Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VASCULAR DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | VASCULAR DEMENTIA |
| Key Genes/Proteins | MMP9, APOE, APP, CREB |
| Related Diseases | GLYCOLYSIS, GLUTAMATE, NEUROINFLAMMATION |
| Related Pathways | NLRP3 INFLAMMASOME |
Knowledge base pages for this entity
graph TD
VASCULAR_DEMENTIA["VASCULAR DEMENTIA"]
style VASCULAR_DEMENTIA fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
VASCULAR_DEMENTIA -->|"causes"| Cerebrovascular["Cerebrovascular"]
VASCULAR_DEMENTIA -->|"activates"| Blood_Brain_Barrier["Blood-Brain Barrier"]
VASCULAR_DEMENTIA -.->|"inhibits"| Myelination["Myelination"]
VASCULAR_DEMENTIA -.->|"inhibits"| Apoptosis["Apoptosis"]
VASCULAR_DEMENTIA -.->|"inhibits"| Inflammasome["Inflammasome"]
VASCULAR_DEMENTIA -->|"activates"| Dendritic_Spine["Dendritic Spine"]
VASCULAR_DEMENTIA -->|"activates"| Camp_Signaling["Camp Signaling"]
VASCULAR_DEMENTIA -.->|"inhibits"| Amyloid["Amyloid"]
Chronic_Cerebral_Hypoperfusion["Chronic Cerebral Hypoperfusion"] -->|"causes"| VASCULAR_DEMENTIA
FERROPTOSIS["FERROPTOSIS"] -->|"contributes to"| VASCULAR_DEMENTIA
CHRONIC_CEREBRAL_HYPOPERFUSION["CHRONIC CEREBRAL HYPOPERFUSION"] -->|"causes"| VASCULAR_DEMENTIA
Tong_Qiao_Huo_Xue_Decoction{"Tong-Qiao-Huo-Xue Decoction"} -->|"treats"| VASCULAR_DEMENTIA
Cerebrovascular_Disease["Cerebrovascular Disease"] -->|"risk_factor_for"| VASCULAR_DEMENTIA
NLRP3([NLRP3]) -->|"contributes to"| VASCULAR_DEMENTIA
Ams_17["Ams-17"] -->|"treats"| VASCULAR_DEMENTIA
AMS_17["AMS-17"] -->|"treats"| VASCULAR_DEMENTIA
A3AR["A3AR"] -->|"treats"| VASCULAR_DEMENTIA| Target | Relation | Type | Str |
|---|---|---|---|
| ALZHEIMER'S DISEASE | associated_with | entity | 0.85 |
| APOE | associated_with | gene | 0.50 |
| APP | associated_with | gene | 0.50 |
| CREB | associated_with | gene | 0.45 |
| PREFRONTAL CORTEX | associated_with | brain_region | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FERROPTOSIS | contributes_to | entity | 0.95 |
| CHRONIC CEREBRAL HYPOPERFUSION | causes | entity | 0.95 |
| MMP9 | contributes_to | protein | 0.75 |
| GLYCOLYSIS | causes | phenotype | 0.65 |
| GLUTAMATE | causes | phenotype | 0.65 |
| NEUROINFLAMMATION | causes | phenotype | 0.65 |
| GLYCOLYSIS | expressed_in | phenotype | 0.55 |
| NEUROINFLAMMATION | implicated_in | phenotype | 0.55 |
| NLRP3 INFLAMMASOME | associated_with | pathway | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neuroinflammation | 2026-04-07 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||