Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NEUROINFLAMMATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NEUROINFLAMMATION is a phenotype associated with neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with AD, ALS, ALZHEIMER. Connected to 2614 entities in the SciDEX knowledge graph.
Knowledge base pages for this entity
graph TD
subgraph Signaling["Signaling"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| NEURODEGENERATION["NEURODEGENERATION"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| Als["Als"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| Neuroinflammation_1["Neuroinflammation"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| Inflammation_2["Inflammation"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"activates"| Autophagy["Autophagy"]
CYTOKINES["CYTOKINES"] -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"activates"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
end
subgraph Pathology["Pathology"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"associated with"| NEURON["NEURON"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"associated with"| TAU["TAU"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"associated with"| Neuroinflammation["Neuroinflammation"]
NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"associated with"| Inflammation["Inflammation"]
APOE["APOE"] -->|"associated with"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
MICROGLIA["MICROGLIA"] -->|"associated with"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
APP["APP"] -->|"associated with"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
MITOCHONDRIA["MITOCHONDRIA"] -->|"associated with"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
end
style NEUROINFLAMMATION fill:#5d4400,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style NEURODEGENERATION fill:#5d4400,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURON fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style TAU fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neuroinflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Neuroinflammation_1 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation_2 fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APOE fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MICROGLIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style APP fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOCHONDRIA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style CYTOKINES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style MITOCHONDRIAL_DYSFUNCTION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| NEURON | associated_with | gene | 1.00 |
| TAU | associated_with | gene | 1.00 |
| Neuroinflammation | associated_with | disease | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| Parkinson | activates | disease | 1.00 |
| Toll-Like Receptor | activates | pathway | 1.00 |
| Aging | activates | disease | 1.00 |
| Inflammasome | activates | pathway | 1.00 |
| Dementia | activates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Alzheimer | therapeutic_target | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Neuroinflammation | therapeutic_target | disease | 1.00 |
| Phagocytosis | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Stroke | regulates | disease | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Immune Response | therapeutic_target | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Inflammation | interacts_with | disease | 1.00 |
| Neuroinflammation | interacts_with | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Neuroinflammation | inhibits | disease | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Parkinson | regulates | disease | 1.00 |
| Neuroinflammation | regulates | disease | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Als | contributes_to | disease | 1.00 |
| Neuroinflammation | contributes_to | disease | 1.00 |
| Inflammation | contributes_to | disease | 1.00 |
| Synaptic Plasticity | activates | pathway | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| Alzheimer | contributes_to | disease | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Stroke | therapeutic_target | disease | 1.00 |
| Multiple Sclerosis | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Parkinson | therapeutic_target | disease | 1.00 |
| Alzheimer | regulates | disease | 1.00 |
| Dementia | regulates | disease | 1.00 |
| Alzheimer | associated_with | disease | 1.00 |
| Neurodegeneration | associated_with | disease | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MICROGLIA | associated_with | gene | 1.00 |
| APP | associated_with | gene | 1.00 |
| MITOCHONDRIA | associated_with | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| AGING | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| PHAGOCYTOSIS | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| CYTOKINES | regulates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| STAT3 | activates | gene | 1.00 |
| MICROGLIA | inhibits | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| NEUROTOXICITY | activates | gene | 1.00 |
| BDNF | activates | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| TAU | therapeutic_target | gene | 1.00 |
| ALZHEIMER'S DISEASE | contributes_to | gene | 1.00 |
| APP | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | therapeutic_target | gene | 1.00 |
| ALZHEIMER'S DISEASE | regulates | gene | 1.00 |
| ALZHEIMER'S DISEASE | associated_with | gene | 1.00 |
| TAU | associated_with | gene | 1.00 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 1.00 |
| NEURODEGENERATION | associated_with | gene | 1.00 |
| AGING | regulates | gene | 1.00 |
| MICROGLIA ACTIVATION | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | activates | gene | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 1.00 |
| TAU | activates | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| COMPLEMENT | activates | gene | 1.00 |
| NLRP3 | activates | gene | 1.00 |
| TLR4 | activates | gene | 1.00 |
| NF-ΚB | inhibits | gene | 1.00 |
| APP/PS1 | activates | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | associated_with | gene | 1.00 |
| TREM2 | activates | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone | 0.645 | neurodegeneration | What are the precise temporal dynamics o |
| STING Antagonism Prevents Acute-to-Chronic Neuroinflammation | 0.605 | neuroinflammation | What molecular mechanisms drive the tran |
| Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 | 0.601 | neurodegeneration | What are the mechanisms by which gut mic |
| Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio | 0.486 | translational neuroscience | Which metabolic biomarkers can distingui |
| Cardiovascular-Neuroinflammation Crosstalk Interruption | 0.437 | Alzheimer's disease | Neuroinflammation and microglial priming |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.605
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.632
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.473
neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.584
neurodegeneration | 2026-04-11 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Complement C1q-Targeted Microglial Membrane Camouflaged Nanolipid Carriers for S [PMID:41114949] | Ding YN, Li MQ, Ding PT, Wang P, Guan PP | Nano letters | 2026 | 1 |
| Systemic inflammation as a central player in the initiation and development of A [PMID:40841660] | Bayraktaroglu I, Ortí-Casañ N, Van Dam D | Immunity & ageing : I & A | 2025 | 1 |
| Cerium-doped Prussian blue biomimetic nanozyme as an amplified pyroptosis inhibi [PMID:40050873] | Ma J, Tian Y, Du C, Zhu Y, Huang W, Ding | Journal of nanobiotechnology | 2025 | 1 |
| Interactions between antidiabetes medications and heart-brain axis. [PMID:39639832] | Ong LT, Sia CH | Current opinion in endocrinolo | 2025 | 1 |
| The Molecular Mechanisms of Cognitive Dysfunction in Long COVID: A Narrative Rev [PMID:40507911] | Popa E, Popa AE, Poroch M, Poroch V, Ung | International journal of molec | 2025 | 1 |
| Air pollution, glymphatic impairment, and Alzheimer's disease. [PMID:37777345] | Hussain R, Graham U, Elder A, Nedergaard | Trends in neurosciences | 2023 | 0 |
| Molecular biomarkers for vascular cognitive impairment and dementia. [PMID:37957261] | Hosoki S, Hansra GK, Jayasena T, Poljak | Nature reviews. Neurology | 2023 | 0 |