concept

NITRIC OXIDE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NITRIC OXIDE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

125Connections

0Hypotheses

1Analyses

31Outgoing

50Incoming

0Experiments

1Debates

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💡 Concept Info

Name	NITRIC OXIDE
Key Genes/Proteins	AKT, CLU, GFAP, JNK
Related Diseases	AGING, INFLAMMATION, NEURODEGENERATION, OXIDATIVE STRESS

Pathway Diagram

graph TD
    NITRIC_OXIDE[NITRIC OXIDE]
    NITRIC_OXIDE -->|inhibits| Endothelial_Dysfunction[Endothelial Dysfunction]
    NITRIC_OXIDE -->|released_by| endothelial_cells[endothelial cells]
    NITRIC_OXIDE -->|modulates| Vascular_Remodelling[Vascular Remodelling]
    NITRIC_OXIDE -->|mediates| Antibacterial_Response[Antibacterial Response]
    NITRIC_OXIDE -->|mediates| Bacteria[Bacteria]
    NITRIC_OXIDE -->|released_by| astrocytes[astrocytes]
    NITRIC_OXIDE -->|released_by| macrophages[macrophages]
    NITRIC_OXIDE -->|phosphorylates| TAU[TAU]
    Asymmetric_Dimethyl_Arginine[Asymmetric Dimethyl Arginine] -->|inhibits| NITRIC_OXIDE
    SODs[SODs] -.protects against.-> NITRIC_OXIDE
    CREB[CREB] -->|activates| NITRIC_OXIDE
    ROS[ROS] -->|activates| NITRIC_OXIDE
    CLU[CLU] -->|inhibits| NITRIC_OXIDE
    AKT[AKT] -->|interacts| NITRIC_OXIDE
    TLR4[TLR4] -->|causes| NITRIC_OXIDE
    MICROGLIA[MICROGLIA] -->|produces| NITRIC_OXIDE

Outgoing (31)

Target	Relation	Type	Str
vasodilation	causes	process	0.90
Endothelial Dysfunction	inhibits	process	0.90
platelet aggregation	inhibits	process	0.90
endothelial cells	released_by	cell_type	0.90
Bacteria	mediates	organism	0.85
Antibacterial Response	mediates	process	0.85
Endothelial Dysfunction	protects_against	phenotype	0.85
Vascular Remodelling	modulates	process	0.85
astrocytes	released_by	cell_type	0.70
macrophages	released_by	cell_type	0.70
ASTROCYTES	treats	cell_type	0.65
NEURODEGENERATION	causes	disease	0.65
JNK	activates	gene	0.65
GFAP	activates	gene	0.65
CHOROID PLEXUS	inhibits	brain_region	0.65
TAU	phosphorylates	protein	0.65
TAU	exacerbates	protein	0.65
ASTROCYTES	causes	cell_type	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
OXIDATIVE STRESS	interacts_with	phenotype	0.65
INFLAMMATION	activates	phenotype	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
blood-brain barrier	active_in	brain_region	0.60
microglia	released_by	cell_type	0.60
neural stem cells	released_by	cell_type	0.60
ASTROCYTES	participates_in	cell_type	0.55
RAPAMYCIN	associated_with	drug	0.45
BRAINSTEM	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
PONS	associated_with	brain_region	0.45
METFORMIN	associated_with	drug	0.45

Incoming (94)

Source	Relation	Type	Str
Asymmetric Dimethyl Arginine	inhibits	compound	0.85
SODs	protects_against	protein	0.80
ROS	activates	gene	0.70
oxidative stress	inhibits	process	0.70
CREB	activates	gene	0.70
NOS3	regulates	gene	0.70
METFORMIN	treats	drug	0.65
AKT	interacts_with	gene	0.65
AKT	activates	gene	0.65
AKT	regulates	gene	0.65
CLU	inhibits	gene	0.65
MICROGLIA	produces	cell_type	0.65
AGING	interacts_with	phenotype	0.65
TLR4	causes	gene	0.65
SIRT3	activates	gene	0.60
ULK1	activates	gene	0.60
BECN1	activates	gene	0.60
PLIN2	activates	gene	0.60
GLP1R	regulates	gene	0.60
SIRT1	regulates	gene	0.60
TP53	regulates	gene	0.60
FOXO1	regulates	gene	0.60
SIRT3	regulates	gene	0.60
ULK1	regulates	gene	0.60
neurodegeneration	disrupts	disease	0.60
PRMT1	inhibits	gene	0.60
PRMT1	regulates	gene	0.60
CAV1	activates	gene	0.60
MMP2	activates	gene	0.60
spinal muscular atrophy	disrupts	disease	0.60
MTORC1	activates	gene	0.60
AMPK	activates	gene	0.60
ATG	activates	gene	0.60
MAP1LC3	activates	gene	0.60
RAS	activates	gene	0.60
MTORC1	regulates	gene	0.60
AMPK	regulates	gene	0.60
CREB	regulates	gene	0.60
ATG	regulates	gene	0.60
MAP1LC3	regulates	gene	0.60
RAS	regulates	gene	0.60
MAPK	causes	gene	0.60
Alzheimer's disease	disrupts	disease	0.60
ROS	inhibits	gene	0.60
MMP9	activates	gene	0.60
SREBF2	activates	gene	0.60
STX17	activates	gene	0.60
FOXO1	activates	gene	0.60
TLR	activates	gene	0.60
P53	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

endocrinology | 2026-04-13 | 2 hypotheses Top: 0.653

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Despite FDA warnings and a 315% increased erythrocytosis risk with TRT, the asso

closed · Rounds: 4 · Score: 0.83 · 2026-04-14

Related Research

Hypotheses and analyses mentioning NITRIC OXIDE in their description or question text

No additional research found