Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Psoriasis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | AKT, GENES, INFLAMMATION, MTOR, PINK1, MITOPHAGY, MTDNA, CGAS |
| Therapeutic Agents | Formononetin, Bezafibrate |
| KG Connections | 252 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Psoriasis["<b>Psoriasis</b>"]
Pi3K_Akt["Pi3K/Akt"]
Psoriasis -->|"therapeutic_target"| Pi3K_Akt
Differentiation["Differentiation"]
Psoriasis -->|"activates"| Differentiation
Immune_Response["Immune Response"]
Psoriasis -->|"therapeutic_target"| Immune_Response
Inflammation{"Inflammation"}
Psoriasis -.->|"inhibits"| Inflammation
Mtor["Mtor"]
Psoriasis -->|"regulates"| Mtor
INFLAMMATION(["INFLAMMATION"])
INFLAMMATION -->|"regulates"| Psoriasis
Als{"Als"}
Als -->|"therapeutic_target"| Psoriasis
style Psoriasis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Sebaceous Glands | associated_with | cell_type | 0.85 |
| Pi3K/Akt | therapeutic_target | pathway | 0.70 |
| Differentiation | activates | pathway | 0.70 |
| Immune Response | therapeutic_target | pathway | 0.70 |
| Inflammation | inhibits | disease | 0.65 |
| Mtor | regulates | pathway | 0.60 |
| Mtor | treats | pathway | 0.60 |
| Pi3K/Akt | contributes_to | pathway | 0.60 |
| Nf-Κb | contributes_to | pathway | 0.60 |
| Mtor | implicated_in | pathway | 0.60 |
| Glycolysis | implicated_in | pathway | 0.60 |
| Jak-Stat | activates | pathway | 0.60 |
| Mitochondrial Function | causes | pathway | 0.60 |
| Mitophagy | causes | pathway | 0.60 |
| Interferon Signaling | causes | pathway | 0.60 |
| Nf-Κb | regulates | pathway | 0.60 |
| Jak-Stat | regulates | pathway | 0.60 |
| Adaptive Immunity | causes | pathway | 0.60 |
| Nf-Κb | inhibits | pathway | 0.60 |
| Immune Response | activates | pathway | 0.60 |
| Dysbiosis | regulates | pathway | 0.60 |
| Microbiota | regulates | pathway | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Cell Cycle | inhibits | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Necroptosis | activates | pathway | 0.60 |
| Apoptosis | therapeutic_target | pathway | 0.60 |
| Nf-Κb | therapeutic_target | pathway | 0.60 |
| Tgf-Β | therapeutic_target | pathway | 0.60 |
| Innate Immunity | treats | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| Adaptive Immunity | therapeutic_target | pathway | 0.60 |
| Adaptive Immunity | contributes_to | pathway | 0.60 |
| Immune Response | contributes_to | pathway | 0.60 |
| Inflammasome | contributes_to | pathway | 0.60 |
| Mtor | inhibits | pathway | 0.60 |
| Foxo Signaling | therapeutic_target | pathway | 0.60 |
| Autoimmune | activates | disease | 0.55 |
| Asthma | inhibits | disease | 0.55 |
| Inflammation | regulates | disease | 0.55 |
| Inflammation | therapeutic_target | disease | 0.55 |
| Autoimmune | therapeutic_target | disease | 0.55 |
| Chronic Kidney Disease | associated_with | disease | 0.55 |
| Obesity | treats | disease | 0.55 |
| Type 2 Diabetes | treats | disease | 0.55 |
| Insulin Resistance | treats | disease | 0.55 |
| Autoimmune | treats | disease | 0.55 |
| Autoimmune | contributes_to | disease | 0.55 |
| GENE EXPRESSION | expressed_in | concept | 0.50 |
| Proteins | expressed_in | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | regulates | gene | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| INFLAMMATION | inhibits | gene | 0.95 |
| Bezafibrate | treats | drug | 0.90 |
| keratinocyte hyperproliferation | drives | phenotype | 0.90 |
| Ferroptosis | contributes_to | process | 0.90 |
| Keratinocyte Hyperproliferation | associated_with | phenotype | 0.90 |
| Inflammation | regulates | disease | 0.85 |
| AKT | therapeutic_target | gene | 0.85 |
| PI3K | therapeutic_target | gene | 0.85 |
| INFLAMMATION | therapeutic_target | gene | 0.85 |
| TNF | therapeutic_target | gene | 0.85 |
| CYTOKINES | therapeutic_target | gene | 0.85 |
| TNF | activates | gene | 0.85 |
| Als | regulates | disease | 0.85 |
| Formononetin | treats | compound | 0.85 |
| T Cells | causes | cell_type | 0.85 |
| Keratinocyte Abnormal Growth | associated_with | phenotype | 0.85 |
| Sebaceous Glands | involved_in | cell_type | 0.85 |
| ferroptosis | contributes_to | process | 0.85 |
| LGALS3 | associated_with | gene | 0.80 |
| TNF | associated_with | gene | 0.80 |
| IL-10 | associated_with | gene | 0.80 |
| GAPDH | associated_with | gene | 0.80 |
| STAT3 | associated_with | gene | 0.80 |
| EGFR | associated_with | gene | 0.80 |
| ITGB1 | associated_with | gene | 0.80 |
| Sebaceous Glands | contributes_to | cell_type | 0.80 |
| TNF-Α | therapeutic_target | gene | 0.75 |
| TNF | inhibits | gene | 0.75 |
| GENES | activates | gene | 0.75 |
| JAK | activates | gene | 0.75 |
| Rheumatoid Arthritis | inhibits | disease | 0.75 |
| Als | inhibits | disease | 0.75 |
| TRPV4 | activates | gene | 0.75 |
| IFN | activates | gene | 0.75 |
| INFLAMMATION | activates | gene | 0.75 |
| INFLAMMATION | associated_with | gene | 0.75 |
| HIF | regulates | gene | 0.65 |
| MYC | regulates | gene | 0.65 |
| MTOR | regulates | gene | 0.65 |
| MTOR | treats | gene | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| PI3K | contributes_to | gene | 0.65 |
| CD14 | therapeutic_target | gene | 0.65 |
| NF-ΚB | contributes_to | gene | 0.65 |
| STAT1 | contributes_to | gene | 0.65 |
| INFLAMMATION | contributes_to | gene | 0.65 |
| CXCL10 | therapeutic_target | gene | 0.65 |
| AKT | contributes_to | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||