protein

presenilin-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about presenilin-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

161Connections

0Hypotheses

0Analyses

22Outgoing

38Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	PRESENILIN-1
Chromosome	14q24.2.
Protein Family	Presenilin family (intramembrane aspartyl protease)
Molecular Weight	52 kDa
Amino Acids	467 aa
Pathways	Amyloid, Alpha-Synuclein, Oxidative Stress, Notch, Apoptosis
GeneCards	PRESENILIN-1
Human Protein Atlas	PRESENILIN-1
Associated Diseases	Alzheimer'S Disease, disease
KG Connections	22 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    presenilin_1["<b>presenilin-1</b>"]
    MITOCHONDRIA["MITOCHONDRIA"]
    presenilin_1 -->|"regulates"| MITOCHONDRIA
    PRESENILIN(["PRESENILIN"])
    presenilin_1 -->|"regulates"| PRESENILIN
    BCL_2(["BCL-2"])
    presenilin_1 -->|"regulates"| BCL_2
    disease{"disease"}
    presenilin_1 -->|"regulates"| disease
    GLUTAMATE["GLUTAMATE"]
    presenilin_1 -->|"regulates"| GLUTAMATE
    Proteins(["Proteins"])
    presenilin_1 -->|"regulates"| Proteins
    style presenilin_1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7

Outgoing (123)

Target	Relation	Type	Str
presenilin-2	causes	protein	0.50
EGFR	regulates	gene	0.50
PSEN1	causes	gene	0.50
PSEN2	causes	gene	0.50
MITOCHONDRIA	regulates	cell_type	0.50
PRESENILIN	regulates	protein	0.50
BCL-2	regulates	protein	0.50
disease	regulates	disease	0.50
GLUTAMATE	regulates	concept	0.50
Proteins	regulates	protein	0.50
ENDOPLASMIC RETICULUM	regulates	concept	0.50
PRESENILIN	causes	protein	0.50
ALZHEIMER	causes	gene	0.50
Alzheimer'S Disease	causes	disease	0.50
disease	causes	disease	0.50
ALZHEIMER'S	causes	concept	0.50
PRESENILIN	associated_with	protein	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
AMYLOID	causes	gene	0.50

Incoming (38)

Source	Relation	Type	Str
HUNTINGTIN	regulates	gene	0.60
PSEN2	causes	gene	0.60
APP	causes	gene	0.60
PRESENILIN-2	causes	gene	0.60
EGFR	regulates	gene	0.60
PSEN1	activates	gene	0.60
GAIN	causes	gene	0.60
PSEN1	causes	gene	0.60
TAU	regulates	gene	0.60
NOTCH1	activates	gene	0.60
APP	interacts_with	gene	0.60
BCL-2	associated_with	gene	0.60
AMYLOID	regulates	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
STROKE	regulates	gene	0.60
MITOCHONDRIA	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
PRESENILIN	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
AGING	regulates	gene	0.60
EXERCISE	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
GENES	causes	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	causes	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
AGING	causes	gene	0.60
NEURODEGENERATION	causes	gene	0.60
WNT	regulates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
NOTCH	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AMYLOID-BETA	regulates	gene	0.60
AMYLOID	causes	gene	0.60
benchmark_ot_ad_answer_key:PRESENILIN-1	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

presenilin-1

Understanding Entity Pages

Wiki Pages (20)

calcium-dysregulation-comparison

Alzheimer's Disease Mechanism Index

DIAN-TU-001 Trial (NCT01760005)

omega-3-fatty-acids-neurodegeneration

Amyloid Cascade Pathway

PEN2 Gene

APP Flemish Mutation (APP Flemish)

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

Amyloid-Beta Aggregation and Plaque Formation

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD

genetics

Lysosomal Dysfunction in Neurodegeneration

autophagy-lysosomal-alzheimers

Amyloid Precursor Protein (APP)

Calcium Signaling Dysregulation in Alzheimer's Disease

PSEN2 — Presenilin 2

Gamma-Secretase Complex (γ-Secretase)

epigenetics-neurodegeneration