protein

PYCARD/ASC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PYCARD/ASC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

78Connections

0Hypotheses

0Analyses

43Outgoing

35Incoming

Summary

Page for PYCARD/ASC Protein

View on Wiki →

🔬 Protein Info

Gene Symbol	PYCARD/ASC
Molecular Weight	22 kDa
Pathways	Nlrp3 Inflammasome, Unfolded Protein Response, Microrna
Interactions	UBIQUITIN, ATG7, IBA1, NLRP3, LC3B, PARKINSON
KG Connections	78 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PYCARD_ASC["<b>PYCARD/ASC</b>"]
    UBIQUITIN["UBIQUITIN"]
    PYCARD_ASC -->|"interacts with"| UBIQUITIN
    ATG7["ATG7"]
    PYCARD_ASC -->|"interacts with"| ATG7
    IBA1["IBA1"]
    PYCARD_ASC -->|"interacts with"| IBA1
    NLRP3["NLRP3"]
    PYCARD_ASC -->|"interacts with"| NLRP3
    LC3B["LC3B"]
    PYCARD_ASC -->|"interacts with"| LC3B
    TUMOR["TUMOR"]
    PYCARD_ASC -->|"interacts with"| TUMOR
    PARKINSON["PARKINSON"]
    PYCARD_ASC -->|"interacts with"| PARKINSON
    Neurodegenerative_Diseases["Neurodegenerative Diseases"]
    PYCARD_ASC -->|"interacts with"| Neurodegenerative_Diseases
    disease["disease"]
    PYCARD_ASC -->|"interacts with"| disease
    NEURONS["NEURONS"]
    PYCARD_ASC -->|"interacts with"| NEURONS
    Substantia_Nigra["Substantia Nigra"]
    PYCARD_ASC -->|"interacts with"| Substantia_Nigra
    DOPAMINERGIC["DOPAMINERGIC"]
    PYCARD_ASC -->|"interacts with"| DOPAMINERGIC
    SYNUCLEIN["SYNUCLEIN"]
    PYCARD_ASC -->|"interacts with"| SYNUCLEIN
    DOPAMINERGIC_NEURONS["DOPAMINERGIC NEURONS"]
    PYCARD_ASC -->|"interacts with"| DOPAMINERGIC_NEURONS
    RAPAMYCIN["RAPAMYCIN"]
    PYCARD_ASC -->|"interacts with"| RAPAMYCIN
    CENTRAL_NERVOUS_SYSTEM["CENTRAL NERVOUS SYSTEM"]
    PYCARD_ASC -->|"interacts with"| CENTRAL_NERVOUS_SYSTEM
    LAMP1["LAMP1"]
    PYCARD_ASC -->|"interacts with"| LAMP1
    MARCH7["MARCH7"]
    PYCARD_ASC -->|"interacts with"| MARCH7
    NFKB["NFKB"]
    PYCARD_ASC -->|"interacts with"| NFKB
    MACROPHAGES["MACROPHAGES"]
    PYCARD_ASC -->|"interacts with"| MACROPHAGES
    Melanoma["Melanoma"]
    PYCARD_ASC -->|"interacts with"| Melanoma
    IL_1["IL-1"]
    PYCARD_ASC -->|"interacts with"| IL_1
    UBIQUITIN["UBIQUITIN"]
    PYCARD_ASC -->|"activates"| UBIQUITIN
    NLRP3["NLRP3"]
    PYCARD_ASC -->|"activates"| NLRP3
    TUMOR["TUMOR"]
    PYCARD_ASC -->|"activates"| TUMOR
    INFLAMMASOME["INFLAMMASOME"]
    PYCARD_ASC -->|"activates"| INFLAMMASOME
    Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    PYCARD_ASC -->|"activates"| Nlrp3_Inflammasome
    IL_1["IL-1"]
    PYCARD_ASC -->|"activates"| IL_1
    BRG1["BRG1"]
    PYCARD_ASC -->|"activates"| BRG1
    BECLIN1["BECLIN1"]
    PYCARD_ASC -->|"activates"| BECLIN1

Outgoing (43)

Target	Relation	Type	Str
UBIQUITIN	interacts_with	protein	0.50
ATG7	interacts_with	protein	0.50
IBA1	interacts_with	protein	0.50
NLRP3	interacts_with	protein	0.50
LC3B	interacts_with	protein	0.50
TUMOR	interacts_with	disease	0.50
PARKINSON	interacts_with	gene	0.50
Neurodegenerative Diseases	interacts_with	disease	0.50
disease	interacts_with	disease	0.50
NEURONS	interacts_with	concept	0.50
Substantia Nigra	interacts_with	entity	0.50
DOPAMINERGIC	interacts_with	concept	0.50
SYNUCLEIN	interacts_with	concept	0.50
DOPAMINERGIC NEURONS	interacts_with	concept	0.50
RAPAMYCIN	interacts_with	concept	0.50
CENTRAL NERVOUS SYSTEM	interacts_with	concept	0.50
LAMP1	interacts_with	protein	0.50
MARCH7	interacts_with	protein	0.50
NFKB	interacts_with	concept	0.50
MACROPHAGES	interacts_with	concept	0.50
Melanoma	interacts_with	disease	0.50
IL-1	interacts_with	concept	0.50
UBIQUITIN	activates	protein	0.50
NLRP3	activates	protein	0.50
TUMOR	activates	disease	0.50
Nlrp3 Inflammasome	activates	pathway	0.50
IL-1	activates	concept	0.50
BRG1	activates	protein	0.50
BECLIN1	activates	gene	0.50
cancer	activates	disease	0.50
MAPK	activates	gene	0.50
MAP1LC3	activates	gene	0.50
Unfolded Protein Response	activates	pathway	0.50
Stem Cell	activates	cell_type	0.50
disease	activates	disease	0.50
Dendritic Cell	activates	cell_type	0.50
COLORECTAL CANCER	activates	disease	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
Reactive Oxygen Species	activates	process	0.50
RAPAMYCIN	activates	concept	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50

Incoming (35)

Source	Relation	Type	Str
ACTB	interacts_with	gene	0.50
AIF1	interacts_with	gene	0.50
Autophagy	interacts_with	process	0.50
SNCA	interacts_with	gene	0.50
IL1B	interacts_with	gene	0.50
GFAP	interacts_with	gene	0.50
BECN1	interacts_with	gene	0.50
SQSTM1	interacts_with	gene	0.50
PYCARD	interacts_with	gene	0.50
MAP1LC3B	interacts_with	gene	0.50
CASP1	interacts_with	gene	0.50
GAPDH	interacts_with	gene	0.50
ATG5	interacts_with	gene	0.50
AIM2	interacts_with	gene	0.50
NLRC4	interacts_with	gene	0.50
Autophagy	activates	process	0.50
IL1B	activates	gene	0.50
IL18	activates	gene	0.50
PYCARD	activates	gene	0.50
CASP1	activates	gene	0.50
NLRC4	activates	gene	0.50
ATG5	activates	gene	0.50
Pi3K	activates	pathway	0.50
ULK1	activates	gene	0.50
TNFA	activates	gene	0.50
RIPK3	activates	gene	0.50
STAT3	activates	gene	0.50
BECN1	activates	gene	0.50
ERN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
mTOR	activates	entity	0.50
MELK	activates	gene	0.50
NOD2	activates	gene	0.50
RIPK2	activates	gene	0.50
SMARCA4	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PYCARD/ASC

Understanding Entity Pages

Summary

Wiki Pages (7)

ASC (PYCARD)

nlrp3-inflammasome

aim2-inflammasome-modulator-therapy

PYCARD Gene

NEK7 Gene