protein

RAB7A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB7A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

895Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

3Experiments

Summary

RAB7A is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with AD, ADH, ALS. Connected to 467 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	RAB7A
Full Name	RAB7A, Member RAS Oncogene Family
Chromosome	3q21
Protein Type	Signaling Protein
Target Class	Signaling Protein
Function	RAB7A encodes a small GTPase that regulates late endosomal trafficking and lysosomal function.
Mechanism of Action	RAB7A inhibitors or modulators would block or enhance GTPase-mediated late endosome and lysosome trafficking, disrupting autophagy flux and lysosomal degradation pathways. This can either impair pathogenic protein clearance (in certain cancers) or restore lysosomal function (in storage disorders and neurodegeneration).
Druggability	High (0.75)
Clinical Stage	Phase III
Pathways	Autophagy, LIPOPHAGY, Mitophagy, Mtor, Oxidative Stress
UniProt ID	A0A6Q8PGE6
Ensembl ID	ENSG00000175756
OMIM	602298
GeneCards	RAB7A
Human Protein Atlas	RAB7A
Associated Diseases	AD, ADH, ALS, AMI, Alzheimer
Known Drugs/Compounds	rapamycin, Lactate, Llome
Interactions	RILP, TBK1, ATG4B, ATG3, CAT, G3BP1
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Mitochondrial-Lysosomal Contact Site Engineering
KG Connections	885 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure Comparison — RAB7A Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

1VG8 — X-ray / Cryo-EM

🔮 AI Predicted Structure

A0A6Q8PGE6 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RAB7A["RAB7A GTPase"] -->|"Mediates"| Lipophagy["Lipophagy"]
    RAB7A -->|"Regulates"| EndoTraffic["Endosomal Trafficking"]
    RAB7A -->|"Controls"| LysoFusion["Lysosomal Fusion"]
    EndoTraffic -->|"Delivers to"| Lysosomes["Lysosomes"]
    LysoFusion -->|"Enables"| Degradation["Cargo Degradation"]
    Lipophagy -->|"Clears"| LipidDroplets["Lipid Droplets"]
    RAB7A -.Associated with.-> ALS["ALS"]
    RAB7A -.Associated with.-> MS["Multiple Sclerosis"]
    RAB7A -.Associated with.-> Cancer["Cancer"]
    RAB7A -->|"Activates"| Autophagy["Autophagosome Maturation"]
    Degradation -->|"Maintains"| Homeostasis["Cellular Homeostasis"]

Outgoing (543)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Mitophagosome Formation	involved_in	process	0.95
Mitophagosome Formation	regulates	process	0.95
Endosomal Retrograde Transport	regulates	process	0.95
Gdp/Gtp-Binding	involved_in	process	0.95
Exosome Biogenesis	regulates	process	0.90
Endocytic Membrane Traffic	regulates	process	0.90
Late Endosome-Lysosome Fusion	regulates	process	0.90
PINK1-Parkin-Mediated Mitophagy	involved_in	process	0.90
Lipophagy	mediates	process	0.90
autophagosome-lysosome fusion	promotes	process	0.90
lysosomal trafficking	regulates	process	0.90
Autophagosome-Lysosome Fusion	activates	process	0.90
Lysosomal Trafficking	regulates	process	0.90
Tumor-Derived Exosome	involved_in	cell_type	0.90
Autophagosome-Lysosome Fusion	promotes	process	0.90
Lysosomal Trafficking	promotes	process	0.90
Periodontitis	associated_with	disease	0.90
exosome biogenesis	facilitates	process	0.90
Pink1-Parkin-Mediated Mitophagy	contributes_to	process	0.90
autophagosome formation	promotes	process	0.90
Lactylation	involved_in	process	0.88
CI-M6PR Trafficking	regulates	process	0.85
Autophagosome-Lysosome Fusion	regulates	process	0.85
Damaged Mitochondria	targets	phenotype	0.85
Lipophagy	regulates	process	0.85
Tumor-Derived Exosome Biogenesis	regulates	process	0.85
Ubiquitination	inhibits	process	0.85
CI-M6PR	regulates	receptor	0.85
PINK1	interacts_with	protein	0.85
PARKIN	interacts_with	protein	0.85
Retromer Complex	interacts_with	protein	0.85
Hepatocellular Carcinoma metastasis	contributes_to	phenotype	0.83
Late Endosomal Tubulation	regulates	process	0.80
Endosome To Lysosome Transport	regulates	process	0.80
ATG9A-Bearing Vesicles	targets	process	0.80
Autolysosome Maturation	regulates	process	0.80
Lactate	associated_with	chemical	0.80
periodontitis	regulates	disease	0.80
Exosome Biogenesis	associated_with	biological_process	0.80
Periodontal Homeostasis	associated_with	phenotype	0.80
Tau Secretion	regulates	process	0.80
autolysosome maturation	promotes	process	0.80
tubulation	modulates	phenotype	0.80
CI-M6PR recycling	regulates	process	0.80
RAS	activates	gene	0.80
RAB7_protein	encodes	protein	0.80
Als	associated_with	disease	0.75
Cancer	activates	disease	0.75
Macrophage	expressed_in	cell_type	0.75

Incoming (352)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
Lactate	modulates	compound	0.95
RILP	interacts_with	protein	0.95
RILP	interacts_with	protein	0.95
Late Endosomal Ph Collapse	causes	process	0.95
ATP6V1G1	associated_with	gene	0.95
V-ATPase	activates	protein	0.90
Late Endosomal pH Neutralization	activates	process	0.90
SIRT5	mediates	gene	0.90
Llome	activates	compound	0.90
Ph Neutralization	activates	process	0.90
V-Atpase	modulates	enzyme	0.90
RILP	modulates	protein	0.90
h-0791836f	targets_gene	hypothesis	0.90
lactate accumulation	upregulates	process	0.87
RAB7A GEF	activates	protein	0.85
RAB7A GAP	associated_with	protein	0.85
Reduced Usp4	causes	phenotype	0.85
USP4	deubiquitinates	protein	0.85
h-0791836f	targets	hypothesis	0.80
RETROMER COMPLEX	interacts_with	protein	0.80
Exosome Biogenesis	associated_with	biological_process	0.80
SIRT5	associated_with	gene	0.80
ATG	activates	gene	0.80
rapamycin	targets	drug	0.80
USP4	depletion_impairs_ubiquitylation	gene	0.80
USP4	regulates	gene	0.80
SQSTM1	regulates	gene	0.70
LC3	regulates	gene	0.70
CANCER	activates	gene	0.70
ENDOSOME	regulates	gene	0.70
AUTOPHAGY	regulates	gene	0.70
ENDOSOME	associated_with	gene	0.65
ACTB	regulates	gene	0.60
PPARA	regulates	gene	0.60
CAT	regulates	gene	0.60
RPS6KB1	regulates	gene	0.60
GABARAP	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
RTN3	associated_with	gene	0.60
LAMP2	associated_with	gene	0.60
DNM1L	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RAB2A	associated_with	gene	0.60
VAMP7	associated_with	gene	0.60
STX17	associated_with	gene	0.60
IGF2R	associated_with	gene	0.60
PARKIN	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mitochondrial-Lysosomal Contact Site Engineering	0.430	neurodegeneration	Autophagy-lysosome pathway convergence a

Mentioning Analyses (1)

Scientific analyses that reference this entity

Autophagy-lysosome pathway convergence across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.665

Experiments (3)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
MLCS Quantification in Parkinson's Disease	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
Validate Mitochondria-Lysosome Contact Site Dysfunction in PD	validation	Parkinson's Disease	0.400	0.50	human	proposed	$2,730,000
TMEM106B Haplotype as Genetic Modifier in FTD — Mechanism and Therapeu	validation	Neurodegeneration	0.400	0.50	human	proposed	$2,730,000

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Lactate accumulation drives hepatocellular carcinoma metastasis through facilita [PMID:40120799]	Jiang C, He X, Chen X, Huang J, Liu Y, Z	Cancer Lett	2025	1
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signa [PMID:32972302]	Zhou C, Liang Y, Zhou L, Yan Y, Liu N, Z	Autophagy	2021	1
Role of the endolysosomal pathway and exosome release in tau propagation. [PMID:33582164]	Yan M, Zheng T	Neurochem Int	2021	1
Rab7a and Mitophagosome Formation. [PMID:30857122]	Tan EHN, Tang BL	Cells	2019	1
YY1 nitration participates in DbCM cardiomyocyte lipotoxicity by inhibiting ANXA [PMID:41702019]	Chai J, Han L, Mo D, Bai Y, Yang Y et al	Redox Biol	2026	0
Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078]	["Ranjitha V", "Kumar A", "Kaalappa P"]	Pharmaceutical research	2025	0
Activation of Lysosomal Retrograde Transport Triggers TPC1-IP3R1 Ca2+ Crosstalk [PMID:40709664]	Zhu MY, Guo YJ, Zhu YQ, Wang HZ, Wang HD	Advanced science (Weinheim, Ba	2025	0
Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746]	["Sanadgol N", "Abedi M", "Hashemzaei M"	Journal of nanobiotechnology	2025	0
ER membrane contact sites support endosomal small GTPase conversion for exosome [PMID:36136097]	Verweij FJ, Bebelman MP, George AE, Cout	The Journal of cell biology	2022	0
Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis thro [PMID:33927350]	["Liu L", "Zhang X", "Ding H", "Liu X",	Oncogene	2021	0
OxCOVID19 Database, a multimodal data repository for better understanding the gl [PMID:33927237]	["Mahdi A", "B\u0142aszczyk P", "D\u0142	Scientific reports	2021	0
Kidney enlargement effect of angioplasty for nonatherosclerotic renovascular dis [PMID:32444857]	["Iwasaki T", "Mishima E", "Suzuki T", "	Hypertension research : offici	2020	0
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell [PMID:29674595]	["Filbin M", "Tirosh I", "Hovestadt V",	Science (New York, N.Y.)	2018	0
Aloperine Protects Mice against Bleomycin-induced Pulmonary Fibrosis by Attenuat [PMID:29674691]	["Yin W", "Han J", "Zhang Z", "Han Z", "	Scientific reports	2018	0
THz Electric Field-Induced Second Harmonic Generation in Inorganic Ferroelectric [PMID:28386081]	["Grishunin K", "Ilyin N", "Sherstyuk N"	Scientific reports	2017	0

RAB7A

Understanding Entity Pages

Summary

Wiki Pages (21)

RAB7A — RAB7A, Member RAS Oncogene Family

Autophagy Mechanisms

autophagy-lysosomal-alzheimers

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

Autophagy-Lysosomal Pathway in Parkinson's Disease

autophagy-lysosome-dysfunction

Sandhoff Disease

Retromer Dysfunction in Neurodegeneration

RAB35 — Ras-Associated Protein 35

Mitochondria-Lysosome Contact Sites (MLCS) in Neurodegeneration

Mitochondria-Lysosome Contact Site (MLCS) Dysfunction Hypothesis in Parkinson's Disease

RABEP1

Autophagy Types in Neurodegeneration

autophagy-lysosomal-ad

autophagy

Autophagy-Impaired Neurons

Autophagy-Lysosome Pathway in Neurodegeneration

Validate Mitochondria-Lysosome Contact Site Dysfunction in PD

CTNNB1 — Catenin Beta 1

Targeted Protein Degradation (PROTACs)

Section 253: Respiratory Function and Dysphagia Therapy in CBS/PSP