Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CARDIOMYOCYTES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CARDIOMYOCYTES |
| Key Genes/Proteins | NRF2, BDNF, AKT |
| Related Diseases | OXIDATIVE STRESS, ROS |
Knowledge base pages for this entity
graph TD
CARDIOMYOCYTES["CARDIOMYOCYTES"]
CARDIOMYOCYTES -->|"inhibits"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
CARDIOMYOCYTES -->|"activates"| FERROPTOSIS["FERROPTOSIS"]
CARDIOMYOCYTES -->|"activates"| STEM_CELLS["STEM CELLS"]
CARDIOMYOCYTES -->|"activates"| ISCHEMIA["ISCHEMIA"]
APOPTOSIS["APOPTOSIS"] -->|"activates"| CARDIOMYOCYTES
AUTOPHAGY["AUTOPHAGY"] -->|"causes"| CARDIOMYOCYTES
AGING["AGING"] -->|"regulates"| CARDIOMYOCYTES
BCL2["BCL2"] -->|"activates"| CARDIOMYOCYTES| Target | Relation | Type | Str |
|---|---|---|---|
| OXIDATIVE STRESS | inhibits | process | 0.80 |
| OXIDATIVE STRESS | causes | phenotype | 0.65 |
| NRF2 | regulates | gene | 0.65 |
| NRF2 | causes | gene | 0.65 |
| FERROPTOSIS | activates | process | 0.50 |
| FERROPTOSIS | regulates | process | 0.50 |
| FERROPTOSIS | implicated_in | process | 0.50 |
| FERROPTOSIS | inhibits | process | 0.50 |
| STEM CELLS | activates | cell_type | 0.50 |
| DOXORUBICIN | associated_with | drug | 0.50 |
| MELATONIN | associated_with | drug | 0.45 |
| RIBOSOME | associated_with | organelle | 0.45 |
| CANAGLIFLOZIN | associated_with | drug | 0.45 |
| ISCHEMIA | activates | disease | 0.35 |
| FERROPTOSIS | causes | process | 0.35 |
| FERROPTOSIS | protects_against | process | 0.35 |
| DIABETES | interacts_with | disease | 0.35 |
| SENESCENCE | regulates | process | 0.35 |
| IPSC | activates | cell_type | 0.35 |
| INFLAMMATION | interacts_with | process | 0.35 |
| CYTOKINES | inhibits | protein | 0.35 |
| ISCHEMIA | inhibits | disease | 0.35 |
| VEGF | inhibits | gene | 0.35 |
| DIABETES | activates | disease | 0.35 |
| STING | inhibits | gene | 0.35 |
| CGAS | inhibits | gene | 0.35 |
| STING | implicated_in | gene | 0.35 |
| GPX4 | implicated_in | gene | 0.35 |
| PI3K | activates | gene | 0.35 |
| PI3K/AKT SIGNALING | inhibits | process | 0.35 |
| HEART FAILURE | activates | disease | 0.35 |
| NRF2 SIGNALING | inhibits | process | 0.35 |
| HDAC3 | inhibits | gene | 0.35 |
| ROS | activates | protein | 0.35 |
| OXIDATIVE STRESS | activates | process | 0.35 |
| NF-KB | activates | gene | 0.35 |
| ERK | activates | gene | 0.35 |
| SIRT1 | interacts_with | gene | 0.35 |
| STEM CELLS | differentiates_to | cell_type | 0.35 |
| FERROPTOSIS | associated_with | process | 0.35 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOPTOSIS | activates | process | 0.65 |
| BDNF | produces | gene | 0.65 |
| AKT | causes | gene | 0.65 |
| ROS | treats | phenotype | 0.65 |
| OXIDATIVE STRESS | stabilizes | phenotype | 0.60 |
| APOPTOSIS | inhibits | process | 0.50 |
| ferroptosis | regulates | phenotype | 0.50 |
| CELL DEATH | regulates | concept | 0.50 |
| aging | associated_with | phenotype | 0.50 |
| Cellular Senescence | associated_with | cell_type | 0.50 |
| LMNA | activates | gene | 0.50 |
| Stem Cell | activates | cell_type | 0.50 |
| IPSC | activates | concept | 0.50 |
| GENE EXPRESSION | regulates | concept | 0.50 |
| CCL2 | inhibits | protein | 0.50 |
| ISCHEMIA | inhibits | disease | 0.50 |
| CYTOKINES | inhibits | concept | 0.50 |
| MTORC1 | inhibits | concept | 0.50 |
| PROINFLAMMATORY CYTOKINES | inhibits | concept | 0.50 |
| cardiomyopathy | activates | disease | 0.50 |
| PERK | activates | gene | 0.50 |
| Autophagy | activates | process | 0.50 |
| VEGF | activates | gene | 0.50 |
| GRP78 | activates | protein | 0.50 |
| DIABETES | activates | disease | 0.50 |
| Cardiac | activates | disease | 0.50 |
| DIABETES MELLITUS | activates | concept | 0.50 |
| Type 1 Diabetes | activates | disease | 0.50 |
| CGAS | inhibits | protein | 0.50 |
| STING | inhibits | gene | 0.50 |
| oxidative stress | inhibits | phenotype | 0.50 |
| ferroptosis | inhibits | phenotype | 0.50 |
| apoptosis | activates | process | 0.50 |
| PLEC | activates | gene | 0.50 |
| ALZHEIMER | activates | gene | 0.50 |
| Alzheimer'S Disease | activates | disease | 0.50 |
| Astrocytes | activates | cell_type | 0.50 |
| Heart Failure | activates | disease | 0.50 |
| disease | activates | disease | 0.50 |
| ALZHEIMER'S | activates | concept | 0.50 |
| HDAC3 | inhibits | gene | 0.50 |
| NRF2 | inhibits | gene | 0.50 |
| Cardiac | inhibits | disease | 0.50 |
| apoptosis | inhibits | process | 0.50 |
| RAGE | activates | gene | 0.50 |
| oxidative stress | activates | phenotype | 0.50 |
| NF-κB | activates | concept | 0.50 |
| SIRT1 | protects_against | gene | 0.50 |
| Stem Cell | associated_with | cell_type | 0.50 |
| ferroptosis | activates | phenotype | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||