concept

MALAT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MALAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

102Connections

0Hypotheses

0Analyses

50Outgoing

32Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MALAT1
Key Genes/Proteins	TDP-43
Related Diseases	Neurological Disorders, colorectal cancer, Colorectal Cancer

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MALAT1["MALAT1"]
    style MALAT1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    MALAT1 -->|"expressed in"| Neurons["/Neurons/"]
    MALAT1 -->|"expressed in"| Astrocytes["/Astrocytes/"]
    MALAT1 -->|"expressed in"| Neuron["/Neuron/"]
    MALAT1 -->|"expressed in"| Astrocyte["/Astrocyte/"]
    MALAT1 -->|"expressed in"| Microglia["/Microglia/"]
    MALAT1 -->|"interacts"| Cancer["Cancer"]
    MALAT1 -->|"target for"| Als["Als"]
    MALAT1 -.->|"inhibits"| Tumor["Tumor"]
    MALAT1 -->|"target for"| Ms["Ms"]
    Oligonucleotide_Transport_Vehi{"Oligonucleotide Transport Vehicle"} -.->|"downregulates"| MALAT1
    MICRORNAS([MICRORNAS]) -->|"interacts"| MALAT1
    AND([AND]) -->|"interacts"| MALAT1
    DNMT1([DNMT1]) -->|"activates"| MALAT1
    BAX([BAX]) -->|"expressed in"| MALAT1
    DNMT3B([DNMT3B]) -->|"activates"| MALAT1
    APOPTOSIS([APOPTOSIS]) -->|"activates"| MALAT1
    ASTROCYTES([ASTROCYTES]) -->|"target for"| MALAT1

Outgoing (70)

Target	Relation	Type	Str
Neurons	expressed_in	cell_type	0.85
Astrocytes	expressed_in	cell_type	0.85
Neurological Disorders	associated_with	disease	0.85
Neuron	expressed_in	cell_type	0.80
Astrocyte	expressed_in	cell_type	0.80
Microglia	expressed_in	cell_type	0.80
Endothelial Cells	expressed_in	cell_type	0.80
colorectal cancer	promotes	disease	0.80
Cell Survival	promotes	process	0.80
Colorectal Cancer	implicated_in	disease	0.75
Cancer	interacts_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Tumor	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
ALS	transports	disease	0.65
MIRNAS	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
Epigenetic	regulates	pathway	0.60
Autophagy	associated_with	pathway	0.60
CANCER	activates	gene	0.60
AKT	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
Akt	activates	pathway	0.60
Autophagy	activates	pathway	0.60
CASP3	expressed_in	gene	0.60
BCL-2	expressed_in	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
DNMT3A	activates	gene	0.60
DNA	activates	gene	0.60
Apoptosis	activates	pathway	0.60
Dna Methylation	associated_with	pathway	0.60
MICROGLIA	therapeutic_target	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
RNA	causes	gene	0.60
AND	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
TFR1	transports	gene	0.60
MICROGLIA	causes	gene	0.60
Blood-Brain Barrier	transports	pathway	0.60
Astrocyte	therapeutic_target	cell_type	0.60
Oligodendrocyte	therapeutic_target	cell_type	0.60
Neuron	therapeutic_target	cell_type	0.60
Endothelial	therapeutic_target	cell_type	0.60

Incoming (32)

Source	Relation	Type	Str
Antisense Oligonucleotides	downregulates	drug	0.95
Oligonucleotide Transport Vehicle	downregulates	drug	0.92
Oligonucleotide Transport Vehicle	targets	drug	0.90
TDP-43	binds	protein	0.90
antisense oligonucleotides	therapeutic_target	drug	0.90
Transferrin Receptor Antibody	downregulates	drug	0.75
MICRORNAS	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
AND	activates	gene	0.60
DNMT1	activates	gene	0.60
BAX	expressed_in	gene	0.60
DNMT3B	activates	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
AND	expressed_in	gene	0.60
APOPTOSIS	activates	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
TFR1	therapeutic_target	gene	0.60
AND	therapeutic_target	gene	0.60
RNA	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
GAS5	expressed_in	gene	0.60
BAX	activates	gene	0.60
BCL2	activates	gene	0.60
GAS5	activates	gene	0.60
HIF1A	activates	gene	0.60
JUN	interacts_with	gene	0.60
microglia	associated_with	cell_type	0.50
Astrocytes	associated_with	cell_type	0.50
NEURONS	associated_with	concept	0.50
ENDOTHELIAL	associated_with	concept	0.50
OLIGODENDROCYTES	associated_with	concept	0.50
Cardiac	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MALAT1

Understanding Entity Pages

Wiki Pages (20)

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Epigenetic Alterations in Alzheimer's Disease

RNA Metabolism Dysregulation in Alzheimer's Disease

Transcriptional Regulation in Neurodegeneration

Neuroinflammation in Parkinson's Disease

TBX2 — T-Box Transcription Factor 2

epigenetics-neurodegeneration

ftd-tdp43-pathway

Epigenetic Changes in PSP

PD-1/PD-L1 Immune Checkpoint Signaling in Neurodegeneration

Chromatin Remodeling in Neurodegeneration

Exosome Biogenesis in Neurodegeneration

TAR DNA-Binding Protein 43 (TDP-43)

Tauopathy

Non-coding RNAs in Neurodegeneration

Spliceosome and Neurodegeneration