disease

Crohn Disease

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Crohn Disease: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

149Connections

0Hypotheses

0Analyses

38Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	AUTOPHAGY, ATG, INFLAMMATION, AMYOTROPHIC LATERAL SCLEROSIS, NEURODEGENERATIVE DISEASES, CANCER, OPTN, DEMENTIA
KG Connections	149 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Crohn_Disease["Crohn Disease"] -->|"activates"| Inflammation["Inflammation"]
    Crohn_Disease["Crohn Disease"] -->|"therapeutic target"| Microbiota["Microbiota"]
    Crohn_Disease["Crohn Disease"] -->|"regulates"| Immune_Response["Immune Response"]
    Crohn_Disease["Crohn Disease"] -->|"implicated in"| Autophagy["Autophagy"]
    Crohn_Disease["Crohn Disease"] -->|"regulates"| Als["Als"]
    Crohn_Disease["Crohn Disease"] -->|"activates"| Inflammatory_Bowel_Disease["Inflammatory Bowel Disease"]
    INFLAMMATION["INFLAMMATION"] -->|"activates"| Crohn_Disease["Crohn Disease"]
    Autophagy_1["Autophagy"] -->|"associated"| Crohn_Disease["Crohn Disease"]
    INFLAMMATION_2["INFLAMMATION"] -->|"regulates"| Crohn_Disease["Crohn Disease"]
    CYTOKINES["CYTOKINES"] -->|"regulates"| Crohn_Disease["Crohn Disease"]
    style Crohn_Disease fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (38)

Target	Relation	Type	Str
Inflammation	activates	disease	0.75
Microbiota	therapeutic_target	pathway	0.70
Immune Response	regulates	pathway	0.70
Autophagy	implicated_in	pathway	0.70
Als	regulates	disease	0.65
Inflammatory Bowel Disease	activates	disease	0.65
Oxidative Stress	therapeutic_target	pathway	0.60
Autophagy	regulates	pathway	0.60
Adaptive Immunity	regulates	pathway	0.60
Complement	regulates	pathway	0.60
Wnt	activates	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
Autophagy	activates	pathway	0.60
Immunotherapy	implicated_in	pathway	0.60
Immune Response	implicated_in	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
Complement	biomarker_for	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Nf-Κb	therapeutic_target	pathway	0.60
Infection	regulates	disease	0.55
Inflammation	regulates	disease	0.55
Parkinson	activates	disease	0.55
Ulcerative Colitis	activates	disease	0.55
Infection	implicated_in	disease	0.55
Asthma	implicated_in	disease	0.55
Inflammation	implicated_in	disease	0.55
Glaucoma	implicated_in	disease	0.55
Amyotrophic Lateral Sclerosis	implicated_in	disease	0.55
Dementia	implicated_in	disease	0.55
Huntington	therapeutic_target	disease	0.55
Glaucoma	therapeutic_target	disease	0.55
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.55
Fibrosis	biomarker_for	disease	0.55
Inflammatory Bowel Disease	biomarker_for	disease	0.55
Ulcerative Colitis	regulates	disease	0.55
Inflammatory Bowel Disease	regulates	disease	0.55
Cystic Fibrosis	activates	disease	0.50

Incoming (111)

Source	Relation	Type	Str
INFLAMMATION	activates	gene	0.95
Autophagy	associated_with	process	0.75
INFLAMMATION	regulates	gene	0.75
CYTOKINES	regulates	gene	0.75
P53	activates	gene	0.75
AUTOPHAGY	implicated_in	gene	0.75
INFLAMMATION	implicated_in	gene	0.75
Autophagy	contributes_to	process	0.75
NATURAL COMPOUNDS	therapeutic_target	gene	0.65
OXIDATIVE STRESS	therapeutic_target	gene	0.65
CANCER	therapeutic_target	gene	0.65
GENES	therapeutic_target	gene	0.65
NRF2	therapeutic_target	gene	0.65
Inflammatory Bowel Disease	therapeutic_target	disease	0.65
AUTOPHAGY	regulates	gene	0.65
NDP52	regulates	gene	0.65
SQSTM1	regulates	gene	0.65
P62	regulates	gene	0.65
NIX	regulates	gene	0.65
GENES	regulates	gene	0.65
UBIQUITIN	regulates	gene	0.65
MITOCHONDRIA	regulates	gene	0.65
BNIP3L	regulates	gene	0.65
PARKIN	regulates	gene	0.65
LRRK2	activates	gene	0.65
PARKINSON	activates	gene	0.65
PARKINSON'S DISEASE	activates	gene	0.65
CD4	regulates	gene	0.65
FOXP3	regulates	gene	0.65
ROS	activates	gene	0.65
RAS	activates	gene	0.65
APC	activates	gene	0.65
CANCER	activates	gene	0.65
PRO-INFLAMMATORY GENES	activates	gene	0.65
GENES	activates	gene	0.65
ATG	implicated_in	gene	0.65
AUTOPHAGY	activates	gene	0.65
OPTN	activates	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	implicated_in	gene	0.65
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.65
CANCER	implicated_in	gene	0.65
OPTN	implicated_in	gene	0.65
DEMENTIA	implicated_in	gene	0.65
HUNTINGTON	therapeutic_target	gene	0.65
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.65
HUNTINGTON'S DISEASE	therapeutic_target	gene	0.65
AUTOPHAGY	therapeutic_target	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	therapeutic_target	gene	0.65
MIRNAS	biomarker_for	gene	0.65
OXIDATIVE STRESS	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Crohn Disease

Understanding Entity Pages

Wiki Pages (5)

LRRK2 Inhibitor Therapy

STING-CASM-GABARAP-LRRK2 Pathway in Parkinson's Disease

ATG16L2 Gene