concept

PSMD14

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMD14: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

42Outgoing

30Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PSMD14
Key Genes/Proteins	PINK1, PKM2, PSMB1, FN1, SNCA, EGFR
Related Diseases	traumatic brain injury, Prion, Huntington, Alzheimer, Parkinson

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PSMD14["PSMD14"]
    PSMD14 -->|"inhibits"| PANoptosis["PANoptosis"]
    PSMD14 -->|"activates"| PINK1["PINK1"]
    PSMD14 -->|"deubiquitinating"| PKM2["PKM2"]
    PSMD14 -->|"target for"| traumatic_brain_injury["traumatic brain injury"]
    PSMD14 -->|"target for"| Prion["Prion"]
    PSMD14 -->|"target for"| Huntington["Huntington"]
    PSMD14 -->|"target for"| Alzheimer["Alzheimer"]
    PSMD14 -->|"target for"| Parkinson["Parkinson"]
    lactate["lactate"] -->|"upregulates"| PSMD14
    PARKINSON["PARKINSON"] -->|"target for"| PSMD14
    SOX2["SOX2"] -->|"interacts"| PSMD14
    SNAP25["SNAP25"] -->|"interacts"| PSMD14
    SOD1["SOD1"] -->|"interacts"| PSMD14
    CCT2["CCT2"] -->|"interacts"| PSMD14
    GAPDH["GAPDH"] -->|"interacts"| PSMD14
    HUNTINGTON["HUNTINGTON"] -->|"target for"| PSMD14

Outgoing (42)

Target	Relation	Type	Str
PANoptosis	inhibits	process	0.95
PINK1	activates	protein	0.90
PKM2	deubiquitinating	protein	0.90
traumatic brain injury	therapeutic_target	disease	0.90
Prion	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
FN1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
PSMA3	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
GRIA1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
ACTG1	interacts_with	gene	0.60
YWHAZ	interacts_with	gene	0.60
Blood-Brain Barrier	therapeutic_target	pathway	0.60
Mapk	interacts_with	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
PTEN	activates	gene	0.60
RIPK1	activates	gene	0.60
RIPK3	activates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
traumatic brain injury	associated_with	disease	0.60
ROS	activates	gene	0.60
traumatic brain injury	activates	disease	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
SNAP25	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
SOX2	interacts_with	gene	0.60
MAPK signaling	participates_in	pathway	0.60
epigenetic regulation	participates_in	pathway	0.55
unfolded protein response	participates_in	pathway	0.55
autophagy pathway	participates_in	pathway	0.55
astrocytes	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55

Incoming (30)

Source	Relation	Type	Str
lactate	upregulates	drug	0.85
PSMB1	associated_with	gene	0.80
PARKINSON	therapeutic_target	gene	0.60
SOX2	interacts_with	gene	0.60
SNAP25	interacts_with	gene	0.60
SOD1	interacts_with	gene	0.60
CCT2	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
GFAP	interacts_with	gene	0.60
CDC42	interacts_with	gene	0.60
HSP90AB1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PINK1	activates	gene	0.60
PKM	activates	gene	0.60
PKM2	activates	gene	0.60
MLKL	activates	gene	0.60
PI3K	activates	gene	0.60
ACTG1	interacts_with	gene	0.60
ATP5A1	interacts_with	gene	0.60
EGFR	interacts_with	gene	0.60
FN1	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
MAPK1	interacts_with	gene	0.60
PSMA3	interacts_with	gene	0.60
ATG5	activates	gene	0.55
ATG7	activates	gene	0.55
HDAC	activates	gene	0.55
LAMP1	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PSMD14

Understanding Entity Pages

Wiki Pages (4)

Proteasomal Pathway in Neurodegeneration

26S Proteasome