WIPI1

Understanding Entity Pages

This page aggregates everything SciDEX knows about WIPI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

WIPI1 (WD Repeat Domain, Pyrin Interacting 1) is a PROPPIN family protein involved in autophagy, particularly in the formation of omegasomes and autophagosomes. It plays critical roles in cellular homeostasis and is implicated in neurodegenerative dise...

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flowchart TD
    WIPI1["WIPI1"] -->|"interacts with"| Als["Als"]
    WIPI1["WIPI1"] -->|"activates"| Als["Als"]
    WIPI1["WIPI1"] -->|"associated with"| Als["Als"]
    WIPI1["WIPI1"] -->|"associated with"| Ms["Ms"]
    WIPI1["WIPI1"] -->|"associated with"| Diabetes["Diabetes"]
    WIPI1["WIPI1"] -->|"interacts with"| ALS["ALS"]
    NDP52["NDP52"] -->|"recruits"| WIPI1["WIPI1"]
    WIPI1["WIPI1"] -->|"interacts with"| Mitophagy["Mitophagy"]
    WIPI1["WIPI1"] -->|"interacts with"| Autophagy["Autophagy"]
    WIPI1["WIPI1"] -->|"interacts with"| PARKIN["PARKIN"]
    WIPI1["WIPI1"] -->|"interacts with"| NDP52["NDP52"]
    WIPI1["WIPI1"] -->|"interacts with"| LC3["LC3"]
    style WIPI1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Diabetes fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style NDP52 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Mitophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#333,color:#e0e0e0
    style PARKIN fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style LC3 fill:#4a1a6b,stroke:#333,color:#e0e0e0