gene

FER

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

209Connections
21Hypotheses
30Analyses
50Outgoing
50Incoming

Summary

FER is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, treats. Associated with ALS, Als, Arthritis. Connected to 131 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolFER
Full NameFER Proto-Oncogene, Tyrosine Kinase
Chromosome5q31.2
Protein TypeReceptor
FunctionThe FER gene encodes a non-receptor tyrosine kinase (Fer) that belongs to the FPS/FES family of tyrosine kinases.
Primary Expressionthe brain and plays important roles in neuronal signaling, synaptic function, and cell adhesion[@fer2000]
PathwaysFerroptosis, Oxidative Stress
UniProt ID[P16591](https://www.uniprot.org/uniprot/P16591)
Ensembl IDENSG00000151422
GeneCardsFER
Human Protein AtlasFER
Associated DiseasesStroke
InteractionsNFE2L2, ALOX15, SOX9, MMP3, MMP1, HMOX1
KG Connections209 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

FER Gene

gene · 1009 words

metal-ion-synuclein-mitochondria-axis-parkinsons

general · 4097 words

Red Nucleus

brain · 1987 words

RedHill Biopharma Ltd.

company · 1786 words

Oligodendrocyte Precursor Cells (OPCs)

cell · 1537 words

Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease

experiment · 1334 words

Pathway Diagram

flowchart TD
    FER["FER"] -->|"activates"| Cancer["Cancer"]
    FER["FER"] -->|"activates"| Als["Als"]
    FER["FER"] -->|"activates"| Arthritis["Arthritis"]
    FER["FER"] -->|"associated with"| Stroke["Stroke"]
    FER["FER"] -->|"activates"| Parkinson["Parkinson"]
    FER["FER"] -->|"biomarker for"| Cardiac["Cardiac"]
    FER["FER"] -->|"therapeutic target"| Ms["Ms"]
    FER["FER"] -->|"biomarker for"| Inflammation["Inflammation"]
    FER["FER"] -->|"activates"| ALS["ALS"]
    FER["FER"] -->|"activates"| Ferroptosis["Ferroptosis"]
    FER["FER"] -.->|"inhibits"| Ferroptosis["Ferroptosis"]
    FER["FER"] -->|"activates"| NFE2L2["NFE2L2"]
    style FER fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Arthritis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ferroptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
    style NFE2L2 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (110)

TargetRelationTypeStr
Ferroptosisactivatespathway0.90
Canceractivatesdisease0.85
Ferroptosisinhibitspathway0.80
Tumorinhibitsdisease0.75
Inflammationactivatesdisease0.75

Incoming (99)

SourceRelationTypeStr
FERROPTOSISactivatesgene0.90
CANCERactivatesgene0.80
ROSactivatesgene0.80
FERROPTOSISinhibitsgene0.80
GPX4inhibitsgene0.70

Targeting Hypotheses (21)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro 0.662 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
Ferroptosis Inhibition for α-Synuclein Neuroprotection 0.548 neurodegeneration Gene expression changes in aging mouse b
Heterogeneous astrocyte activation states differentially imp 0.523 Alzheimer's disease SEA-AD Single-Cell Analysis: Cell-Type V
Vagal Afferent Microbial Signal Modulation 0.521 neurodegeneration What are the mechanisms by which gut mic
40 Hz Gamma Entrainment Gates ACSL4-Mediated Ferroptotic Pri 0.515 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
ACSL4-Ferroptotic Priming in Stressed Oligodendrocytes Drive 0.512 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
OPC differentiation blockade contributes to white matter deg 0.495 Alzheimer's disease SEA-AD Single-Cell Analysis: Cell-Type V
ACSL4-Driven Ferroptotic Priming in Disease-Associated Oligo 0.493 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Remodeling as the Primary Ferrop 0.493 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Sub 0.491 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
ALOX15-Driven Enzymatic Ferroptosis in AD Oligodendrocytes v 0.491 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
LPCAT3-Mediated Lands Cycle Amplification of Ferroptotic Vul 0.485 Alzheimer's Disease Cell type vulnerability in Alzheimers Di
Microglial Efferocytosis Enhancement via GPR32 Superagonists 0.483 neurodegeneration Neuroinflammation resolution mechanisms
Magnetosonic-Triggered Transferrin Receptor Clustering 0.470 neurodegeneration Blood-brain barrier transport mechanisms
Mitochondrial Transfer Pathway Enhancement 0.443 neurodegeneration Astrocyte reactivity subtypes in neurode
Differential Interneuron Optogenetic Restoration Therapy 0.430 neuroscience Circuit-level neural dynamics in neurode
CX43 hemichannel engineering enables size-selective mitochon 0.415 neurodegeneration Mitochondrial transfer between astrocyte
Biorhythmic Interference via Controlled Sleep Oscillations 0.412 neurodegeneration Microglia-astrocyte crosstalk amplificat
GAP43-mediated tunneling nanotube stabilization enhances neu 0.380 neurodegeneration Mitochondrial transfer between astrocyte
Optogenetic Control of Mitochondrial Transfer Networks 0.378 neurodegeneration Mitochondrial transfer between neurons a
Mitochondrial Calcium Buffering Enhancement via MCU Modulati 0.376 neurodegeneration Selective vulnerability of entorhinal co

Mentioning Analyses (30)

Scientific analyses that reference this entity

What are the specific molecular determinants that govern tau strain selection du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.636

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

What are the precise temporal dynamics of astrocyte ketone production decline du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586

Why does Metformin fail to delay CJD progression despite improving anti-aging ha

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
In Silico Pharmacogenomic Assessment of Glucagon-like Peptide-1 (GLP1) Agonists [PMID:39865816] Sharafshah A, Lewandrowski KU, Gold MS, Current neuropharmacology 2025 1
Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alc [PMID:38509197] ["Cruz B", "Vozella V", "Borgonetti V", Molecular psychiatry 2024 1
Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling. [PMID:39737892] ["Feetham CH", "Collabolletta V", "Worth Nature communications 2024 1
Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulati [PMID:40993092] Jiang H, Hu W, Yuan L Tohoku J Exp Med 2026 0
GPX4 promotes optic nerve regeneration and retinal ganglion cell neuroprotection [PMID:41485051] Yang M, Bian F, Feng X, Li L, Huang H et Mol Ther 2026 0
Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors. [PMID:41494530] Liu J, Cai X, Lin J, Zhang Z, Zhou Q et Cell 2026 0
Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways [PMID:41516398] Gromadzka G, Tarnacka B, Cieślik M Int J Mol Sci 2026 0
Ferroptosis in neurological diseases: moving towards therapeutic intervention. [PMID:41554903] Tuo QZ, Bush AI, Lei P Mol Psychiatry 2026 0
Fin(e)-tuning ferroptosis. [PMID:41576911] Szylo KJ, Dixon SJ Mol Cell 2026 0
GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression. [PMID:41663525] Liu G, Wang Y, Huang H, Wang J, Yang J e Cell Mol Immunol 2026 0
A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth s [PMID:41720096] Xia Z, Yang X, Samovich SN, Tyurina YY, Cell 2026 0
The crossroads of inflammation and oxidative stress: A review of the interplay b [PMID:41722697] Park WH Pharmacol Res 2026 0
Ferroptosis in Cerebral Ischemia/Reperfusion Injury: Mechanistic Drivers and The [PMID:41738060] Song C, Liu Z, Tang J, Huang Y Neuropsychiatr Dis Treat 2026 0
Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications [PMID:41826143] Chen X Trends Mol Med 2026 0
4-Octyl itaconate attenuates radiation-induced intestinal injury associated with [PMID:41936917] Zhang S, Yue T, Jin P, Zhang X, Huo Q et Free Radic Biol Med 2026 0
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] Gu X, Sun F, Li Y, Yang S, Li Y Int J Biol Macromol 2026 0
Co-Delivery of Ferrostatin-1 and M2 Macrophage-Derived Exosomal Signals via Engi [PMID:41944411] Hao W, Sun N, Xue R, Chang J, Pang X et ACS Appl Mater Interfaces 2026 0
Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell [PMID:41945797] Zhang Y, Wang X, Wu Y, Liu L, Nuerlan G Adv Sci (Weinh) 2026 0
Ferroptosis-related mechanisms in prion diseases provide insights into neurodege [PMID:41945998] Zayed M, Tayara H, Jeong BH Redox Biol 2026 0
[The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] Wu K, Wang N, Zhao D, Wei W, Zhang W et Zhejiang Da Xue Xue Bao Yi Xue 2026 0