concept

PERICYTE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PERICYTE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

688Connections
1Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

PERICYTE is a concept in neurodegeneration research. Key relationships include: activates, co discussed, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 128 entities in the SciDEX knowledge graph.

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💡 Concept Info
NamePERICYTE
SummaryPage for Pericyte PDGFR-Beta Agonist for Neurovascular Rescue
Key Genes/ProteinsAMYLOID, AMYLOID-BETA, NEURODEGENERATION, PDGF
Related DiseasesNeurodegeneration, ALZHEIMER'S DISEASE, COGNITIVE DECLINE, OXIDATIVE STRESS
Linked Hypotheses1 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pericyte PDGFR-Beta Agonist for Neurovascular Rescue

idea · 1751 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

Corticobasal Syndrome (CBS)

disease · 11374 words

Novel Therapy Index

idea · 10647 words

nhp-validation-animal-model

general · 5820 words

neuroinflammation

mechanism · 5462 words

Pathway Diagram

graph TD
    PERICYTE["PERICYTE"]
    PERICYTE -->|"activates"| ALS["ALS"]
    PERICYTE -->|"contributes to"| Aging["Aging"]
    PERICYTE -->|"causes"| Alzheimer["Alzheimer"]
    PERICYTE -->|"contributes to"| Huntington["Huntington"]
    PERICYTE -->|"contributes to"| Dementia["Dementia"]
    PERICYTE -->|"activates"| CYTOKINES["CYTOKINES"]
    PERICYTE -->|"interacts"| ANGPT1["ANGPT1"]
    PERICYTE -->|"interacts"| Pi3K_Akt["Pi3K/Akt"]
    PERICYTE -->|"activates"| Glycolysis["Glycolysis"]
    CD36["CD36"] -->|"regulates"| PERICYTE
    PI3K["PI3K"] -->|"interacts"| PERICYTE
    AKT["AKT"] -->|"interacts"| PERICYTE
    AMYLOID["AMYLOID"] -->|"activates"| PERICYTE
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"contributes to"| PERICYTE
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"contributes to"| PERICYTE
    BLOOD_BRAIN_BARRIER_DYSFUNCTIO["BLOOD-BRAIN BARRIER DYSFUNCTION"] -->|"contributes to"| PERICYTE
    APOE4["APOE4"] -->|"activates"| PERICYTE
    ALZHEIMER["ALZHEIMER"] -->|"causes"| PERICYTE

Outgoing (268)

TargetRelationTypeStr
Neurodegenerationactivatesdisease0.75
AMYLOIDactivatesgene0.70
ENDOTHELIAL CELLSproducescell_type0.70
ENDOTHELIAL CELLSinteracts_withcell_type0.70
AMYLOID-BETAdestabilizesprotein0.70

Incoming (420)

SourceRelationTypeStr
NEURODEGENERATIONactivatesgene0.70
PDGFtreatsgene0.70
OXIDATIVE STRESSactivatesphenotype0.70
APPregulatesgene0.70
SPINAL CORDinhibitsbrain_region0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Pericyte Contractility Reset via Selective PDGFR-β Agonism 0.443 neurodegeneration Perivascular spaces and glymphatic clear

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does pericyte senescence mechanistically promote glioma cell growth and inva

neurodegeneration | 2026-04-14 | 0 hypotheses

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726] Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu Cell Stem Cell 2025 1
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043] Kempuraj D, Dourvetakis KD, Cohen J, Val Front Cell Neurosci 2024 1
The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066] Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T Int J Mol Sci 2023 1
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] Calvier L, Herz J, Hansmann G JACC Basic Transl Sci 2022 1
Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333] Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z Nature 2021 1
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954] Montagne A, Nation DA, Sagare AP, Barisa Nature 2020 1
Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990] Keller A Annual review of physiology 2026 0
A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033] Levey J, Howe M, Douglas K, Odame E, Raj bioRxiv : the preprint server 2026 0
Immunological mechanisms and therapeutic approaches in pulmonary fibrosis. [PMID:41951242] Nell LM, Hendriks RW, Wijsenbeek MS, Cor Eur Respir Rev 2026 0
Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and T [PMID:41884335] Fu X, Fan J, Chen H, Zheng Y, Liu Y, Zha Research (Washington, D.C.) 2026 0
Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129] Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu Clinical & experimental ophtha 2026 0
Central nervous system pericytes express soluble ST2 in inflammation and injury. [PMID:41857656] Jansson D, Highet B, Li S, Stevenson TJ, Molecular brain 2026 0
Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235] Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn Pathology international 2026 0
The role of endothelial cell-pericyte interactions in vascularization and diseas [PMID:38246244] Li G, Gao J, Ding P, Gao Y Journal of advanced research 2025 0
Pericytes in Brain Homeostasis: Developmental Roles and Adult Functions. [PMID:41351407] Drozd U, Vechkapova S, Lanshakov D Frontiers in bioscience (Landm 2025 0
Pericyte-derived fibrotic scarring is conserved across diverse central nervous s [PMID:34535655] Dias DO, Kalkitsas J, Kelahmetoglu Y, Es Nature communications 2021 0
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfuncti [PMID:30643288] Nation DA, Sweeney MD, Montagne A, Sagar Nature medicine 2019 0
Pericytes in Primary Familial Brain Calcification. [PMID:31147881] Zarb Y, Franzoso FD, Keller A Advances in experimental medic 2019 0
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. [PMID:29502968] Dias DO, Kim H, Holl D, Werne Solnestam Cell 2018 0
Clarifying off-target effects for torcetrapib using network pharmacology and rev [PMID:23228038] ["Fan S", "Geng Q", "Pan Z", "Li X", "Ti BMC systems biology 2012 0