concept

TNF SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNF SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

0Hypotheses

0Analyses

21Outgoing

23Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	TNF SIGNALING
Key Genes/Proteins	IL6, MMP9, TNF, AKT1, IL1B, MAPK14
Related Diseases	ALZHEIMER'S DISEASE

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TNF_SIGNALING["TNF SIGNALING"]
    VEGFA["VEGFA"] -->|"target for"| TNF_SIGNALING
    TNF__["TNF-Alpha"] -->|"target for"| TNF_SIGNALING
    Tumor["Tumor"] -->|"target for"| TNF_SIGNALING
    TNF["TNF"] -->|"inhibits"| TNF_SIGNALING
    INFLAMMATION["INFLAMMATION"] -->|"activates"| TNF_SIGNALING
    Inflammation["Inflammation"] -->|"activates"| TNF_SIGNALING
    AKT1["AKT1"] -->|"target for"| TNF_SIGNALING
    IL6["IL6"] -->|"target for"| TNF_SIGNALING
    EGF["EGF"] -->|"target for"| TNF_SIGNALING

Outgoing (22)

Target	Relation	Type	Str
IL6	targets	gene	0.65
MMP9	targets	gene	0.65
IL-17	regulates	concept	0.50
MAPK SIGNALING	regulates	concept	0.50
IL-17	expressed_in	concept	0.50
RIPK1	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
CASP3	associated_with	gene	0.45
PI3K	associated_with	gene	0.45
MAPK	associated_with	gene	0.45
IL1B	associated_with	gene	0.45
AKT	associated_with	gene	0.45
IL6	associated_with	gene	0.45
INFLAMMATION	associated_with	phenotype	0.45
MMP9	associated_with	gene	0.45
MICROGLIA	associated_with	cell_type	0.45
TNF	associated_with	gene	0.45
CXCL10	associated_with	gene	0.45
PARP1	associated_with	gene	0.45
CTSD	associated_with	gene	0.45
STROKE	associated_with	disease	0.45

Incoming (68)

Source	Relation	Type	Str
ALZHEIMER'S DISEASE	activates	disease	0.65
TNF	transports	gene	0.65
AKT1	expressed_in	gene	0.50
IL1B	expressed_in	gene	0.50
MMP9	expressed_in	gene	0.50
MAPK14	expressed_in	gene	0.50
TNF-α	expressed_in	concept	0.50
RIPK1	interacts_with	gene	0.50
TNFRSF1A	interacts_with	gene	0.50
TNFR1	interacts_with	protein	0.50
Pi3K	regulates	pathway	0.50
AKT1	regulates	gene	0.50
IL1B	regulates	gene	0.50
MAPK1	regulates	gene	0.50
CASP3	regulates	gene	0.50
apoptosis	regulates	process	0.50
MAPK	regulates	gene	0.50
Toll-Like Receptor	regulates	pathway	0.50
disease	inhibits	disease	0.50
NEURODEGENERATIVE DISEASE	inhibits	concept	0.50
inflammation	expressed_in	pathway	0.50
ALZHEIMER'S DISEASE	associated_with	disease	0.45
NEURODEGENERATION	associated_with	disease	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TNF SIGNALING

Understanding Entity Pages

Wiki Pages (20)

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

IL32

TNF Signaling Pathway in Neurodegeneration

Inflammaging in Neurodegeneration

LTBR Gene

JAK-STAT and Cytokine Signaling in 4R-Tauopathies

Necroptosis Pathway in Neurodegeneration

TNFAIP3 — TNF Alpha Induced Protein 3 (A20)

TNF Gene

Necroptosis in Neurodegeneration

TNFRSF1A Gene

Progranulin Therapy for Neurodegeneration

RIPK1 Inhibitor Therapy

RIPK1 Gene

Multiple Sclerosis Mechanistic Pathway

IL-1 Signaling Pathway in Neurodegeneration