gene

MELK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MELK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

138Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

Summary

MELK (Maternal Embryonic Leucine Zipper Kinase) encodes a serine/threonine protein kinase involved in stem cell maintenance, cell cycle regulation, apoptosis, and implicated in Alzheimer's disease and cancer

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🧬 Gene Info

Gene Symbol	MELK
Full Name	Maternal Embryonic Leucine Zipper Kinase
Chromosome	9p13.2
Protein Type	Kinase
Function	encodes a serine/threonine protein kinase of the AMPK-related kinase family.
Primary Expression	Embryonic stem cells, neural progenitors, some neurons, many cancers
Molecular Weight	~75 kDa
Amino Acids	651 aa
Exons	14
Pathways	AMPK
UniProt ID	Q9Y2V2
NCBI Gene ID	9833
Ensembl ID	ENSG00000165304
OMIM	607025
GeneCards	MELK
Human Protein Atlas	MELK
Associated Diseases	CRC, Cancer, Colorectal Cancer, Inflammatory Bowel Disease, Tumor
Known Drugs/Compounds	rapamycin
Interactions	STAT3, CD8, NOD2, RIPK2, SMARCA4, BRG1
KG Connections	138 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MELK — AlphaFold Q9Y2V2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MELK["<b>MELK</b>"]
    Carcinoma{"Carcinoma"}
    MELK -->|"activates"| Carcinoma
    Als{"Als"}
    MELK -->|"inhibits"| Als
    Ms{"Ms"}
    MELK -->|"regulates"| Ms
    Tumor{"Tumor"}
    MELK -->|"activates"| Tumor
    STAT3["STAT3"]
    MELK -->|"activates"| STAT3
    CD8["CD8"]
    MELK -->|"activates"| CD8
    neurodegeneration["neurodegeneration"]
    MELK -->|"implicated in"| neurodegeneration
    style MELK fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (91)

Target	Relation	Type	Str
Carcinoma	activates	disease	0.65
Als	inhibits	disease	0.65
Ms	regulates	disease	0.65
Tumor	activates	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Inflammatory Bowel Disease	associated_with	disease	0.65
STAT3	activates	gene	0.60
CD8	activates	gene	0.60
TNF	associated_with	gene	0.60
RIPK3	associated_with	gene	0.60
NOD2	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60
ERN1	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
SMARCA4	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
ASC	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
Rb	associated_with	protein	0.60
Stat3	associated_with	protein	0.60
MTOR	activates	gene	0.60
PI3K	activates	gene	0.60
PYCARD	activates	gene	0.60
RIPK3	activates	gene	0.60
SQSTM1	activates	gene	0.60
TNF	activates	gene	0.60
TNFA	activates	gene	0.60
ULK1	activates	gene	0.60
CRC	associated_with	disease	0.60
RALGAPA2	activates	gene	0.60
SNF	activates	gene	0.60
SWI	activates	gene	0.60
ATG	associated_with	gene	0.60
ROS	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Stem Cell	associated_with	pathway	0.60
Mtor	associated_with	pathway	0.60
Microrna	associated_with	pathway	0.60
Mapk	associated_with	pathway	0.60
Unfolded Protein Response	associated_with	pathway	0.60
Epithelial	associated_with	cell_type	0.60
Dendritic Cell	associated_with	cell_type	0.60
AUTOPHAGY	associated_with	gene	0.60

Incoming (47)

Source	Relation	Type	Str
RIPK2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
TNFA	associated_with	gene	0.60
STAT3	associated_with	gene	0.60
ASC	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
BRG1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SMARCA4	associated_with	gene	0.60
PYCARD	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
RIPK3	associated_with	gene	0.60
NOD2	associated_with	gene	0.60
ERN1	associated_with	gene	0.60
BECLIN1	associated_with	gene	0.60
ASC	activates	gene	0.60
BRG1	activates	gene	0.60
LC3	activates	gene	0.60
IRGM1	activates	gene	0.60
CLDN2	activates	gene	0.60
MAP1LC3	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
ROS	associated_with	gene	0.60
NLR	associated_with	gene	0.60
NRBF2	associated_with	gene	0.60
MAPK	associated_with	gene	0.60
ATG	associated_with	gene	0.60
ATG	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MAPK	activates	gene	0.60
rapamycin	targets	drug	0.60
CCDC50	activates	gene	0.60
IKK	activates	gene	0.60
ULK1	activates	gene	0.50
TNFA	activates	gene	0.50
RIPK3	activates	gene	0.50
STAT3	activates	gene	0.50
BECN1	activates	gene	0.50
ERN1	activates	gene	0.50
SQSTM1	activates	gene	0.50
PYCARD	activates	gene	0.50
Pi3K	activates	pathway	0.50
Autophagy	activates	process	0.50
mTOR	activates	entity	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MELK

Understanding Entity Pages

Summary

Wiki Pages (5)

MELK Gene

STK11 Protein - LKB1 - Serine/Threonine Kinase 11

MELK Protein