disorders	associated_with	disease	0.85
Astrocyte	expressed_in	cell_type	0.80
colorectal cancer	promotes	disease	0.80
Neuron	expressed_in	cell_type	0.80
Microglia	expressed_in	cell_type	0.80
Cell Survival	promotes	process	0.80
Endothelial Cells	expressed_in	cell_type	0.80
Colorectal Cancer	implicated_in	disease	0.75
splicing regulation	modulates	process	0.70
ALS	transports	disease	0.65
Autism	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
MICROGLIA	therapeutic_target	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Transferrin	therapeutic_target	protein	0.60
NEAT1	expressed_in	gene	0.60
apoptosis pathway	participates_in	pathway	0.60
MMP2	activates	gene	0.60
MMP9	activates	gene	0.60
NEAT1	activates	gene	0.60
VEGFA	activates	gene	0.60
MIRNAS	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Epigenetic	regulates	pathway	0.60
Autophagy	associated_with	pathway	0.60
senescence	participates_in	pathway	0.60
Astrocyte	therapeutic_target	cell_type	0.60
Oligodendrocyte	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
Endothelial	therapeutic_target	cell_type	0.60
Microglia	therapeutic_target	cell_type	0.60
App	therapeutic_target	protein	0.60
RNA	targets	gene	0.60
RNA	associated_with	gene	0.60
NORAD	interacts_with	gene	0.60
RELA	interacts_with	gene	0.60
STAT3	interacts_with	gene	0.60
TP53	interacts_with	gene	0.60

Incoming (30)

Source	Relation	Type	Str
h-01eb4f1d71	targets	hypothesis	1.00
Antisense Oligonucleotides	downregulates	drug	0.95
Oligonucleotide Transport Vehicle	downregulates	drug	0.92
antisense oligonucleotides	therapeutic_target	drug	0.90
TDP-43	binds	protein	0.90
Oligonucleotide Transport Vehicle	targets	drug	0.90
Transferrin Receptor Antibody	downregulates	drug	0.75
HIF1A	activates	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
TFR1	therapeutic_target	gene	0.60
GAS5	expressed_in	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
GAS5	activates	gene	0.60
MICRORNAS	interacts_with	gene	0.60
DNMT1	activates	gene	0.60
BAX	expressed_in	gene	0.60
DNMT3B	activates	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
RNA	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
JUN	interacts_with	gene	0.60
AND	activates	gene	0.60
Astrocytes	associated_with	cell_type	0.50
microglia	associated_with	cell_type	0.50
OLIGODENDROCYTES	associated_with	concept	0.50
Cardiac	associated_with	disease	0.50
ENDOTHELIAL	associated_with	concept	0.50
NEURONS	associated_with	concept	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MALAT1 Three-Way Junction as a Druggable Target for Structur	0.591	molecular-biology	What are the conserved secondary structu

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the conserved secondary structures in dilncRNAs that enable selective t

molecular biology | 2026-04-10 | 5 hypotheses Top: 0.657

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The ASO therapeutic hypothesis assumes dilncRNAs have targetable conserved struc

closed · Rounds: 4 · Score: 0.69 · 2026-04-21

Related Research

Hypotheses and analyses mentioning MALAT1 in their description or question text

No additional research found