Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about P53 PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | P53 PATHWAY |
| Key Genes/Proteins | SIRT1, AMPK, MYC, TP53 |
| Related Diseases | APOPTOSIS, OXIDATIVE STRESS, ALZHEIMER'S DISEASE |
Knowledge base pages for this entity
graph TD
P53_PATHWAY["P53 PATHWAY"]
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| P53_PATHWAY
AND["AND"] -->|"activates"| P53_PATHWAY
APP_PS1["APP/PS1"] -->|"activates"| P53_PATHWAY
APP["APP"] -->|"activates"| P53_PATHWAY
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| P53_PATHWAY
AGING["AGING"] -->|"activates"| P53_PATHWAY
ALZHEIMER["ALZHEIMER"] -->|"activates"| P53_PATHWAY
ROS["ROS"] -->|"activates"| P53_PATHWAY
DEMENTIA["DEMENTIA"] -->|"activates"| P53_PATHWAY
P53["P53"] -->|"activates"| P53_PATHWAY| Source | Relation | Type | Str |
|---|---|---|---|
| SIRT1 | inhibits | gene | 0.65 |
| OXIDATIVE STRESS | associated_with | phenotype | 0.45 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||