Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ENTORHINAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ENTORHINAL |
| Summary | Comprehensive guide to ADNI, the landmark longitudinal neuroimaging study for Alzheimer's disease research |
| Key Genes/Proteins | GFAP, P2RX7 |
| Linked Hypotheses | 10 hypotheses |
Knowledge base pages for this entity
graph TD
ENTORHINAL["ENTORHINAL"]
ENTORHINAL -->|"reduces"| WHITE_MATTER["WHITE MATTER"]
ENTORHINAL -->|"sensitizes_to"| GFAP["GFAP"]
ENTORHINAL -->|"inhibits"| MICROGLIA["MICROGLIA"]
ENTORHINAL -->|"inhibits"| P2RX7["P2RX7"]
ENTORHINAL -->|"inhibits"| TAU_PROPAGATION["TAU PROPAGATION"]
ASTROCYTE["ASTROCYTE"] -->|"expressed in"| ENTORHINAL
ASTROCYTES["ASTROCYTES"] -->|"expressed in"| ENTORHINAL
CORTEX["CORTEX"] -->|"causes"| ENTORHINAL
AMYLOID["AMYLOID"] -->|"causes"| ENTORHINAL| Target | Relation | Type | Str |
|---|---|---|---|
| WHITE MATTER | reduces | brain_region | 0.65 |
| GFAP | sensitizes_to | gene | 0.65 |
| MICROGLIA | inhibits | cell_type | 0.60 |
| P2RX7 | inhibits | gene | 0.60 |
| GFAP | co_discussed | entity | 0.50 |
| HIPPOCAMPUS | co_discussed | entity | 0.50 |
| WHITE MATTER | co_discussed | brain_region | 0.40 |
| FRONTAL | co_discussed | brain_region | 0.40 |
| NEURON | co_discussed | cell_type | 0.40 |
| NEURONS | co_discussed | cell_type | 0.40 |
| NEURODEGENERATION | co_discussed | disease | 0.40 |
| IBA1 | co_discussed | gene | 0.40 |
| MICROGLIA | co_discussed | cell_type | 0.40 |
| WNT | co_discussed | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CORTEX | associated_with | brain_region | 0.65 |
| ASTROCYTE | expressed_in | cell_type | 0.65 |
| ASTROCYTES | expressed_in | cell_type | 0.65 |
| CORTEX | causes | brain_region | 0.60 |
| ASTROCYTE | inhibits | cell_type | 0.60 |
| ASTROCYTES | inhibits | cell_type | 0.60 |
| ASTROCYTE | co_discussed | entity | 0.50 |
| ASTROCYTES | co_discussed | entity | 0.50 |
| CORTEX | co_discussed | entity | 0.50 |
| ALZHEIMER | co_discussed | disease | 0.40 |
| ALZHEIMER'S | co_discussed | disease | 0.40 |
| ALZHEIMER'S DISEASE | co_discussed | disease | 0.40 |
| CEREBELLUM | co_discussed | brain_region | 0.40 |
| APP | co_discussed | gene | 0.40 |
| CA1 | co_discussed | brain_region | 0.40 |
| APOE | co_discussed | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop tACS targeting entorhinal cortex layer II SST in | 0.625 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Closed-loop transcranial focused ultrasound targeting EC-II | 0.612 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 0 hypotheses
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.484
neurodegeneration | 2026-04-01 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Anterior cingulate cortex parvalbumin and somatostatin interneurons shape social [PMID:40320404] | Qi C, Sima W, Mao H, Hu E, Ge J et al. | Nat Commun | 2025 | 0 |
| Distinct dendritic integration strategies control dynamics of inhibition in the [PMID:40592329] | Morabito A, Zerlaut Y, Dhanasobhon D, Be | Neuron | 2025 | 0 |
| Cortical somatostatin long-range projection neurons and interneurons exhibit div [PMID:38086373] | Fisher J, Verhagen M, Long Z, Moissidis | Neuron | 2024 | 0 |
| Locus Coeruleus-Dorsolateral Septum Projections Modulate Depression-Like Behavio [PMID:38155473] | Zhang Q, Xue Y, Wei K, Wang H, Ma Y et a | Adv Sci (Weinh) | 2024 | 0 |
| Somatostatin and the pathophysiology of Alzheimer's disease. [PMID:38484981] | Almeida VN | Ageing Res Rev | 2024 | 0 |
| Somatostatin interneurons control the timing of developmental desynchronization [PMID:38599213] | Mòdol L, Moissidis M, Selten M, Oozeer F | Neuron | 2024 | 0 |
| De novo gene synthesis by an antiviral reverse transcriptase. [PMID:39116258] | Tang S, Conte V, Zhang DJ, Žedaveinytė R | Science | 2024 | 0 |
| Novel App knock-in mouse model shows key features of amyloid pathology and revea [PMID:35690868] | Xia D, Lianoglou S, Sandmann T, Calvert | Mol Neurodegener | 2022 | 0 |
| Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149] | Fogaça MV, Wu M, Li C, Li XY, Picciotto | Mol Psychiatry | 2021 | 0 |
| Identification of Faecalibacterium prausnitzii strains for gut microbiome-based [PMID:34622235] | Ueda A, Shinkai S, Shiroma H, Taniguchi | Cell Rep Med | 2021 | 0 |
| Somatostatin, Olfaction, and Neurodegeneration. [PMID:32140092] | Saiz-Sanchez D, Ubeda-Bañon I, Flores-Cu | Front Neurosci | 2020 | 0 |
| Somatostatin replacement: a new strategy for treating diabetic retinopathy. [PMID:23745546] | Hernández C, Simó R, European Consortium | Curr Med Chem | 2013 | 0 |