concept

SEEDING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SEEDING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

20Hypotheses

0Analyses

16Outgoing

46Incoming

11Experiments

0Debates

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💡 Concept Info

Name	SEEDING

Pathway Diagram

graph TD
    SEEDING["SEEDING"]
    SEEDING -->|"causes"| TAU_PROPAGATION["TAU PROPAGATION"]
    SEEDING -->|"promotes"| STING["STING"]
    SEEDING -->|"expressed in"| TREM2["TREM2"]
    NEURON["NEURON"] -->|"mediates"| SEEDING
    ALZHEIMER["ALZHEIMER"] -->|"expressed in"| SEEDING
    ALZHEIMER_S["ALZHEIMER'S"] -->|"expressed in"| SEEDING
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| SEEDING
    MICROGLIA["MICROGLIA"] -->|"expressed in"| SEEDING

Outgoing (16)

Target	Relation	Type	Str
TAU PROPAGATION	co_discussed	entity	0.50
T CELL	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
VCP	co_discussed	entity	0.50
TAU	co_discussed	entity	0.50
SQSTM1	co_discussed	entity	0.50
SNCA	co_discussed	entity	0.50
TDP-43	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
TREM2	co_discussed	entity	0.50
SOD1	co_discussed	entity	0.50
SENESCENCE	co_discussed	entity	0.50
SLEEP	co_discussed	entity	0.50
SYNAPSE	co_discussed	entity	0.50
WHITE MATTER	co_discussed	entity	0.50
THALAMUS	co_discussed	entity	0.50

Incoming (46)

Source	Relation	Type	Str
PRION-LIKE	co_discussed	entity	0.50
NEURON	co_discussed	entity	0.50
NEURODEGENERATION	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
PSEN1	co_discussed	entity	0.50
ALZHEIMER	co_discussed	entity	0.50
ALZHEIMER'S	co_discussed	entity	0.50
INFLAMMASOME	co_discussed	entity	0.50
DEMYELINATION	co_discussed	entity	0.50
MYELINATION	co_discussed	entity	0.50
REMYELINATION	co_discussed	entity	0.50
CORTEX	co_discussed	entity	0.50
ENTORHINAL	co_discussed	entity	0.50
ASTROCYTE	co_discussed	entity	0.50
ASTROCYTES	co_discussed	entity	0.50
P62	co_discussed	entity	0.50
AXON	co_discussed	entity	0.50
PROTEOSTASIS	co_discussed	entity	0.50
DLB	co_discussed	entity	0.50
DEMENTIA	co_discussed	entity	0.50
PSP	co_discussed	entity	0.50
CBD	co_discussed	entity	0.50
AMYGDALA	co_discussed	entity	0.50
BASAL GANGLIA	co_discussed	entity	0.50
MACROPHAGES	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
MAPT	co_discussed	entity	0.50
OPTN	co_discussed	entity	0.50
MITOCHONDRIA	co_discussed	entity	0.50
OXIDATIVE STRESS	co_discussed	entity	0.50
MS	co_discussed	entity	0.50
GBA	co_discussed	entity	0.50
LRRK2	co_discussed	entity	0.50
CHOLESTEROL	co_discussed	entity	0.50
NLRP3	co_discussed	entity	0.50
C9ORF72	co_discussed	entity	0.50
PHAGOCYTOSIS	co_discussed	entity	0.50
NEURONS	co_discussed	cell_type	0.50
APOE	co_discussed	entity	0.50
LRP1	co_discussed	entity	0.50
ALPHA-SYNUCLEIN	co_discussed	entity	0.50
OLIGODENDROCYTE	co_discussed	entity	0.50
OLIGODENDROCYTES	co_discussed	entity	0.50
ALS	co_discussed	entity	0.50
PARKINSON	co_discussed	entity	0.50
PARKINSON'S	co_discussed	entity	0.50

Targeting Hypotheses (20)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop focused ultrasound targeting EC-II PV interneuro	0.863	alzheimers	Circuit-level neural dynamics in neurode
MAPT tau seeding and release across AD, FTD, and PD-spectrum	0.812	multi	Cross-disease neurodegeneration mechanis
H3: G3BP1 as Nucleation Hub for TDP-43/FUS Seeding	0.743	neurodegeneration	How do pathological stress granules tran
Tau missorting transitions into an autonomous tau-seeding st	0.740	neurodegeneration	Does tau dendritic missorting persist in
Cross-Seeding Prevention Strategy	0.689	neurodegeneration	RNA binding protein dysregulation across

Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro	0.642	neurodegeneration	What are the mechanisms by which gut mic
H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seed	0.640	neurodegeneration	Entorhinal cortex layer II vulnerability
Tau Cross-Seeding and Interaction	0.610	neurodegeneration	What mechanisms underlie TDP-43's contri
Peri-plaque tau seeding restraint via TREM2-competent microg	0.590	neurodegeneration	Does the cancer-cystatin-C-TREM2 pathway
HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor	0.544	neurodegeneration	Protein aggregation cross-seeding across
Cross-Seeding: Gut Microbiome-Derived Bacterial Curli and Fu	0.540	neurodegeneration	How does gut microbiome dysbiosis contri
G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-	0.490	neurodegeneration	How do disease-associated mutations in G
Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption	0.469	neurodegeneration	Protein aggregation cross-seeding across
RNA-Binding Competition Therapy for TDP-43 Cross-Seeding	0.465	neurodegeneration	Protein aggregation cross-seeding across
Galectin-3 as Damage-Sensor Scaffold for Multimeric Cross-Se	0.455	neurodegeneration	Protein aggregation cross-seeding across
Membrane Lipid Composition-Dependent Specificity Switch Enab	0.455	neurodegeneration	Protein aggregation cross-seeding across
RNA Granule Phase Separation as Transient Cross-Seeding Hub	0.455	neurodegeneration	Protein aggregation cross-seeding across
Direct APOE4-TDP-43 Protein-Protein Interaction Promoting Ag	0.360	neurodegeneration	How does APOE4 mechanistically increase
Lysosomal Membrane Stabilization to Prevent Tau Seeding	0.000	-	Tau propagation mechanisms and therapeut
Cross-Seeding Autophagy Specificity Enhancement	0.000	-	Autophagy-lysosome pathway convergence a

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (11)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Nation-wide NGS-based genetic screening of LGMD patients in US	exploratory	Limb-girdle muscular dystrophy	0.950	0.00	Human patients	proposed	N/A
TDP-43 mutant mouse model cGAS/STING pathway analysis	validation	amyotrophic lateral sclerosis	0.900	0.00	TDP-43 mutant mice	proposed	N/A
TDP-43 mitochondrial invasion and DNA release via mPTP	exploratory	amyotrophic lateral sclerosis	0.900	0.00	cultured cells	proposed	N/A
TDP-43 mitochondrial invasion and mtDNA release in iPSC motor neurons	exploratory	Amyotrophic Lateral Sclerosis	0.900	0.00	iPSC-derived motor neurons	proposed	N/A
cGAS/STING pathway validation in TDP-43 mutant mice	validation	Amyotrophic Lateral Sclerosis	0.850	0.00	TDP-43 mutant mice	proposed	N/A
cGAMP biomarker analysis in ALS patient spinal cord samples	exploratory	Amyotrophic Lateral Sclerosis	0.800	0.00	Human ALS patient spinal cord	proposed	N/A
TDP-43 pathology prevalence and distribution in AD cases	exploratory	Alzheimer's disease	0.800	0.00	human postmortem brain tissue	proposed	N/A
Cognitive impact of TDP-43 pathology in AD patients	clinical	Alzheimer's disease	0.700	0.00	human patients	completed	N/A
Proposed experiment from debate on TDP-43 undergoes liquid-liquid phas	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$80,000
s:** - Single-cell RNA-seq to measure editing efficiency across differ	falsification	ALS	0.400	0.50	cell_line	proposed	$150,000
Alpha-Synuclein SAA Kinetics Study — Biological Staging Backbone for P	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Autophagy and ALS: mechanistic insights and therapeutic implications. [PMID:34057020]	Chua JP, De Calbiac H, Kabashi E, Barmad	Autophagy	2022	2
TDP-43 Pathology in Alzheimer's Disease. [PMID:34930382]	Meneses A, Koga S, O'Leary J, Dickson DW	Mol Neurodegener	2021	2
Protein transmission in neurodegenerative disease. [PMID:32203399]	Peng C, Trojanowski JQ, Lee VM	Nat Rev Neurol	2020	2
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745]	Yu CH, Davidson S, Harapas CR, Hilton JB	Cell	2020	2
N protein of PEDV plays chess game with host proteins by selective autophagy. [PMID:36861818]	Zhai X, Kong N, Zhang Y, Song Y, Qin W,	Autophagy	2023	1
Role of Alpha-Synuclein in Frontotemporal Dementia: Narrative Review. [PMID:41827903]	Bougea A	Cells	2026	0
The Genetics of TDP-43 Type C Neurodegeneration: A Whole-Genome Sequencing Study [PMID:41883703]	Nassan M, Ayala I, Sloan J, Bonfitto A,	Neurology. Genetics	2026	0
Computational examination of magainin-I-KL mediated disruption of E. coli biofil [PMID:41724836]	Vinutha AS, Akshay S, Sree Agash SG, Cha	Archives of microbiology	2026	0
Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progressi [PMID:41540015]	Ni N, Wang M, Yuan Z, Zhang L, Cai J, Du	International journal of oral	2026	0
The cytoplasmic protein YedX is a potent inhibitor of CsgA amyloid assembly in E [PMID:41581877]	Gurnani B, Jain N	The Journal of biological chem	2026	0
DNAJB6: A guardian against neurodegeneration. [PMID:40536953]	Hentze J, Gelman A, Brudek T, Hansen C	Neural regeneration research	2026	0
Biofluid biomarkers in Alzheimer's disease and other neurodegenerative dementias [PMID:41639575]	Zetterberg H, Bendlin BB	Nature	2026	0
Correction: Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibi [PMID:41775718]	Ni Nan; Wang Moxu; Yuan Zhiran; Zhang Le	International journal of oral	2026	0
Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non- [PMID:41271702]	Resnick SJ, Qamar S, Krishna P, Korobeyn	Nature communications	2025	0
Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenera [PMID:40141340]	Singh AA, Khan F, Song M	International journal of molec	2025	0
E.coli-derived CsgA-peptides stimulate cytokine production in microglia and lead [PMID:41476670]	Mygind L, Jensen G, Neesgaard V, Krohn K	Brain, behavior, & immunity -	2025	0
TMEM106B core deposition associates with TDP-43 pathology and is increased in ri [PMID:38232138]	Marks JD, Ayuso VE, Carlomagno Y, Yue M,	Science translational medicine	2024	0
Extracellular chaperone networks and the export of J-domain proteins. [PMID:36581212]	Braun JEA	The Journal of biological chem	2023	0
DNAJB6 mutants display toxic gain of function through unregulated interaction wi [PMID:37923706]	Abayev-Avraham M, Salzberg Y, Gliksberg	Nature communications	2023	0
Evidence-based consensus guidelines for ALS genetic testing and counseling. [PMID:37691292]	Roggenbuck J, Eubank BHF, Wright J, Harm	Annals of clinical and transla	2023	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SEEDING in their description or question text

Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cross-Seeding

Score: 0.642 · neurodegeneration · 2026-04-02

## Mechanistic Overview Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cross-Seeding starts from the claim tha

H7: mTOR Hyperactivity Blocks Autophagy, Permitting Tau Seeding

Score: 0.640 · neurodegeneration · 2026-04-22

**Molecular Mechanism and Rationale** The mechanistic target of rapamycin complex 1 (mTORC1) serves as a critical cellu

Tau Cross-Seeding and Interaction

Score: 0.610 · neurodegeneration · 2026-04-21

## Mechanistic Overview Tau Cross-Seeding and Interaction starts from the claim that modulating MAPT within the disease

Peri-plaque tau seeding restraint via TREM2-competent microglia

Score: 0.590 · neurodegeneration · 2026-04-25

TREM2-activated microglia limit neuritic plaque tau spread around amyloid plaques through enhanced phagocytosis of extra

HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor

Score: 0.544 · neurodegeneration · 2026-04-02

DNAJB6 specifically recognizes and suppresses amyloidogenic β-sheet conformations shared across tau, α-synuclein, and TD

Cross-Seeding: Gut Microbiome-Derived Bacterial Curli and Fungal Amyloid Synergi

Score: 0.540 · neurodegeneration · 2026-04-26

Commensal bacteria (E. coli, Salmonella) produce curli amyloid fibers encoded by the csg operon, while Candida and Sacch

G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-Spreads Across Neura

Score: 0.490 · neurodegeneration · 2026-04-22

## Mechanistic Overview G3BP1-TDP-43 Cross-Seeding Drives Co-Aggregation That Prion-Spreads Across Neural Circuits start

Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption

Score: 0.469 · neurodegeneration · 2026-04-02

Prohibitin-2 serves as a convergent mitochondrial platform where tau, α-synuclein, and TDP-43 interact and undergo confo

RNA-Binding Competition Therapy for TDP-43 Cross-Seeding

Score: 0.465 · neurodegeneration · 2026-04-02

Synthetic RNA aptamers designed to competitively bind TDP-43's RNA recognition motifs could prevent its interaction with

Galectin-3 as Damage-Sensor Scaffold for Multimeric Cross-Seeding at Compromised

Score: 0.455 · neurodegeneration · 2026-04-27

Galectin-3's carbohydrate recognition domain binds exposed glycans on ruptured endolysosomal membranes while its intrins

Membrane Lipid Composition-Dependent Specificity Switch Enabling Cross-Seeding R

Score: 0.455 · neurodegeneration · 2026-04-27

Specific lipid perturbations (bis(monoacylglycero)phosphate enrichment, cardiolipin externalization) create membrane mic

RNA Granule Phase Separation as Transient Cross-Seeding Hub

Score: 0.455 · neurodegeneration · 2026-04-27

Liquid-liquid phase separation of RNA-binding proteins (TDP-43, FUS) creates membrane-less compartments where disease-sp

Direct APOE4-TDP-43 Protein-Protein Interaction Promoting Aggregation Seeding

Score: 0.360 · neurodegeneration · 2026-04-21

## Mechanistic Overview Direct APOE4-TDP-43 Protein-Protein Interaction Promoting Aggregation Seeding starts from the cl

Lysosomal Membrane Stabilization to Prevent Tau Seeding

Score: 0.000 · unknown disease · 2026-04-28

Tau fibrils induce nanoscale membrane damage in lysosomes, leading to cytosolic tau nucleation at damaged lysosomal memb

Cross-Seeding Autophagy Specificity Enhancement

Score: 0.000 · unknown disease · 2026-04-28

Engineering enhanced specificity in autophagy adaptors to selectively target seed-competent species while sparing mature