pathway

Hippo Pathway

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Hippo Pathway: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

174Connections

0Hypotheses

0Analyses

4Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	Hippo Pathway
Key Genes/Proteins	HIPPO, CANCER, YAP, APOPTOSIS, PI3K, AKT
Related Diseases	Cancer, Als, Tumor

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HIPPO["HIPPO"] -->|"regulates"| Hippo_Pathway["Hippo Pathway"]
    CANCER["CANCER"] -->|"therapeutic target"| Hippo_Pathway["Hippo Pathway"]
    Cancer["Cancer"] -->|"therapeutic target"| Hippo_Pathway["Hippo Pathway"]
    HIPPO_1["HIPPO"] -->|"associated"| Hippo_Pathway["Hippo Pathway"]
    style Hippo_Pathway fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
Breast Cell Fate	regulates	process	0.90
CELL MIGRATION	activates	concept	0.50
Fibroblast	activates	cell_type	0.50
Neuron	regulates	cell_type	0.50

Incoming (159)

Source	Relation	Type	Str
HIPPO	regulates	gene	1.00
CANCER	therapeutic_target	gene	0.70
Cancer	therapeutic_target	disease	0.70
HIPPO	associated_with	gene	0.70
YAP	associated_with	gene	0.70
HIPPO	therapeutic_target	gene	0.70
Als	therapeutic_target	disease	0.70
CANCER	regulates	gene	0.70
Cancer	regulates	disease	0.70
APOPTOSIS	regulates	gene	0.70
PI3K	regulates	gene	0.70
AKT	regulates	gene	0.70
Tumor	activates	disease	0.65
DDB1	regulates	gene	0.60
LATS1	regulates	gene	0.60
TAZ	regulates	gene	0.60
YAP	regulates	gene	0.60
EGFR	activates	gene	0.60
LIF	activates	gene	0.60
HIPPO	interacts_with	gene	0.60
Tumor	therapeutic_target	disease	0.60
TAZ	associated_with	gene	0.60
KRAS	associated_with	gene	0.60
RAS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
Pancreatic Cancer	associated_with	disease	0.60
Cancer	associated_with	disease	0.60
Tumor	associated_with	disease	0.60
APOPTOSIS	implicated_in	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
NEURODEGENERATIVE DISEASES	implicated_in	gene	0.60
NEURODEGENERATIVE DISORDERS	implicated_in	gene	0.60
Tumor	implicated_in	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
MST1	therapeutic_target	gene	0.60
QKI	therapeutic_target	gene	0.60
NCL	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
KRAS	activates	gene	0.60
CANCER	implicated_in	gene	0.60
MYC	activates	gene	0.60
Cancer	implicated_in	disease	0.60
Carcinoma	activates	disease	0.60
Hepatocellular Carcinoma	activates	disease	0.60
MIRNAS	regulates	gene	0.60
OVERVIEW	regulates	gene	0.60
Als	associated_with	disease	0.60
ERK1	regulates	gene	0.60
Breast Cancer	regulates	disease	0.60
Als	regulates	disease	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Hippo Pathway

Understanding Entity Pages

Wiki Pages (20)

Corticobasal Syndrome (CBS)

Novel Therapy Index

TEAD1 — TEA Domain Transcription Factor 1

TAZ (WWTR1)

PDCD10 Gene (Programmed Cell Death 10)

RAN Gene

wnt-beta-catenin-signaling-pathway

YAP/TAZ Signaling Pathway in Neurodegeneration

SCRIB Gene

YAP/TAZ (Hippo) Signaling in Neurodegeneration

SLIT2 — Slit Guidance Ligand 2

PPM1A Protein

MITF Gene — Microphthalmia-Associated Transcription Factor

CCM2 Protein

Hippo Signaling Pathway in Neurodegeneration

PRKAA2 (AMPKα2) — AMP-Activated Protein Kinase Catalytic Subunit Alpha 2

FOXO1 Gene

Cell Migration