Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CARCINOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | NF-KB, RAB7A, SLC7A11, OCLN, LRP1, FERMT2, ALZHEIMER |
| KG Connections | 187 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
CARCINOMA["CARCINOMA"] -->|"targets"| TUMOR["TUMOR"]
style TUMOR fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
CARCINOMA["CARCINOMA"] -.->|"inhibits"| IL_6["IL-6"]
style IL_6 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
CARCINOMA["CARCINOMA"] -->|"interacts"| GSK3B["GSK3B"]
style GSK3B fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
CARCINOMA["CARCINOMA"] -->|"interacts"| LAMP1["LAMP1"]
style LAMP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
CARCINOMA["CARCINOMA"] -->|"interacts"| LC3["LC3"]
style LC3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
CARCINOMA["CARCINOMA"] -->|"targets"| MTOR["MTOR"]
style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
CARCINOMA["CARCINOMA"] -->|"targets"| MYC["MYC"]
style MYC fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
AUTOPHAGY["AUTOPHAGY"] -->|"targets"| CARCINOMA["CARCINOMA"]
style AUTOPHAGY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
CANCER["CANCER"] -->|"targets"| CARCINOMA["CARCINOMA"]
style CANCER fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
BECN1["BECN1"] -->|"interacts"| CARCINOMA["CARCINOMA"]
style BECN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
AGING["AGING"] -->|"co discussed"| CARCINOMA["CARCINOMA"]
style AGING fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
GLYCOLYSIS["GLYCOLYSIS"] -.->|"inhibits"| CARCINOMA["CARCINOMA"]
style GLYCOLYSIS fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
style CARCINOMA fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Glycolysis | activates | pathway | 1.00 |
| Apoptosis | inhibits | pathway | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Ferroptosis | activates | pathway | 1.00 |
| Mtor | activates | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Hepatitis | associated_with | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Inflammation | associated_with | disease | 1.00 |
| Autophagy | therapeutic_target | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Drug Resistance | therapeutic_target | pathway | 1.00 |
| Metastasis | activates | pathway | 1.00 |
| Metastasis | therapeutic_target | pathway | 1.00 |
| Invasion | therapeutic_target | pathway | 1.00 |
| Tumor Microenvironment | therapeutic_target | pathway | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Hepatocellular Carcinoma | associated_with | disease | 1.00 |
| Metastasis | associated_with | pathway | 1.00 |
| Hepatocellular Carcinoma | activates | disease | 1.00 |
| Invasion | activates | pathway | 1.00 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 1.00 |
| Tumor Microenvironment | activates | pathway | 1.00 |
| Wnt | therapeutic_target | pathway | 1.00 |
| Autophagy | associated_with | pathway | 1.00 |
| Wnt | activates | pathway | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Pi3K/Akt | therapeutic_target | pathway | 1.00 |
| Mapk | therapeutic_target | pathway | 1.00 |
| Immune Checkpoint | inhibits | pathway | 1.00 |
| Lung Cancer | therapeutic_target | disease | 0.95 |
| Lung Cancer | associated_with | disease | 0.95 |
| Glycolysis | therapeutic_target | pathway | 0.90 |
| Oxidative Stress | therapeutic_target | pathway | 0.90 |
| Immune Response | activates | pathway | 0.90 |
| Oxidative Stress | activates | pathway | 0.90 |
| Tgf-Β | activates | pathway | 0.90 |
| Autophagy | regulates | pathway | 0.90 |
| Mapk | inhibits | pathway | 0.90 |
| Lipid Metabolism | therapeutic_target | pathway | 0.90 |
| Glycolysis | regulates | pathway | 0.90 |
| Invasion | treats | pathway | 0.90 |
| Mtor | treats | pathway | 0.90 |
| Nf-Κb | therapeutic_target | pathway | 0.90 |
| Autophagy | implicated_in | pathway | 0.90 |
| Epithelial-Mesenchymal Transition | activates | pathway | 0.90 |
| Invasion | expressed_in | pathway | 0.90 |
| Source | Relation | Type | Str |
|---|---|---|---|
| STAT3 | activates | gene | 1.00 |
| EGFR | activates | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| P62 | activates | gene | 1.00 |
| GENES | expressed_in | gene | 1.00 |
| DNA | associated_with | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| TP53 | associated_with | gene | 1.00 |
| NRF2 | activates | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| STING | activates | gene | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| MYC | activates | gene | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| ERK | activates | gene | 1.00 |
| KRAS | activates | gene | 1.00 |
| GENES | associated_with | entity | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| CANCER | expressed_in | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| FERROPTOSIS | activates | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| AUTOPHAGY | associated_with | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| PTEN | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| CYTOKINES | activates | gene | 1.00 |
| UBIQUITIN | activates | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| BCL-2 | therapeutic_target | gene | 1.00 |
| CANCER | causes | gene | 1.00 |
| RAS | activates | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| CANCER | implicated_in | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity