concept

CHAPERONE-MEDIATED AUTOPHAGY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHAPERONE-MEDIATED AUTOPHAGY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections

0Hypotheses

0Analyses

27Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CHAPERONE-MEDIATED AUTOPHAGY
Key Genes/Proteins	Proteins, TFEB, NDP52, FIP200, SNAP29, WIPI2
Related Pathways	Chaperone

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CHAPERONE_MEDIATED_AUTOPHAGY["CHAPERONE-MEDIATED AUTOPHAGY"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"inhibits"| GPX4["GPX4"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"interacts"| Macroautophagy["Macroautophagy"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"regulates"| __synuclein_clearance["alpha-synuclein clearance"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"activates"| PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"activates"| UBIQUITIN["UBIQUITIN"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"activates"| LYSOSOME["LYSOSOME"]
    CHAPERONE_MEDIATED_AUTOPHAGY -->|"activates"| SQSTM1["SQSTM1"]
    LAMP2A["LAMP2A"] -->|"regulates"| CHAPERONE_MEDIATED_AUTOPHAGY
    LAMP2["LAMP2"] -->|"regulates"| CHAPERONE_MEDIATED_AUTOPHAGY
    AUTOPHAGY["AUTOPHAGY"] -->|"regulates"| CHAPERONE_MEDIATED_AUTOPHAGY
    CELL_CYCLE["CELL CYCLE"] -->|"activates"| CHAPERONE_MEDIATED_AUTOPHAGY
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CHAPERONE_MEDIATED_AUTOPHAGY
    BECN1["BECN1"] -->|"activates"| CHAPERONE_MEDIATED_AUTOPHAGY

Outgoing (37)

Target	Relation	Type	Str
PARKINSON'S DISEASE	activates	disease	0.35
UBIQUITIN	activates	gene	0.35
RAPAMYCIN	activates	drug	0.35
SQSTM1	activates	gene	0.35
SIRT1	activates	gene	0.35
GAPDH	activates	gene	0.35
MTOR	activates	gene	0.35
TP53	activates	gene	0.35
TFEB	activates	gene	0.35
ULK1	activates	gene	0.35
OPTN	activates	gene	0.35
CREB	activates	gene	0.35
P62	activates	gene	0.35
LC3	activates	gene	0.35
P53	activates	gene	0.35
RB1	activates	gene	0.35
MITOPHAGY	regulates	process	0.35
P62	regulates	gene	0.35
ROS	regulates	protein	0.35
FERROPTOSIS	activates	process	0.35
NEURON	activates	cell_type	0.35
GPX4	activates	gene	0.35
UBIQUITIN-PROTEASOME	regulates	process	0.35
DOPAMINERGIC NEURONS	interacts_with	cell_type	0.35
NEURON	interacts_with	cell_type	0.35
LAMP2	interacts_with	gene	0.35
DOPAMINERGIC NEURONS	regulates	cell_type	0.35

Incoming (82)

Source	Relation	Type	Str
AUTOPHAGY	regulates	process	0.65
Autophagy	interacts_with	process	0.50
Chaperone	interacts_with	pathway	0.50
Proteins	interacts_with	protein	0.50
TFEB	activates	protein	0.50
Autophagy	activates	process	0.50
ULK1	activates	gene	0.50
OPTN	activates	gene	0.50
NDP52	activates	gene	0.50
FIP200	activates	gene	0.50
SQSTM1	activates	gene	0.50
SNAP29	activates	gene	0.50
mTOR	activates	entity	0.50
WIPI2	activates	gene	0.50
PIK3C3	activates	gene	0.50
KAT8	activates	gene	0.50
GAPDH	activates	gene	0.50
TP53	activates	gene	0.50
SIRT1	activates	gene	0.50
RUBCN	activates	gene	0.50
HDAC6	activates	gene	0.50
CREBBP	activates	gene	0.50
EP300	activates	gene	0.50
LAMP2A	activates	gene	0.50
RB1CC1	activates	gene	0.50
KAT2A	activates	gene	0.50
KAT5	activates	gene	0.50
STX17	activates	gene	0.50
VAMP8	activates	gene	0.50
HSPA8	activates	gene	0.50
CALCOCO2	activates	gene	0.50
NBR1	activates	gene	0.50
CREB	activates	protein	0.50
SNARE	activates	protein	0.50
OPTINEURIN	activates	protein	0.50
RUBICON	activates	protein	0.50
HSP70	activates	protein	0.50
UBIQUITIN	activates	protein	0.50
TUMOR PROTEIN P53	activates	protein	0.50
HSC70	activates	protein	0.50
PKM2	activates	protein	0.50
VPS34	activates	protein	0.50
KAT2B	activates	gene	0.50
TUMOR	activates	disease	0.50
PARKINSON	activates	gene	0.50
apoptosis	activates	process	0.50
MAP1LC3	activates	gene	0.50
ACETYL-COA	activates	concept	0.50
ACAT1	activates	concept	0.50
Chaperone	activates	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHAPERONE-MEDIATED AUTOPHAGY

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Alpha-Synuclein Pathology

CBS/PSP Treatment Rankings

Synucleinopathy Mechanism

Autophagy Mechanisms

APOC4 — Apolipoprotein C-IV

psp-tauopathy

Neuroprotection Strategies in Neurodegeneration

proteasome-ubiquitin-system-dysfunction-parkinsons

GBA1→GCase→Lysosome→PD Causal Chain

Synuclein Pathway in Parkinson's Disease

ATP13A2 Lysosomal Dysfunction Pathway in Parkinson's Disease

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathies Causal Chain

Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD