concept

ALOX12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ALOX12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

287Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

ALOX12 is a concept in neurodegeneration research. Key relationships include: activates, inhibits, contributes to. Associated with ALS, Als, Anxiety. Connected to 95 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	ALOX12
Key Genes/Proteins	TP53, NAT10, P53
Related Diseases	Hepatic Ischemia-Reperfusion Injury

🔮 Predicted Structure: ALOX12 — AlphaFold P18054 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ALOX12["ALOX12"]
    ALOX12 -->|"activates"| Cancer["Cancer"]
    ALOX12 -->|"inhibits"| Als["Als"]
    ALOX12 -->|"activates"| Ischemia["Ischemia"]
    ALOX12 -->|"inhibits"| Inflammation["Inflammation"]
    ALOX12 -->|"inhibits"| ALS["ALS"]
    ALOX12 -->|"co_expressed_with"| ALOX5["ALOX5"]
    SBFI26["SBFI26"] -->|"upregulates"| ALOX12
    h_83efeed6["h-83efeed6"] -->|"targets"| ALOX12
    ACSL4["ACSL4"] -->|"inhibits"| ALOX12
    JUN["JUN"] -->|"inhibits"| ALOX12
    ALOX5 -->|"contributes to"| ALOX12
    HMOX1["HMOX1"] -->|"activates"| ALOX12
    ALOX15["ALOX15"] -->|"activates"| ALOX12
    GPX4["GPX4"] -->|"inhibits"| ALOX12
    GENES["GENES"] -->|"contributes to"| ALOX12

Outgoing (211)

Target	Relation	Type	Str
Hepatic Ischemia-Reperfusion Injury	mediates	disease	0.95
tumour suppression	involved_in	process	0.95
Lipoxygenases	associated_with	enzyme	0.90
p53-mediated tumour suppression	required_for	process	0.90
tumorigenesis	suppresses	process	0.90
12-Hete	upregulates	compound	0.90
TP53	mediates	entity	0.85
Hepatocytes	expressed_in	cell_type	0.85
polyunsaturated fatty acids	interacts_with	compound	0.85
cancer	risk_factor_for	disease	0.85
Ferroptosis	promotes	process	0.85
Inflammation	promotes	process	0.85
lipoxygenase	associated_with	enzyme	0.80
reactive oxygen species stress	modulates	process	0.80
12-lipoxygenase	encodes	protein	0.80
Ferroptosis	activates	pathway	0.80
Neurodegeneration	activates	disease	0.75
ferroptosis	participates_in	pathway	0.70
ferroptosis	activates	process	0.70
SLC7A11	activates	gene	0.70
GSH	expressed_in	gene	0.70
endothelial cells	inhibits	cell_type	0.70
ALOX5	co_expressed_with	gene	0.65
Cancer	activates	disease	0.65
Lymphoma	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	inhibits	disease	0.65
Ischemia	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Als	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Als	associated_with	disease	0.65
ALS	inhibits	disease	0.65
ALS	interacts_with	disease	0.65
Anxiety	activates	disease	0.65
Parkinson	activates	disease	0.65
GPX4	co_mentioned_with	gene	0.60
ALOX15	co_mentioned_with	gene	0.60
GPX4	activates	entity	0.60
ALOX15	associated_with	entity	0.60
ALOX5	associated_with	entity	0.60
GPX4	inhibits	gene	0.60
ALOX15	contributes_to	gene	0.60
NFE2L2	activates	gene	0.60
FER	activates	gene	0.60
MYC	associated_with	gene	0.60
ALOX5	contributes_to	gene	0.60
ALOX5	activates	gene	0.60
ALOX15	activates	gene	0.60

Incoming (76)

Source	Relation	Type	Str
TP53	regulates	gene	0.90
NAT10	upregulates	protein	0.90
Luteolin	targets	compound	0.90
P53	requires	protein	0.90
Ischemia	upregulates	process	0.90
h-83efeed6	targets_gene	hypothesis	0.90
Luteolin	downregulates	compound	0.85
SBFI26	upregulates	drug	0.85
h-83efeed6	targets	hypothesis	0.80
ALOX15	activates	gene	0.70
SLC7A11	activates	gene	0.70
ALOX15	associated_with	gene	0.70
NEURODEGENERATION	activates	gene	0.70
P53	activates	gene	0.70
FERROPTOSIS	activates	gene	0.70
ACSL4	activates	entity	0.60
MYC	associated_with	gene	0.60
ACSL4	inhibits	gene	0.60
JUN	inhibits	gene	0.60
ALOX5	contributes_to	gene	0.60
ALOX5	activates	gene	0.60
HMOX1	activates	gene	0.60
GPX4	inhibits	gene	0.60
ALOX15	contributes_to	gene	0.60
FER	activates	gene	0.60
NFE2L2	activates	gene	0.60
GPX4	activates	gene	0.60
IREB2	activates	gene	0.60
TP53	activates	gene	0.60
NOX4	activates	gene	0.60
JNK	activates	gene	0.60
P38	activates	gene	0.60
TFR1	activates	gene	0.60
ACSL4	regulates	gene	0.60
ACSL4	expressed_in	gene	0.60
GENES	contributes_to	gene	0.60
ALOX	contributes_to	gene	0.60
GENES	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
ANXIETY	activates	gene	0.60
PARKINSON	activates	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AND	activates	gene	0.60
ALOX12B	contributes_to	gene	0.60
ALOXE3	contributes_to	gene	0.60
CANCER	activates	gene	0.60
ALOXE3	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Circadian-Gated Maresin Biosynthesis Amplification	0.471	neurodegeneration	Neuroinflammation resolution mechanisms

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation resolution mechanisms and pro-resolving mediators

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.552

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134]	Yang J, Borchert A, Kuhn H	J Biol Chem	2026	1
SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826]	He G, Zhang Y, Feng Y, Chen T, Liu M, Ze	J Cell Mol Med	2024	1
ALOX12 is required for p53-mediated tumour suppression through a distinct ferrop [PMID:30962574]	Chu B, Kon N, Chen D, Li T, Liu T, Jiang	Nat Cell Biol	2019	1
Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies. [PMID:30472260]	Singh NK, Rao GN	Prog Lipid Res	2019	1
An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-rep [PMID:29227475]	Zhang XJ, Cheng X, Yan ZZ, Fang J, Wang	Nat Med	2018	1
Pharmacological and bioinformatics analysis reveals the reno-protective mechanis [PMID:41270547]	["Ruiping L", "Yafeng W", "Liuyun L", "X	Computational biology and chem	2026	0
Hepatic Effects of Etoricoxib in Mice: Integrated Histopathological and Gene Exp [PMID:41901261]	["Jamous Y", "Alghamdi B", "Jarrar Y", "	Pharmaceuticals (Basel, Switze	2026	0
Androgen Receptor-Induced Lactoferrin Accelerates Prostate Tumorigenesis Through [PMID:41945871]	Liu C, Peng Q, Zhang X, Li Z, Wu Y et al	Adv Sci (Weinh)	2026	0
Association of TyG index and [PMID:41757381]	["Yin Y", "Yang M", "Deng W", "Zheng W"]	Journal of diabetes and metabo	2026	0
Luteolin alleviates ox-LDL-induced endothelial cell inflammation, apoptosis and [PMID:41633065]	["Yang B", "Zhang H", "Fang S", "Liu Y",	Molecular immunology	2026	0
Oroxylin A attenuates sepsis-associated coagulopathy by targeting the ALOX12-lip [PMID:41794265]	["Bai D", "Lu J", "Yang H", "Zhou C", "Z	Biochemical pharmacology	2026	0
Pan-PPAR agonist bezafibrate alleviates psoriasis by suppressing LCN2-dependent [PMID:41662914]	["Xin R", "Zhang J", "Zhang Y", "Dai M",	Free radical biology & medicin	2026	0
Sevoflurane exposure triggers ferroptosis of neuronal cells initiated by the act [PMID:40378436]	["Gu W", "Pan T", "Wang X", "Kang L", "L	International immunopharmacolo	2025	0
Typhae Pollen active subfraction exerts antiangiogenic effect in benign prostati [PMID:40934757]	Chen L, Chen D, Li J, Guo J, Lin M, Chen	Phytomedicine : international	2025	0
Resolution of experimental malaria-associated acute respiratory distress syndrom [PMID:40615878]	Prenen F, De Pauw B, Knoops S, Pollenus	Malaria journal	2025	0
Eicosanoid biosynthesizing enzymes in Prototheria. [PMID:39389415]	Kakularam KR, Gündem E, Stehling S, Roth	Biochimica et biophysica acta.	2025	0
Inhibition of ALOX12-12-HETE Alleviates Lung Ischemia-Reperfusion Injury by Redu [PMID:39268501]	["Li C", "Gao P", "Zhuang F", "Wang T",	Research (Washington, D.C.)	2024	0
The involvement of IRP2-induced ferroptosis through the p53-SLC7A11-ALOX12 pathw [PMID:38936518]	["Yao Z", "Jia F", "Wang S", "Jiao Q", "	Free radical biology & medicin	2024	0
Hydroperoxidation of Docosahexaenoic Acid by Human ALOX12 and pigALOX15-mini-LOX [PMID:37047037]	Canyelles-Niño M, González-Lafont À, Llu	International journal of molec	2023	0
Impact of pharmacogenetics on aspirin resistance: a systematic review. [PMID:36918009]	["Silva G", "Lopes B", "Moser V", "Ferre	Arquivos de neuro-psiquiatria	2023	0

ALOX12

Understanding Entity Pages

Summary

Wiki Pages (20)

neuroinflammation

Ferroptotic Neurons

Neuroinflammation Pathway

Music and Rhythm-Based Therapy for CBS/PSP

DNA Damage Response in Corticobasal Syndrome

Ferroptosis

Autophagy Enhancement for Tauopathy

Neuroinflammation in PD

Ferroptosis Therapy for Parkinson's Disease

Ferroptosis in Neurodegeneration

Ferroptosis Modulation Therapy

Microglia Modulation Therapies

Pyroptosis Inhibition Therapy

Glymphatic Waste Clearance Therapy for Parkinson's Disease

Neuroinflammation in Corticobasal Degeneration

Neuroinflammation in Corticobasal Syndrome

Pyroptosis Modulation Therapy

Neuroinflammation and Microglia Pathway in Alzheimer's Disease

ALOX15 - Arachidonate 15-Lipoxygenase