concept

P53 PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P53 PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

0Hypotheses

1Analyses

11Outgoing

50Incoming

0Experiments

2Debates

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💡 Concept Info

Name	P53 PATHWAY
Key Genes/Proteins	AMPK, MYC, SIRT1, TP53
Related Diseases	ALZHEIMER'S DISEASE, APOPTOSIS, OXIDATIVE STRESS

Pathway Diagram

graph TD
    P53_PATHWAY["P53 PATHWAY"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| P53_PATHWAY
    AND["AND"] -->|"activates"| P53_PATHWAY
    APP_PS1["APP/PS1"] -->|"activates"| P53_PATHWAY
    APP["APP"] -->|"activates"| P53_PATHWAY
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| P53_PATHWAY
    AGING["AGING"] -->|"activates"| P53_PATHWAY
    ALZHEIMER["ALZHEIMER"] -->|"activates"| P53_PATHWAY
    ROS["ROS"] -->|"activates"| P53_PATHWAY
    DEMENTIA["DEMENTIA"] -->|"activates"| P53_PATHWAY
    P53["P53"] -->|"activates"| P53_PATHWAY

Outgoing (11)

Target	Relation	Type	Str
neural stem cells	active_in	cell_type	0.60
unfolded protein response	crosstalk_with	pathway	0.60
endothelial cells	active_in	cell_type	0.60
Proteins	associated_with	protein	0.50
AMPK	associated_with	gene	0.50
MYC	associated_with	gene	0.50
RIBOSOME	associated_with	organelle	0.45
APOPTOSIS	associated_with	phenotype	0.45
NEURONS	associated_with	cell_type	0.45
NEURON	associated_with	cell_type	0.45
TP53	associated_with	gene	0.45

Incoming (79)

Source	Relation	Type	Str
AKT	participates_in	gene	0.70
CDKN1A	regulates	gene	0.70
SIRT1	inhibits	gene	0.65
APP	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AGING	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ROS	activates	gene	0.60
DEMENTIA	activates	gene	0.60
P53	activates	gene	0.60
GENES	therapeutic_target	gene	0.60
APP/PS1	activates	gene	0.60
TNF-Α	therapeutic_target	gene	0.60
MYELIN	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
apoptosis pathway	crosstalk_with	pathway	0.60
AMPK	participates_in	gene	0.60
AND	activates	gene	0.60
TP53	inhibits	gene	0.60
AKT1	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
RAGE	therapeutic_target	gene	0.60
AKT	inhibits	gene	0.60
AND	inhibits	gene	0.60
CD14	activates	gene	0.60
TNF	expressed_in	gene	0.60
TREM2	expressed_in	gene	0.60
ICAM1	activates	gene	0.60
GENES	expressed_in	gene	0.60
ITGAM	activates	gene	0.60
JUN	activates	gene	0.60
NF-ΚB	expressed_in	gene	0.60
TLR2	activates	gene	0.60
CXCL2	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
MSR1	expressed_in	gene	0.60
NFKBIA	activates	gene	0.60
CANCER	activates	gene	0.60
TNF-Α	expressed_in	gene	0.60
MRC1	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
IL1B	expressed_in	gene	0.60
aging	involves	disease	0.60
APOPTOSIS	inhibits	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
C9ORF72	activates	gene	0.60
STAU1	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	protects_against	gene	0.60
DNA	protects_against	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 15 hypotheses Top: 0.822

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning P53 PATHWAY in their description or question text

No additional research found