Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FER: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
FER is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, treats. Associated with ALS, Als, Arthritis. Connected to 131 entities in the SciDEX knowledge graph.
| Gene Symbol | FER |
| Full Name | FER Proto-Oncogene, Tyrosine Kinase |
| Chromosome | 5q31.2 |
| Protein Type | Receptor |
| Function | The FER gene encodes a non-receptor tyrosine kinase (Fer) that belongs to the FPS/FES family of tyrosine kinases. |
| Primary Expression | the brain and plays important roles in neuronal signaling, synaptic function, and cell adhesion[@fer2000] |
| Pathways | Ferroptosis, Oxidative Stress |
| UniProt ID | [P16591](https://www.uniprot.org/uniprot/P16591) |
| Ensembl ID | ENSG00000151422 |
| GeneCards | FER |
| Human Protein Atlas | FER |
| Associated Diseases | Stroke |
| Interactions | NFE2L2, ALOX15, SOX9, MMP3, MMP1, HMOX1 |
| KG Connections | 209 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
FER["FER"] -->|"activates"| Cancer["Cancer"]
FER["FER"] -->|"activates"| Als["Als"]
FER["FER"] -->|"activates"| Arthritis["Arthritis"]
FER["FER"] -->|"associated with"| Stroke["Stroke"]
FER["FER"] -->|"activates"| Parkinson["Parkinson"]
FER["FER"] -->|"biomarker for"| Cardiac["Cardiac"]
FER["FER"] -->|"therapeutic target"| Ms["Ms"]
FER["FER"] -->|"biomarker for"| Inflammation["Inflammation"]
FER["FER"] -->|"activates"| ALS["ALS"]
FER["FER"] -->|"activates"| Ferroptosis["Ferroptosis"]
FER["FER"] -.->|"inhibits"| Ferroptosis["Ferroptosis"]
FER["FER"] -->|"activates"| NFE2L2["NFE2L2"]
style FER fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0
style Arthritis fill:#ef5350,stroke:#333,color:#e0e0e0
style Stroke fill:#ef5350,stroke:#333,color:#e0e0e0
style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
style Cardiac fill:#ef5350,stroke:#333,color:#e0e0e0
style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
style ALS fill:#ef5350,stroke:#333,color:#e0e0e0
style Ferroptosis fill:#1b5e20,stroke:#333,color:#e0e0e0
style NFE2L2 fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ferroptosis | activates | pathway | 0.90 |
| Cancer | activates | disease | 0.85 |
| Ferroptosis | inhibits | pathway | 0.80 |
| Tumor | inhibits | disease | 0.75 |
| Inflammation | activates | disease | 0.75 |
| Apoptosis | activates | pathway | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| Ferroptosis | treats | pathway | 0.70 |
| Arthritis | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Parkinson | activates | disease | 0.65 |
| Cardiac | biomarker_for | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Inflammation | biomarker_for | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Osteoarthritis | activates | disease | 0.65 |
| Fibrosis | treats | disease | 0.65 |
| Inflammation | treats | disease | 0.65 |
| Colorectal Cancer | activates | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Pulmonary Fibrosis | activates | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| Breast Cancer | activates | disease | 0.65 |
| Liver Cancer | activates | disease | 0.65 |
| Lung Cancer | activates | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Sepsis | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| ALS | regulates | disease | 0.65 |
| NFE2L2 | activates | gene | 0.60 |
| ALOX15 | activates | gene | 0.60 |
| SOX9 | activates | gene | 0.60 |
| MMP3 | activates | gene | 0.60 |
| MMP1 | activates | gene | 0.60 |
| HMOX1 | activates | gene | 0.60 |
| GPX4 | inhibits | gene | 0.60 |
| MMP1 | inhibits | gene | 0.60 |
| MMP3 | inhibits | gene | 0.60 |
| SLC7A11 | therapeutic_target | gene | 0.60 |
| SOX9 | inhibits | gene | 0.60 |
| HMGB1 | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| GPX4 | therapeutic_target | gene | 0.60 |
| ALOX12 | activates | gene | 0.60 |
| ALOX5 | activates | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| MTOR | contributes_to | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FERROPTOSIS | activates | gene | 0.90 |
| CANCER | activates | gene | 0.80 |
| ROS | activates | gene | 0.80 |
| FERROPTOSIS | inhibits | gene | 0.80 |
| GPX4 | inhibits | gene | 0.70 |
| SLC7A11 | activates | gene | 0.70 |
| TNF | activates | gene | 0.70 |
| GPX4 | activates | gene | 0.70 |
| APOPTOSIS | activates | gene | 0.70 |
| P53 | activates | gene | 0.70 |
| FERROPTOSIS | treats | gene | 0.70 |
| TNF-Α | activates | gene | 0.70 |
| ROS | inhibits | gene | 0.70 |
| INFLAMMATION | activates | gene | 0.70 |
| ALOX5 | activates | gene | 0.60 |
| HMOX1 | activates | gene | 0.60 |
| ALOX15 | activates | gene | 0.60 |
| ALOX12 | activates | gene | 0.60 |
| NFE2L2 | activates | gene | 0.60 |
| MMP3 | activates | gene | 0.60 |
| SOX9 | activates | gene | 0.60 |
| SLC7A11 | therapeutic_target | gene | 0.60 |
| MMP1 | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| NCOA4 | regulates | gene | 0.60 |
| GPX4 | regulates | gene | 0.60 |
| BNIP3 | activates | gene | 0.60 |
| BECN1 | therapeutic_target | gene | 0.60 |
| HIF1A | inhibits | gene | 0.60 |
| SIRT3 | treats | gene | 0.60 |
| BECN1 | activates | gene | 0.60 |
| SLC7A11 | treats | gene | 0.60 |
| GPX4 | treats | gene | 0.60 |
| SLC7A11 | inhibits | gene | 0.60 |
| TNF | inhibits | gene | 0.60 |
| STAT3 | inhibits | gene | 0.60 |
| STING | activates | gene | 0.60 |
| CGAS | activates | gene | 0.60 |
| SPR | activates | gene | 0.60 |
| ACSL4 | activates | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| GPX4 | therapeutic_target | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| VDAC1 | activates | gene | 0.60 |
| GPX4 | expressed_in | gene | 0.60 |
| BCL2 | activates | gene | 0.60 |
| SLC7A11 | expressed_in | gene | 0.60 |
| P38 | activates | gene | 0.60 |
| NCOA4 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.636
immunology | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645
neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| In Silico Pharmacogenomic Assessment of Glucagon-like Peptide-1 (GLP1) Agonists [PMID:39865816] | Sharafshah A, Lewandrowski KU, Gold MS, | Current neuropharmacology | 2025 | 1 |
| Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alc [PMID:38509197] | ["Cruz B", "Vozella V", "Borgonetti V", | Molecular psychiatry | 2024 | 1 |
| Brainstem BDNF neurons are downstream of GFRAL/GLP1R signalling. [PMID:39737892] | ["Feetham CH", "Collabolletta V", "Worth | Nature communications | 2024 | 1 |
| Targeting the SCP2/HSPB1 Axis: A Novel Mechanism Underlying Ferroptosis Regulati [PMID:40993092] | Jiang H, Hu W, Yuan L | Tohoku J Exp Med | 2026 | 0 |
| GPX4 promotes optic nerve regeneration and retinal ganglion cell neuroprotection [PMID:41485051] | Yang M, Bian F, Feng X, Li L, Huang H et | Mol Ther | 2026 | 0 |
| Extracellular GPX4 impairs antitumor immunity via dendritic ZP3 receptors. [PMID:41494530] | Liu J, Cai X, Lin J, Zhang Z, Zhou Q et | Cell | 2026 | 0 |
| Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways [PMID:41516398] | Gromadzka G, Tarnacka B, Cieślik M | Int J Mol Sci | 2026 | 0 |
| Ferroptosis in neurological diseases: moving towards therapeutic intervention. [PMID:41554903] | Tuo QZ, Bush AI, Lei P | Mol Psychiatry | 2026 | 0 |
| Fin(e)-tuning ferroptosis. [PMID:41576911] | Szylo KJ, Dixon SJ | Mol Cell | 2026 | 0 |
| GPX4-dependent ferroptosis governs ILC2 homeostasis and colitis progression. [PMID:41663525] | Liu G, Wang Y, Huang H, Wang J, Yang J e | Cell Mol Immunol | 2026 | 0 |
| A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth s [PMID:41720096] | Xia Z, Yang X, Samovich SN, Tyurina YY, | Cell | 2026 | 0 |
| The crossroads of inflammation and oxidative stress: A review of the interplay b [PMID:41722697] | Park WH | Pharmacol Res | 2026 | 0 |
| Ferroptosis in Cerebral Ischemia/Reperfusion Injury: Mechanistic Drivers and The [PMID:41738060] | Song C, Liu Z, Tang J, Huang Y | Neuropsychiatr Dis Treat | 2026 | 0 |
| Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications [PMID:41826143] | Chen X | Trends Mol Med | 2026 | 0 |
| 4-Octyl itaconate attenuates radiation-induced intestinal injury associated with [PMID:41936917] | Zhang S, Yue T, Jin P, Zhang X, Huo Q et | Free Radic Biol Med | 2026 | 0 |
| Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] | Gu X, Sun F, Li Y, Yang S, Li Y | Int J Biol Macromol | 2026 | 0 |
| Co-Delivery of Ferrostatin-1 and M2 Macrophage-Derived Exosomal Signals via Engi [PMID:41944411] | Hao W, Sun N, Xue R, Chang J, Pang X et | ACS Appl Mater Interfaces | 2026 | 0 |
| Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell [PMID:41945797] | Zhang Y, Wang X, Wu Y, Liu L, Nuerlan G | Adv Sci (Weinh) | 2026 | 0 |
| Ferroptosis-related mechanisms in prion diseases provide insights into neurodege [PMID:41945998] | Zayed M, Tayara H, Jeong BH | Redox Biol | 2026 | 0 |
| [The Chinese medicine Gandouling attenuates brain injury in hepatolenticular deg [PMID:41946579] | Wu K, Wang N, Zhao D, Wei W, Zhang W et | Zhejiang Da Xue Xue Bao Yi Xue | 2026 | 0 |