concept

VASCULAR DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VASCULAR DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

216Connections
0Hypotheses
1Analyses
5Outgoing
9Incoming

No summary available yet. View on Wiki →

💡 Concept Info
NameVASCULAR DEMENTIA
Key Genes/ProteinsMMP9, APOE, APP, CREB
Related DiseasesGLYCOLYSIS, GLUTAMATE, NEUROINFLAMMATION
Related PathwaysNLRP3 INFLAMMASOME

Wiki Pages (20)

Knowledge base pages for this entity

Novel Therapy Index

idea · 10647 words

calcium-dysregulation-comparison

mechanism · 6468 words

Therapeutics

index · 5665 words

Alzheimer's Disease

disease · 5265 words

p-tau-217

biomarker · 4980 words

Pathway Diagram

graph TD
    VASCULAR_DEMENTIA["VASCULAR DEMENTIA"]
    style VASCULAR_DEMENTIA fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    VASCULAR_DEMENTIA -->|"causes"| Cerebrovascular["Cerebrovascular"]
    VASCULAR_DEMENTIA -->|"activates"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Myelination["Myelination"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Apoptosis["Apoptosis"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Inflammasome["Inflammasome"]
    VASCULAR_DEMENTIA -->|"activates"| Dendritic_Spine["Dendritic Spine"]
    VASCULAR_DEMENTIA -->|"activates"| Camp_Signaling["Camp Signaling"]
    VASCULAR_DEMENTIA -.->|"inhibits"| Amyloid["Amyloid"]
    Chronic_Cerebral_Hypoperfusion["Chronic Cerebral Hypoperfusion"] -->|"causes"| VASCULAR_DEMENTIA
    FERROPTOSIS["FERROPTOSIS"] -->|"contributes to"| VASCULAR_DEMENTIA
    CHRONIC_CEREBRAL_HYPOPERFUSION["CHRONIC CEREBRAL HYPOPERFUSION"] -->|"causes"| VASCULAR_DEMENTIA
    Tong_Qiao_Huo_Xue_Decoction{"Tong-Qiao-Huo-Xue Decoction"} -->|"treats"| VASCULAR_DEMENTIA
    Cerebrovascular_Disease["Cerebrovascular Disease"] -->|"risk_factor_for"| VASCULAR_DEMENTIA
    NLRP3([NLRP3]) -->|"contributes to"| VASCULAR_DEMENTIA
    Ams_17["Ams-17"] -->|"treats"| VASCULAR_DEMENTIA
    AMS_17["AMS-17"] -->|"treats"| VASCULAR_DEMENTIA
    A3AR["A3AR"] -->|"treats"| VASCULAR_DEMENTIA

Outgoing (47)

TargetRelationTypeStr
ALZHEIMER'S DISEASEassociated_withentity0.85
APOEassociated_withgene0.50
APPassociated_withgene0.50
CREBassociated_withgene0.45
PREFRONTAL CORTEXassociated_withbrain_region0.45

Incoming (169)

SourceRelationTypeStr
FERROPTOSIScontributes_toentity0.95
CHRONIC CEREBRAL HYPOPERFUSIONcausesentity0.95
MMP9contributes_toprotein0.75
GLYCOLYSIScausesphenotype0.65
GLUTAMATEcausesphenotype0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What are the specific molecular mechanisms by which C1Q components drive atheros

neuroinflammation | 2026-04-07 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found