pathway

P53 Pathway

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about P53 Pathway: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

0Hypotheses

0Analyses

1Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	P53 Pathway
Key Genes/Proteins	ALZHEIMER'S DISEASE, AND, APP/PS1, APP, NEURODEGENERATIVE DISEASES, AGING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| P53_Pathway["P53 Pathway"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    AND["AND"] -->|"activates"| P53_Pathway["P53 Pathway"]
    style AND fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APP_PS1["APP/PS1"] -->|"activates"| P53_Pathway["P53 Pathway"]
    style APP_PS1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    APP["APP"] -->|"activates"| P53_Pathway["P53 Pathway"]
    style APP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"activates"| P53_Pathway["P53 Pathway"]
    style NEURODEGENERATIVE_DISEASES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style P53_Pathway fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (11)

Target	Relation	Type	Str
Proteins	associated_with	protein	0.50

Incoming (79)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	activates	gene	0.60
AND	activates	gene	0.60
APP/PS1	activates	gene	0.60
APP	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
AGING	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
ROS	activates	gene	0.60
DEMENTIA	activates	gene	0.60
P53	activates	gene	0.60
IL1B	expressed_in	gene	0.60
CD14	activates	gene	0.60
TNF	expressed_in	gene	0.60
TREM2	expressed_in	gene	0.60
ICAM1	activates	gene	0.60
GENES	expressed_in	gene	0.60
ITGAM	activates	gene	0.60
JUN	activates	gene	0.60
NF-ΚB	expressed_in	gene	0.60
TLR2	activates	gene	0.60
CXCL2	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
MSR1	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
NFKBIA	activates	gene	0.60
CANCER	activates	gene	0.60
TNF-Α	expressed_in	gene	0.60
MRC1	expressed_in	gene	0.60
PPARG	expressed_in	gene	0.60
TP53	inhibits	gene	0.60
AND	inhibits	gene	0.60
AKT1	therapeutic_target	gene	0.60
GENES	therapeutic_target	gene	0.60
RAGE	therapeutic_target	gene	0.60
AKT	inhibits	gene	0.60
TNF-Α	therapeutic_target	gene	0.60
MYELIN	therapeutic_target	gene	0.60
IL-6	therapeutic_target	gene	0.60
TNF	therapeutic_target	gene	0.60
ALS	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
NEURODEGENERATION	protects_against	gene	0.60
C9ORF72	activates	gene	0.60
STAU1	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	protects_against	gene	0.60
DNA	protects_against	gene	0.60
DEMENTIA	protects_against	gene	0.60
P53	inhibits	gene	0.60
AUTOPHAGY	protects_against	gene	0.60
Alzheimer	activates	disease	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

P53 Pathway

Understanding Entity Pages

Wiki Pages (20)

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RAN Gene

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