Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DIABETES MELLITUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DIABETES MELLITUS is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, associated with. Associated with ALS, Aging, Als. Connected to 770 entities in the SciDEX knowledge graph.
| Name | DIABETES MELLITUS |
| Key Genes/Proteins | DIABETIC RETINOPATHY |
| Related Diseases | Diabetes, Als, Cancer, Aging, Inflammation |
| Related Pathways | Oxidative Stress |
Knowledge base pages for this entity
graph TD
DIABETES_MELLITUS["DIABETES MELLITUS"]
DIABETES_MELLITUS -->|"causes"| DIABETIC_RETINOPATHY["DIABETIC RETINOPATHY"]
DIABETES_MELLITUS -->|"target for"| Fibrosis["Fibrosis"]
DIABETES_MELLITUS -->|"activates"| Cardiovascular["Cardiovascular"]
DIABETES_MELLITUS -->|"activates"| Neuropathy["Neuropathy"]
DIABETES_MELLITUS -->|"activates"| Als["Als"]
DIABETES_MELLITUS -->|"activates"| Cancer["Cancer"]
DIABETES_MELLITUS -->|"target for"| Ms["Ms"]
MTOR["MTOR"] -->|"target for"| DIABETES_MELLITUS
MTORC1["MTORC1"] -->|"target for"| DIABETES_MELLITUS
TXNIP["TXNIP"] -->|"target for"| DIABETES_MELLITUS
NOX4["NOX4"] -->|"activates"| DIABETES_MELLITUS
PI3K["PI3K"] -->|"activates"| DIABETES_MELLITUS
AKT["AKT"] -->|"activates"| DIABETES_MELLITUS
NF__B["NF-KappaB"] -->|"activates"| DIABETES_MELLITUS
OXIDATIVE_STRESS["OXIDATIVE STRESS"] -->|"target for"| DIABETES_MELLITUS| Target | Relation | Type | Str |
|---|---|---|---|
| DIABETIC RETINOPATHY | causes | gene | 1.00 |
| Diabetes | associated_with | disease | 1.00 |
| Oxidative Stress | therapeutic_target | pathway | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Diabetes | therapeutic_target | disease | 1.00 |
| Diabetes | activates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| Diabetes | regulates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Cardiovascular | therapeutic_target | disease | 1.00 |
| Obesity | associated_with | disease | 1.00 |
| Diabetes | causes | disease | 1.00 |
| Type 2 Diabetes | associated_with | disease | 1.00 |
| Insulin Resistance | associated_with | disease | 1.00 |
| Type 2 Diabetes | therapeutic_target | disease | 1.00 |
| Type 2 Diabetes | activates | disease | 1.00 |
| Als | treats | disease | 1.00 |
| Hypertension | associated_with | disease | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| Cardiovascular | activates | disease | 0.95 |
| Als | activates | disease | 0.95 |
| Diabetes | inhibits | disease | 0.95 |
| Cardiovascular | associated_with | disease | 0.95 |
| Inflammation | inhibits | disease | 0.95 |
| Inflammation | contributes_to | disease | 0.95 |
| Fibrosis | associated_with | disease | 0.95 |
| Diabetes | biomarker_for | disease | 0.95 |
| Inflammation | causes | disease | 0.95 |
| Hypertension | causes | disease | 0.95 |
| Type 2 Diabetes | contributes_to | disease | 0.95 |
| Stroke | activates | disease | 0.95 |
| Insulin Resistance | therapeutic_target | disease | 0.95 |
| Insulin Resistance | activates | disease | 0.95 |
| Obesity | activates | disease | 0.95 |
| INFLAMMATION | inhibits | gene | 0.90 |
| Lipid Metabolism | therapeutic_target | pathway | 0.90 |
| Oxidative Stress | activates | pathway | 0.90 |
| INFLAMMATION | contributes_to | gene | 0.90 |
| INFLAMMATION | causes | gene | 0.90 |
| INFLAMMATION | activates | gene | 0.90 |
| MTOR | therapeutic_target | gene | 0.90 |
| Fibrosis | therapeutic_target | disease | 0.85 |
| Neuropathy | activates | disease | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| OXIDATIVE STRESS | therapeutic_target | gene | 1.00 |
| INSULIN RESISTANCE | activates | gene | 0.90 |
| PI3K | activates | gene | 0.80 |
| TNF | activates | gene | 0.80 |
| PI3K | therapeutic_target | gene | 0.80 |
| CYTOKINES | therapeutic_target | gene | 0.80 |
| ROS | activates | gene | 0.80 |
| ALZHEIMER | activates | gene | 0.80 |
| INSULIN RESISTANCE | associated_with | gene | 0.80 |
| INSULIN RESISTANCE | therapeutic_target | gene | 0.80 |
| CYTOKINES | activates | gene | 0.80 |
| IL-6 | activates | gene | 0.80 |
| OXIDATIVE STRESS | activates | gene | 0.80 |
| APOPTOSIS | therapeutic_target | gene | 0.80 |
| AMPK | therapeutic_target | gene | 0.80 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 0.70 |
| UBIQUITIN | regulates | gene | 0.70 |
| AGING | activates | gene | 0.70 |
| PARKINSON'S DISEASE | activates | gene | 0.70 |
| CYTOKINES | associated_with | gene | 0.70 |
| OXIDATIVE STRESS | associated_with | gene | 0.70 |
| AUTOPHAGY | contributes_to | gene | 0.70 |
| NEURODEGENERATION | contributes_to | gene | 0.70 |
| INSULIN RESISTANCE | causes | gene | 0.70 |
| OXIDATIVE STRESS | causes | gene | 0.70 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 0.70 |
| TNF | treats | gene | 0.70 |
| OXIDATIVE STRESS | contributes_to | gene | 0.70 |
| OXIDATIVE STRESS | treats | gene | 0.70 |
| MTOR | therapeutic_target | gene | 0.60 |
| MTORC1 | therapeutic_target | gene | 0.60 |
| TXNIP | therapeutic_target | gene | 0.60 |
| NOX4 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| NF-ΚB | activates | gene | 0.60 |
| INFLAMMATION | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| AKT1 | therapeutic_target | gene | 0.60 |
| EGFR | therapeutic_target | gene | 0.60 |
| ALZHEIMER DISEASE | therapeutic_target | gene | 0.60 |
| TNF | therapeutic_target | gene | 0.60 |
| BAX | inhibits | gene | 0.60 |
| MITOPHAGY | activates | gene | 0.60 |
| PARKIN | activates | gene | 0.60 |
| SIRT3 | activates | gene | 0.60 |
| AGING | therapeutic_target | gene | 0.60 |
| JAK | therapeutic_target | gene | 0.60 |
| SIGLEC1 | therapeutic_target | gene | 0.60 |
| NF-ΚB | regulates | gene | 0.60 |
| FERROPTOSIS | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||