gene

DHCR24

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DHCR24: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

120Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

Summary

DHCR24 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, implicated in, associated with. Associated with AD, ALS, AMI. Connected to 72 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	DHCR24
Full Name	24-Dehydrocholesterol Reductase
Chromosome	1p31.3
Protein Family	FAD-dependent oxidoreductases
Protein Type	Enzyme
Function	encodes an enzyme involved in the final step of cholesterol biosynthesis, converting 24-dehydrocholesterol to cholesterol.
Primary Expression	the brain and essential for neuronal survival
Subcellular Localization	Endoplasmic reticulum, lipid rafts
Molecular Weight	~56 kDa (489 amino acids)
Amino Acids	489 aa
Pathways	Viral Uptake, epigenetic regulation, unfolded protein response
UniProt ID	Q8N0Y2
NCBI Gene ID	1719
Ensembl ID	ENSG00000116133
OMIM	606417
GeneCards	DHCR24
Human Protein Atlas	DHCR24
Associated Diseases	AD, AMI, Als, Alzheimer, Alzheimer's disease, RA
Known Drugs/Compounds	rapamycin
Interactions	MAPT, PARP1, PEN2, PSEN1, DAPK1, HSPG2
KG Connections	120 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DHCR24 — AlphaFold Q8N0Y2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DHCR24["DHCR24"] -->|"interacts"| Alzheimer["Alzheimer"]
    DHCR24["DHCR24"] -->|"interacts"| Tumor["Tumor"]
    DHCR24["DHCR24"] -->|"interacts"| Als["Als"]
    DHCR24["DHCR24"] -->|"expressed in"| Atherosclerosis["Atherosclerosis"]
    DHCR24["DHCR24"] -->|"interacts"| ALS["ALS"]
    DHCR24["DHCR24"] -->|"associated"| HMGCR["HMGCR"]
    NCSTN["NCSTN"] -->|"interacts"| DHCR24["DHCR24"]
    FAS["FAS"] -->|"interacts"| DHCR24["DHCR24"]
    TNF["TNF"] -->|"interacts"| DHCR24["DHCR24"]
    LMNA["LMNA"] -->|"interacts"| DHCR24["DHCR24"]
    style DHCR24 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (73)

Target	Relation	Type	Str
Viral Uptake	involved_in	mechanism	0.80
ALZHEIMER'S DISEASE	associated_with	entity	0.70
Alzheimer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
ALS	interacts_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	methylates	disease	0.65
HMGCR	associated_with	gene	0.60
MAPT	interacts_with	gene	0.60
PARP1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
NCSTN	interacts_with	gene	0.60
PSEN2	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	associated_with	gene	0.60
FAS	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
LDLR	associated_with	gene	0.60
SREBF2	associated_with	gene	0.60
LPL	associated_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
ABCG1	associated_with	gene	0.60
APOE	associated_with	gene	0.60
ABCG1	methylates	gene	0.60
LDLR	methylates	gene	0.60
Kinesin	interacts_with	protein	0.60
PSD95	targets	gene	0.60
PSD95	expressed_in	gene	0.60
Cholesterol	associated_with	pathway	0.60
Apoptosis	interacts_with	pathway	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
DNA	interacts_with	gene	0.60
Amyloid	interacts_with	pathway	0.60
Lipid Metabolism	expressed_in	pathway	0.60
Cholesterol	expressed_in	pathway	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60

Incoming (47)

Source	Relation	Type	Str
NCSTN	interacts_with	gene	0.60
FAS	interacts_with	gene	0.60
TNF	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
APH1B	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
IL6	interacts_with	gene	0.60
SREBF1	associated_with	gene	0.60
PSEN2	interacts_with	gene	0.60
A2M	interacts_with	gene	0.60
ABCA1	associated_with	gene	0.60
MAPT	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
IL1B	interacts_with	gene	0.60
HMGCR	associated_with	gene	0.60
PARP1	interacts_with	gene	0.60
DYNEIN	interacts_with	gene	0.60
HSPG2	interacts_with	gene	0.60
DAPK1	interacts_with	gene	0.60
PSEN1	interacts_with	gene	0.60
PEN2	interacts_with	gene	0.60
EIF2AK2	interacts_with	gene	0.60
APOE	associated_with	gene	0.60
ABCG1	associated_with	gene	0.60
LDLR	associated_with	gene	0.60
APOE	methylates	gene	0.60
BDNF	targets	gene	0.60
BDNF	expressed_in	gene	0.60
ACC	expressed_in	gene	0.60
DNA	interacts_with	gene	0.60
MITOCHONDRIAL DNA	interacts_with	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
TFCP2	interacts_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
DNA	associated_with	gene	0.60
APOE Ε4	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ALZHEIMER	methylates	gene	0.60
DNA	methylates	gene	0.60
rapamycin	targets	drug	0.60
APOE4	activates	gene	0.55
late	associated_with	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DHCR24

Understanding Entity Pages

Summary

Wiki Pages (9)

DHCR24 Gene

PSEN2 — Presenilin 2

A2M Gene

PSEN2 Protein (Presenilin-2)

Presenilin-2 (PSEN2)

APH1B Gene - Anterior Pharynx Defective 1 Homolog B

DHCR24 Protein