Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SEEDING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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graph TD
SEEDING["SEEDING"]
SEEDING -->|"causes"| TAU_PROPAGATION["TAU PROPAGATION"]
SEEDING -->|"promotes"| STING["STING"]
SEEDING -->|"expressed in"| TREM2["TREM2"]
NEURON["NEURON"] -->|"mediates"| SEEDING
ALZHEIMER["ALZHEIMER"] -->|"expressed in"| SEEDING
ALZHEIMER_S["ALZHEIMER'S"] -->|"expressed in"| SEEDING
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| SEEDING
MICROGLIA["MICROGLIA"] -->|"expressed in"| SEEDING| Target | Relation | Type | Str |
|---|---|---|---|
| STING | co_discussed | entity | 0.50 |
| VCP | co_discussed | entity | 0.50 |
| SENESCENCE | co_discussed | entity | 0.50 |
| SLEEP | co_discussed | entity | 0.50 |
| TDP-43 | co_discussed | entity | 0.50 |
| T CELL | co_discussed | entity | 0.50 |
| T CELLS | co_discussed | entity | 0.50 |
| SNCA | co_discussed | entity | 0.50 |
| SOD1 | co_discussed | entity | 0.50 |
| SQSTM1 | co_discussed | entity | 0.50 |
| WHITE MATTER | co_discussed | entity | 0.50 |
| TAU | co_discussed | entity | 0.50 |
| TAU PROPAGATION | co_discussed | entity | 0.50 |
| TREM2 | co_discussed | entity | 0.50 |
| SYNAPSE | co_discussed | entity | 0.50 |
| THALAMUS | co_discussed | entity | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PSEN1 | co_discussed | entity | 0.50 |
| ALZHEIMER | co_discussed | entity | 0.50 |
| ALZHEIMER'S | co_discussed | entity | 0.50 |
| INFLAMMASOME | co_discussed | entity | 0.50 |
| GBA | co_discussed | entity | 0.50 |
| LRRK2 | co_discussed | entity | 0.50 |
| CORTEX | co_discussed | entity | 0.50 |
| ENTORHINAL | co_discussed | entity | 0.50 |
| ALS | co_discussed | entity | 0.50 |
| PARKINSON | co_discussed | entity | 0.50 |
| PARKINSON'S | co_discussed | entity | 0.50 |
| PROTEOSTASIS | co_discussed | entity | 0.50 |
| DLB | co_discussed | entity | 0.50 |
| DEMENTIA | co_discussed | entity | 0.50 |
| PSP | co_discussed | entity | 0.50 |
| MAPT | co_discussed | entity | 0.50 |
| OPTN | co_discussed | entity | 0.50 |
| DEMYELINATION | co_discussed | entity | 0.50 |
| MYELINATION | co_discussed | entity | 0.50 |
| REMYELINATION | co_discussed | entity | 0.50 |
| CHOLESTEROL | co_discussed | entity | 0.50 |
| AMYGDALA | co_discussed | entity | 0.50 |
| BASAL GANGLIA | co_discussed | entity | 0.50 |
| MITOCHONDRIA | co_discussed | entity | 0.50 |
| OXIDATIVE STRESS | co_discussed | entity | 0.50 |
| MS | co_discussed | entity | 0.50 |
| OLIGODENDROCYTE | co_discussed | entity | 0.50 |
| OLIGODENDROCYTES | co_discussed | entity | 0.50 |
| NLRP3 | co_discussed | entity | 0.50 |
| PRION-LIKE | co_discussed | entity | 0.50 |
| NEURON | co_discussed | entity | 0.50 |
| NEURONS | co_discussed | entity | 0.50 |
| MICROGLIA | co_discussed | entity | 0.50 |
| APOE | co_discussed | entity | 0.50 |
| LRP1 | co_discussed | entity | 0.50 |
| ALPHA-SYNUCLEIN | co_discussed | entity | 0.50 |
| MACROPHAGES | co_discussed | entity | 0.50 |
| MACROPHAGE | co_discussed | entity | 0.50 |
| ASTROCYTE | co_discussed | entity | 0.50 |
| ASTROCYTES | co_discussed | entity | 0.50 |
| P62 | co_discussed | entity | 0.50 |
| AXON | co_discussed | entity | 0.50 |
| CBD | co_discussed | entity | 0.50 |
| NEURODEGENERATION | co_discussed | entity | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity