gene

GLAUCOMA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLAUCOMA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1047Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	GLAUCOMA
Aliases	Open-angle glaucoma, Angle-closure glaucoma
Age	Glaucoma prevalence increases exponentially with age, reflecting cumulative damage and reduced regenerative capacity.
Genetics	Family history increases risk 4-10 fold. Multiple susceptibility loci have been identified (MYOC, OPTN, WDR36, CAV1/CAV2).
Ethnicity	African and Hispanic populations have higher prevalence and earlier onset.
Central Corneal Thickness	Thinner corneas are associated with higher glaucoma risk.
Topical Medications	Prostaglandin analogs (latanoprost, bimatoprost), beta-blockers, alpha-agonists, carbonic anhydrase inhibitors
Laser Therapy	Selective laser trabeculoplasty (SLT)
Surgical	Trabeculectomy, tube shunts, MIGS (minimally invasive glaucoma surgery)
Associated Diseases	ALS, Aging, Alzheimer, Amyotrophic Lateral Sclerosis, Cancer
Interactions	SIRT6, PVALB, CYP46A1, ALZHEIMER, APOE, ASTROCYTES
KG Connections	514 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GLAUCOMA["GLAUCOMA"] -->|"associated"| PIEZO1["PIEZO1"]
    style PIEZO1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| STROKE["STROKE"]
    style STROKE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| NEURODEGENERATION["NEURODEGENERATION"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| NEUROINFLAMMATION["NEUROINFLAMMATION"]
    style NEUROINFLAMMATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| NLRP3["NLRP3"]
    style NLRP3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"regulates"| NEUROPROTECTION["NEUROPROTECTION"]
    style NEUROPROTECTION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GLAUCOMA["GLAUCOMA"] -->|"associated"| SIRT6["SIRT6"]
    style SIRT6 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AHR["AHR"] -.->|"inhibits"| GLAUCOMA["GLAUCOMA"]
    style AHR fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CFB["CFB"] -->|"activates"| GLAUCOMA["GLAUCOMA"]
    style CFB fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    DEPRESSION["DEPRESSION"] -->|"contributes to"| GLAUCOMA["GLAUCOMA"]
    style DEPRESSION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"implicated in"| GLAUCOMA["GLAUCOMA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    AXON["AXON"] -->|"associated"| GLAUCOMA["GLAUCOMA"]
    style AXON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    style GLAUCOMA fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (494)

Target	Relation	Type	Str
Complement, Inflammasome, and Microglial Crosstalk	associated_with	mechanism	0.95
Retinal Ganglion Cell Degeneration	causes	process	0.95
Vision Loss	causes	phenotype	0.95
Retinal Ganglion Cell	associated_with	cell_type	0.95
Retinal Ganglion Cell Loss	causes	phenotype	0.95
Optic Nerve Degeneration	causes	phenotype	0.95
Retinal Ganglion Cell Death	causes	process	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.85
Tryptophan Metabolism	associated_with	pathway	0.80
retinal ganglion cells	causes	cell_type	0.70
MAPK	associated_with	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
Neurodegeneration	inhibits	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ischemia	activates	disease	0.65
Glaucoma	regulates	disease	0.65
Senescence	activates	disease	0.65
Aging	activates	disease	0.65
Glaucoma	activates	disease	0.65
Inflammation	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
Aging	expressed_in	disease	0.65
Glaucoma	expressed_in	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Glaucoma	inhibits	disease	0.65
Inflammation	contributes_to	disease	0.65
Ischemia	contributes_to	disease	0.65
ALS	contributes_to	disease	0.65
Neurodegeneration	contributes_to	disease	0.65
Glaucoma	contributes_to	disease	0.65
Glaucoma	associated_with	disease	0.65
Macular Degeneration	associated_with	disease	0.65
Aging	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Glaucoma	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
ALS	protects_against	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Glaucoma	causes	disease	0.65
Neuroinflammation	causes	disease	0.65
Inflammation	causes	disease	0.65
Hypertension	inhibits	disease	0.65
Depression	contributes_to	disease	0.65
Anxiety	contributes_to	disease	0.65

Incoming (553)

Source	Relation	Type	Str
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	1.00
OPTN	risk_factor_for	gene	0.95
NEURODEGENERATION	associated_with	gene	0.95
OPTN	associated_with	gene	0.95
Retinal Ganglion Cell Loss	causes	process	0.95
Elevated Intraocular Pressure	risk_factor_for	phenotype	0.95
Microbiota	contributes_to	process	0.95
Redox Imbalance	contributes_to	process	0.95
family history	risk_factor_for	phenotype	0.90
AHR/RAGE Pathway	involved_in	pathway	0.90
Intraocular Pressure	risk_factor_for	biomarker	0.90
Neurodegeneration	involved_in	process	0.90
NLRP3 INFLAMMASOME	involved_in	protein	0.90
Neuroinflammation	involved_in	process	0.90
Gut Microbiota	protects_against	process	0.90
Complement-Nlrp3-Microglia Axis	causes	pathway	0.90
Lps-Tlr4 Pathway	involved_in	pathway	0.90
astrocyte network	therapeutic_target	cell_type	0.90
ocular hypertension	risk_factor_for	phenotype	0.90
Complement	contributes_to	pathway	0.90
Tryptophan Metabolites	protects_against	compound	0.88
Perivascular Niche	protects_against	process	0.88
Indoleacetic Acid	treats	compound	0.88
Aging	risk_factor_for	process	0.88
inflammatory factor release	promotes	process	0.85
Retinal Ganglion Cell Loss	biomarker_for	phenotype	0.85
NEURODEGENERATIVE DISEASES	associated_with	gene	0.85
Genetics	risk_factor_for	process	0.85
Age	risk_factor_for	biomarker	0.85
Neuroprotection	protects_against	process	0.85
AHR/RAGE Pathway	protects_against	pathway	0.85
Gut Microbiota	associated_with	process	0.85
C1Q	involved_in	protein	0.85
C3	involved_in	protein	0.85
C5	involved_in	protein	0.85
Indoleacetic Acid	therapeutic_target	compound	0.85
NLRP3	involved_in	protein	0.85
AhR	protects_against	protein	0.82
MTOR	therapeutic_target	gene	0.80
LPS-TLR4 pathway	upstream_of	pathway	0.80
dysbiosis	promotes	process	0.80
OPTN	genetic_marker_for	gene	0.80
vascular dysregulation	risk_factor_for	process	0.80
NPY	implicated_in	gene	0.80
APOE3	contributes_to	protein	0.80
Tryptophan Metabolism	involved_in	process	0.80
Intraocular Pressure Lowering	treats	process	0.80
Complement	associated_with	pathway	0.80
NLRP3 Inflammasome	associated_with	pathway	0.80
Microglia	associated_with	cell_type	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

GLAUCOMA

Understanding Entity Pages

Wiki Pages (21)

retinal-ganglion-cells-glaucoma

cbs-psp-daily-action-plan

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Neuroprotection Strategies in Neurodegeneration

Gene-Mechanism-Therapy Causal Chains

KarXT for Alzheimer's Disease Cognitive Impairment - MINDSET 2 (NCT06976203)

Section 233: Advanced Virtual Reality and Immersive Technology-Based Rehabilitation in CBS/PSP

NF-kB Signaling Pathway in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

KarXT+EC Phase 3 (NCT07011732): Enhanced Formulation for AD Agitation

ROCK1 Gene

FGF Signaling Pathway in Neurodegeneration

lmx1b

Complement-Mediated Synapse Loss

Kinesin-1 Heavy Chain Protein

EPG5 Gene - Ectopic P-Granules 5 Autophagy Tutor

LY03020 - Luye Pharma Phase 1 Trial

Retinal Biomarkers in Neurodegeneration

Diseases

rgs16

Glymphatic Transport Along the Optic Nerve