concept

GLUCOSE METABOLISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUCOSE METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections

0Hypotheses

2Analyses

4Outgoing

38Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GLUCOSE METABOLISM
Key Genes/Proteins	APOE4
Related Diseases	DEPRESSION, cancer, hand, TUMOR
Related Pathways	Pi3K, Pi3K/Akt, Neuroinflammatory

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GLUCOSE_METABOLISM["GLUCOSE METABOLISM"]
    style GLUCOSE_METABOLISM fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    GLUCOSE_METABOLISM -->|"contributes to"| NEURODEGENERATION["NEURODEGENERATION"]
    GLUCOSE_METABOLISM -->|"mediates"| Glucose_Stimulated_Insulin_Sec["Glucose-Stimulated Insulin Secretion"]
    GLUCOSE_METABOLISM -->|"regulates"| Oligodendrocyte_Function(Oligodendrocyte Function)
    GLUCOSE_METABOLISM -->|"regulates"| Myelin_Synthesis["Myelin Synthesis"]
    GLUCOSE_METABOLISM -->|"modulates"| Microglia_Activation["Microglia Activation"]
    GLUCOSE_METABOLISM -->|"regulates"| Microglial_Activation["Microglial Activation"]
    GLUCOSE_METABOLISM -->|"treats"| MICROGLIA["/MICROGLIA/"]
    GLUCOSE_METABOLISM -->|"regulates"| TUMOR["TUMOR"]
    AKT["AKT"] -->|"regulates"| GLUCOSE_METABOLISM
    Microglia["/Microglia/"] -->|"regulates"| GLUCOSE_METABOLISM
    STAT3([STAT3]) -->|"regulates"| GLUCOSE_METABOLISM
    AMPK([AMPK]) -->|"regulates"| GLUCOSE_METABOLISM
    O_GlcNAc["O-GlcNAc"] -->|"involved_in"| GLUCOSE_METABOLISM
    OGDHL([OGDHL]) -->|"regulates"| GLUCOSE_METABOLISM
    P2RX7([P2RX7]) -->|"regulates"| GLUCOSE_METABOLISM
    Autophagy["Autophagy"] -->|"regulates"| GLUCOSE_METABOLISM

Outgoing (19)

Target	Relation	Type	Str
NEURODEGENERATION	contributes_to	entity	0.95
DEPRESSION	implicated_in	disease	0.70
MICROGLIA	co_discussed	entity	0.50
MS	co_discussed	entity	0.50

Incoming (82)

Source	Relation	Type	Str
AKT	regulates	entity	0.95
Pi3K	associated_with	pathway	0.50
cancer	associated_with	disease	0.50
Pi3K/Akt	associated_with	pathway	0.50
PI3K/AKT PATHWAY	associated_with	concept	0.50
microglia	associated_with	cell_type	0.50
hand	regulates	disease	0.50
TUMOR	regulates	disease	0.50
Neuroinflammatory	regulates	pathway	0.50
FLAVONOIDS	regulates	concept	0.50
APOE4	inhibits	gene	0.50
APOE	inhibits	gene	0.50
Cerebrovascular	inhibits	pathway	0.50
INSULIN	activates	concept	0.50
PERK	activates	gene	0.50
Oligodendrocyte	associated_with	cell_type	0.50
MYELIN	associated_with	concept	0.50
DIABETES	inhibits	disease	0.50
Insulin Resistance	inhibits	disease	0.50
disease	inhibits	disease	0.50
INSULIN	inhibits	concept	0.50
AMPK	associated_with	protein	0.50
DIABETES	interacts_with	disease	0.50
Cognitive Decline	interacts_with	disease	0.50
FGFR1	activates	gene	0.50
FGF21	activates	gene	0.50
Fibroblast	activates	cell_type	0.50
GLUT4	activates	concept	0.50
FGFR1	inhibits	gene	0.50
GLUT4	inhibits	concept	0.50
PCK1	regulates	concept	0.50
Neuroinflammation	associated_with	process	0.50
Insulin Signaling	activates	pathway	0.50
OBESITY	regulates	disease	0.50
NEURONS	regulates	concept	0.50
AKT	co_discussed	entity	0.50
ALS	co_discussed	entity	0.50
APOE	co_discussed	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Metabolomic signatures of neurodegeneration and energy metabolism dysfunction

neurodegeneration | 2026-04-04 | 0 hypotheses

Metabolic reprogramming in neurodegenerative disease

neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.398

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GLUCOSE METABOLISM

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

primary-progressive-aphasia

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

nhp-validation-animal-model

nct07165106

GSK-3β in Neurodegeneration

Growth Factor Therapies

Mitochondrial Dysfunction in Parkinson's Disease

Circadian Rhythm in Neurodegeneration

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

APOC4 — Apolipoprotein C-IV

Huntington's Disease

DIAN-TU-001 Trial (NCT01760005)

AI and Machine Learning in Neurodegeneration

Lithium for PSP/CBS — Phase 2 Trial

Epigenetic Dysregulation in Neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

A Phase 3, Randomised, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy, Tolerability, and Safety of Combined Metabolic Activator Supplementation in Subjects Diagnosed With Alzheimer's Disease