Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about nitric oxide: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| endothelial cells | released_by | cell_type | 0.90 |
| astrocytes | released_by | cell_type | 0.70 |
| macrophages | released_by | cell_type | 0.70 |
| neural stem cells | released_by | cell_type | 0.60 |
| microglia | released_by | cell_type | 0.60 |
| blood-brain barrier | active_in | brain_region | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SODs | protects_against | protein | 0.80 |
| CREB | activates | gene | 0.70 |
| ROS | activates | gene | 0.70 |
| VEGF | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| VEGF | interacts_with | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| KCNK2 | expressed_in | gene | 0.60 |
| GLP1R | activates | gene | 0.60 |
| SIRT1 | activates | gene | 0.60 |
| TP53 | activates | gene | 0.60 |
| SREBF2 | activates | gene | 0.60 |
| STX17 | activates | gene | 0.60 |
| STING1 | activates | gene | 0.60 |
| TFEB | activates | gene | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| SIRT3 | activates | gene | 0.60 |
| ULK1 | activates | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| PLIN2 | activates | gene | 0.60 |
| LAMP2 | activates | gene | 0.60 |
| NFE2L2 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| C1Q | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| LC3 | activates | gene | 0.60 |
| GLP1R | regulates | gene | 0.60 |
| SIRT1 | regulates | gene | 0.60 |
| TP53 | regulates | gene | 0.60 |
| SREBF2 | regulates | gene | 0.60 |
| STX17 | regulates | gene | 0.60 |
| STING1 | regulates | gene | 0.60 |
| TFEB | regulates | gene | 0.60 |
| FOXO1 | regulates | gene | 0.60 |
| SIRT3 | regulates | gene | 0.60 |
| ULK1 | regulates | gene | 0.60 |
| BECN1 | regulates | gene | 0.60 |
| PLIN2 | regulates | gene | 0.60 |
| LAMP2 | regulates | gene | 0.60 |
| NFE2L2 | regulates | gene | 0.60 |
| MTOR | regulates | gene | 0.60 |
| C1Q | regulates | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| LC3 | regulates | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| migraine | disrupts | disease | 0.60 |
| neurodegeneration | disrupts | disease | 0.60 |
| obesity | disrupts | disease | 0.60 |
| TNF | treats | gene | 0.60 |
| ANXA1 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||