concept

SYNUCLEINOPATHY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNUCLEINOPATHY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

482Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

SYNUCLEINOPATHY is a concept in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Aging, Als, Alzheimer. Connected to 118 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	SYNUCLEINOPATHY
Key Genes/Proteins	PARKINSON'S DISEASE
Related Diseases	Neurodegeneration, Synucleinopathy, Als, Parkinson, Tauopathy

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SYNUCLEINOPATHY["SYNUCLEINOPATHY"]
    SYNUCLEINOPATHY -->|"inhibits"| Synucleinopathy["Synucleinopathy"]
    SYNUCLEINOPATHY -->|"activates"| Neurodegeneration["Neurodegeneration"]
    SYNUCLEINOPATHY -->|"inhibits"| Tauopathy["Tauopathy"]
    SYNUCLEINOPATHY -->|"activates"| Autophagy["Autophagy"]
    SYNUCLEINOPATHY -->|"activates"| Phagocytosis["Phagocytosis"]
    SYNUCLEINOPATHY -->|"activates"| Immune_Response["Immune Response"]
    SYNUCLEINOPATHY -->|"activates"| ASTROCYTE["ASTROCYTE"]
    SYNUCLEINOPATHY -->|"inhibits"| ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    SYNUCLEINOPATHY -->|"inhibits"| TAU["TAU"]
    SYNUCLEINOPATHY -->|"activates"| AMYLOID_BETA["AMYLOID-BETA"]
    BMAL1["BMAL1"] -->|"inhibits"| SYNUCLEINOPATHY
    BAG3["BAG3"] -->|"activates"| SYNUCLEINOPATHY
    CLOCK["CLOCK"] -->|"activates"| SYNUCLEINOPATHY
    TFR1["TFR1"] -->|"activates"| SYNUCLEINOPATHY
    GPX4["GPX4"] -->|"activates"| SYNUCLEINOPATHY
    MLKL["MLKL"] -->|"activates"| SYNUCLEINOPATHY
    RIPK3["RIPK3"] -->|"activates"| SYNUCLEINOPATHY
    GENES["GENES"] -->|"activates"| SYNUCLEINOPATHY
    CTSD["CTSD"] -->|"activates"| SYNUCLEINOPATHY
    SNCA["SNCA"] -->|"activates"| SYNUCLEINOPATHY

Outgoing (217)

Target	Relation	Type	Str
Neurodegeneration	activates	disease	0.75
Synucleinopathy	therapeutic_target	disease	0.75
Als	causes	disease	0.75
Synucleinopathy	activates	disease	0.75
Parkinson	activates	disease	0.75
Neurodegeneration	causes	disease	0.75
Parkinson	associated_with	disease	0.75
Synucleinopathy	associated_with	disease	0.75
Synucleinopathy	inhibits	disease	0.65
Tauopathy	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Parkinson	causes	disease	0.65
Tauopathy	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	causes	disease	0.65
Synucleinopathy	causes	disease	0.65
Parkinson	inhibits	disease	0.65
Synucleinopathy	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Parkinson	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Ms	activates	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Ataxia	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Ms	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Synucleinopathy	regulates	disease	0.65
ALS	activates	disease	0.65
Inflammation	regulates	disease	0.65
Neurodegeneration	phosphorylates	disease	0.65
Parkinson	phosphorylates	disease	0.65
Huntington	associated_with	disease	0.65
Lewy Body	associated_with	disease	0.65
Tauopathy	associated_with	disease	0.65

Incoming (265)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
PARKINSON	activates	gene	0.70
ALPHA-SYNUCLEIN	activates	gene	0.70
PARKINSON'S DISEASE	associated_with	gene	0.70
PARKINSON	associated_with	gene	0.70
NEURON	expressed_in	cell_type	0.65
NEURONS	expressed_in	cell_type	0.65
DOPAMINERGIC	causes	cell_type	0.65
ALPHA-SYNUCLEIN	co_discussed	gene	0.60
AMYLOID	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
BMAL1	inhibits	gene	0.60
AMYLOID	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
BAG3	activates	gene	0.60
CLOCK	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
TAUOPATHY	inhibits	gene	0.60
ALPHA-SYNUCLEIN	inhibits	gene	0.60
TAU	activates	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
PARKINSON	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
NEURODEGENERATIVE DISEASES	causes	gene	0.60
INFLAMMATION	activates	gene	0.60
GENES	causes	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
TAUOPATHY	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PINK1	inhibits	gene	0.60
MITOPHAGY	inhibits	gene	0.60
NEURODEGENERATION	causes	gene	0.60
PARKINSON'S DISEASE	inhibits	gene	0.60
PARKINSON	inhibits	gene	0.60
PARKIN	inhibits	gene	0.60
SNCA	inhibits	gene	0.60
USP30	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	causes	gene	0.60
MITOCHONDRIA	causes	gene	0.60
NEURODEGENERATIVE DISORDERS	causes	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
TAU	associated_with	gene	0.60
DEMENTIA	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
TAU PATHOLOGY	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
NEURON	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SYNUCLEINOPATHY

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

CBS/PSP Supplements Guide

Atypical Parkinsonism

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

nhp-validation-animal-model

neuroinflammation

Multiple System Atrophy

TREM2 Mechanism Hub

CBS/PSP Clinical Trials Guide

Circadian Rhythm in Neurodegeneration