concept

B CELL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about B CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

477Connections

1Hypotheses

1Analyses

43Outgoing

5Incoming

Summary

B CELL is a concept in neurodegeneration research. Key relationships include: co discussed, activates, inhibits. Associated with GLIOBLASTOMA, LYMPHOMA, TUMOR. Connected to 30 entities in the SciDEX knowledge graph.

View on Wiki →

💡 Concept Info

Name	B CELL
Key Genes/Proteins	P53, BCL2, IL-6, AMPK, STING, MYC
Related Diseases	CANCER, LYMPHOMA
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    B_CELL["B CELL"]
    TCR["TCR"] -->|"expressed in"| B_CELL
    CD40["CD40"] -->|"expressed in"| B_CELL
    CANCER["CANCER"] -->|"expressed in"| B_CELL
    AQP4["AQP4"] -->|"expressed in"| B_CELL
    COMPLEMENT["COMPLEMENT"] -->|"expressed in"| B_CELL
    ASTROCYTES["ASTROCYTES"] -->|"expressed in"| B_CELL
    CD19["CD19"] -->|"expressed in"| B_CELL
    ASTROCYTE["ASTROCYTE"] -->|"expressed in"| B_CELL
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"expressed in"| B_CELL
    AQUAPORIN_4["AQUAPORIN-4"] -->|"expressed in"| B_CELL

Outgoing (74)

Target	Relation	Type	Str
NEUROMYELITIS OPTICA SPECTRUM DISORDER	involved_in	entity	0.90
NEUTROPHIL	increases	cell_type	0.65
CANCER	inhibits	disease	0.65
P53	inhibits	gene	0.65
BCL2	regulates	gene	0.65
LYMPHOMA	causes	disease	0.65
IL-6	inhibits	gene	0.65
LYMPHOMA	reduces	disease	0.65
T CELL	activates	cell_type	0.60
T CELLS	activates	cell_type	0.60
STING	causes	gene	0.60
MYC	activates	gene	0.60
LYMPHOMA	inhibits	disease	0.60
GFAP	activates	gene	0.60
MACROPHAGE	regulates	cell_type	0.60
MACROPHAGES	regulates	cell_type	0.60
MONOCYTE	promotes	cell_type	0.60
MONOCYTES	promotes	cell_type	0.60
TUMOR	inhibits	disease	0.60
CHAT	activates	gene	0.60
NEURON	activates	cell_type	0.60
NEURONS	activates	cell_type	0.60
T CELL	co_discussed	entity	0.50
T CELLS	co_discussed	entity	0.50
COMPLEMENT	co_discussed	entity	0.50
STING	co_discussed	entity	0.50
OCLN	co_discussed	entity	0.50
ENDOTHELIAL	co_discussed	entity	0.50
PERICYTE	co_discussed	entity	0.50
PERICYTES	co_discussed	entity	0.50
GFAP	co_discussed	entity	0.50
MACROPHAGE	co_discussed	entity	0.50
LYMPHOMA	co_discussed	disease	0.40
DENDRITIC CELL	co_discussed	cell_type	0.40
GLIOBLASTOMA	co_discussed	disease	0.40
RAGE	co_discussed	gene	0.40
TUMOR	co_discussed	disease	0.40
CANCER	co_discussed	disease	0.40
MACROPHAGES	co_discussed	cell_type	0.40
NEUTROPHIL	co_discussed	cell_type	0.40
BCL2	co_discussed	gene	0.40
MONOCYTE	co_discussed	cell_type	0.40
MONOCYTES	co_discussed	cell_type	0.40

Incoming (403)

Source	Relation	Type	Str
AMPK	activates	gene	0.65
AQP4	activates	gene	0.60
AQP4	inhibits	gene	0.60
AQP4	co_discussed	entity	0.50
APOPTOSIS	co_discussed	entity	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ	0.612	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.612

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

B CELL

Understanding Entity Pages

Summary

Wiki Pages (20)

neuroinflammation

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Autophagy Mechanisms

Oligodendrocytes

LRRK2 Pathway in Parkinson's Disease

NACET (N-Acetylcysteine Ethyl Ester)

Multiple Sclerosis (MS)

Cleveland Clinic Lerner Research Institute

NF-kB Signaling Pathway in Neurodegeneration

Neurogenesis

Exosome and Extracellular Vesicle Brain Delivery

Neuroinflammation Across AD, PD, ALS, FTD, and HD

cynata-therapeutics

Meningeal Lymphatics

RASGRP1 Gene

Endocannabinoid System Dysfunction Hypothesis in Parkinson's Disease

Neuroinflammation in Amyotrophic Lateral Sclerosis

Blood-Brain Barrier Breakdown in Neurodegeneration

CR1 Gene — Complement Component 1q Receptor