Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PERICYTE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PERICYTE is a concept in neurodegeneration research. Key relationships include: activates, co discussed, associated with. Associated with ALS, ALZHEIMER, ALZHEIMER'S. Connected to 128 entities in the SciDEX knowledge graph.
| Name | PERICYTE |
| Summary | Page for Pericyte PDGFR-Beta Agonist for Neurovascular Rescue |
| Key Genes/Proteins | AMYLOID, AMYLOID-BETA, NEURODEGENERATION, PDGF |
| Related Diseases | Neurodegeneration, ALZHEIMER'S DISEASE, COGNITIVE DECLINE, OXIDATIVE STRESS |
| Linked Hypotheses | 1 hypotheses |
Knowledge base pages for this entity
graph TD
PERICYTE["PERICYTE"]
PERICYTE -->|"activates"| ALS["ALS"]
PERICYTE -->|"contributes to"| Aging["Aging"]
PERICYTE -->|"causes"| Alzheimer["Alzheimer"]
PERICYTE -->|"contributes to"| Huntington["Huntington"]
PERICYTE -->|"contributes to"| Dementia["Dementia"]
PERICYTE -->|"activates"| CYTOKINES["CYTOKINES"]
PERICYTE -->|"interacts"| ANGPT1["ANGPT1"]
PERICYTE -->|"interacts"| Pi3K_Akt["Pi3K/Akt"]
PERICYTE -->|"activates"| Glycolysis["Glycolysis"]
CD36["CD36"] -->|"regulates"| PERICYTE
PI3K["PI3K"] -->|"interacts"| PERICYTE
AKT["AKT"] -->|"interacts"| PERICYTE
AMYLOID["AMYLOID"] -->|"activates"| PERICYTE
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"contributes to"| PERICYTE
NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"] -->|"contributes to"| PERICYTE
BLOOD_BRAIN_BARRIER_DYSFUNCTIO["BLOOD-BRAIN BARRIER DYSFUNCTION"] -->|"contributes to"| PERICYTE
APOE4["APOE4"] -->|"activates"| PERICYTE
ALZHEIMER["ALZHEIMER"] -->|"causes"| PERICYTE| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration | activates | disease | 0.75 |
| AMYLOID | activates | gene | 0.70 |
| ENDOTHELIAL CELLS | produces | cell_type | 0.70 |
| ENDOTHELIAL CELLS | interacts_with | cell_type | 0.70 |
| AMYLOID-BETA | destabilizes | protein | 0.70 |
| AMYLOID-BETA | causes | protein | 0.70 |
| SPINAL CORD | activates | brain_region | 0.70 |
| SPINAL CORD | causes | brain_region | 0.70 |
| ALZHEIMER'S DISEASE | exacerbates | disease | 0.70 |
| AMYLOID | destabilizes | protein | 0.70 |
| COGNITIVE DECLINE | protects_against | phenotype | 0.70 |
| COGNITIVE DECLINE | stabilizes | phenotype | 0.70 |
| TAU | associated_with | gene | 0.65 |
| ALS | activates | disease | 0.65 |
| Aging | contributes_to | disease | 0.65 |
| Alzheimer | causes | disease | 0.65 |
| ALS | contributes_to | disease | 0.65 |
| Huntington | contributes_to | disease | 0.65 |
| Dementia | contributes_to | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Alzheimer | activates | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Neuroinflammation | activates | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Coronary Artery Disease | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Alzheimer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Traumatic Brain Injury | regulates | disease | 0.65 |
| Huntington | regulates | disease | 0.65 |
| Epilepsy | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Multiple Sclerosis | regulates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | regulates | disease | 0.65 |
| Stroke | regulates | disease | 0.65 |
| PERICYTES | causes | cell_type | 0.65 |
| PERICYTES | regulates | cell_type | 0.65 |
| PERICYTES | activates | cell_type | 0.65 |
| VEGF | activates | gene | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Als | contributes_to | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Senescence | activates | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Stroke | inhibits | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | activates | gene | 0.70 |
| PDGF | treats | gene | 0.70 |
| OXIDATIVE STRESS | activates | phenotype | 0.70 |
| APP | regulates | gene | 0.70 |
| SPINAL CORD | inhibits | brain_region | 0.70 |
| PDGF | causes | gene | 0.70 |
| PDGF | stabilizes | gene | 0.70 |
| PDGF | regulates | gene | 0.70 |
| APOPTOSIS | associated_with | gene | 0.65 |
| AMYLOID | associated_with | gene | 0.65 |
| NEURODEGENERATION | associated_with | concept | 0.65 |
| APP | associated_with | gene | 0.65 |
| NEUROINFLAMMATION | associated_with | concept | 0.65 |
| GLIOMA | causes | disease | 0.65 |
| GLIOMA | contributes_to | disease | 0.65 |
| ASTROCYTE | activates | cell_type | 0.65 |
| ASTROCYTES | activates | cell_type | 0.65 |
| ALZHEIMER | stabilizes | disease | 0.65 |
| APOE | stabilizes | gene | 0.65 |
| APOE4 | stabilizes | gene | 0.65 |
| OLIGODENDROCYTE | impairs | cell_type | 0.65 |
| OLIGODENDROCYTES | impairs | cell_type | 0.65 |
| NEURON | regulates | cell_type | 0.65 |
| NEURONS | regulates | cell_type | 0.65 |
| ALZHEIMER | exacerbates | disease | 0.65 |
| CYTOKINES | produces | phenotype | 0.65 |
| MAPK | inhibits | gene | 0.65 |
| LYSOSOMAL DYSFUNCTION | causes | phenotype | 0.65 |
| CORTEX | interacts_with | brain_region | 0.65 |
| LYSOSOMAL DYSFUNCTION | inhibits | phenotype | 0.65 |
| AMPK | activates | gene | 0.65 |
| APOE | regulates | gene | 0.65 |
| AQP4 | produces | gene | 0.65 |
| AKT | co_discussed | gene | 0.60 |
| AMYLOID | co_discussed | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| DEMENTIA | associated_with | gene | 0.60 |
| HUNTINGTON | associated_with | gene | 0.60 |
| PI3K | interacts_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| AMYLOID | activates | gene | 0.60 |
| ALZHEIMER'S DISEASE | contributes_to | gene | 0.60 |
| NEURODEGENERATIVE DISORDERS | contributes_to | gene | 0.60 |
| BLOOD-BRAIN BARRIER DYSFUNCTION | contributes_to | gene | 0.60 |
| APOE4 | activates | gene | 0.60 |
| ALZHEIMER | causes | gene | 0.60 |
| TAU PATHOLOGY | contributes_to | gene | 0.60 |
| ANGPT1 | interacts_with | gene | 0.60 |
| CYTOKINES | activates | gene | 0.60 |
| ENDOTHELIAL | contributes_to | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Pericyte Contractility Reset via Selective PDGFR-β Agonism | 0.443 | neurodegeneration | Perivascular spaces and glymphatic clear |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726] | Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu | Cell Stem Cell | 2025 | 1 |
| Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043] | Kempuraj D, Dourvetakis KD, Cohen J, Val | Front Cell Neurosci | 2024 | 1 |
| The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066] | Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T | Int J Mol Sci | 2023 | 1 |
| Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044] | Calvier L, Herz J, Hansmann G | JACC Basic Transl Sci | 2022 | 1 |
| Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333] | Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z | Nature | 2021 | 1 |
| APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954] | Montagne A, Nation DA, Sagare AP, Barisa | Nature | 2020 | 1 |
| Pathophysiology of Primary Familial Brain Calcification. [PMID:41212990] | Keller A | Annual review of physiology | 2026 | 0 |
| A FZD4/LRP5 agonist restores pericyte coverage and vascular integrity by increas [PMID:41890033] | Levey J, Howe M, Douglas K, Odame E, Raj | bioRxiv : the preprint server | 2026 | 0 |
| Immunological mechanisms and therapeutic approaches in pulmonary fibrosis. [PMID:41951242] | Nell LM, Hendriks RW, Wijsenbeek MS, Cor | Eur Respir Rev | 2026 | 0 |
| Nano-Enabled Fluorescence Switching: A Novel Strategy for PDGFRβ Detection and T [PMID:41884335] | Fu X, Fan J, Chen H, Zheng Y, Liu Y, Zha | Research (Washington, D.C.) | 2026 | 0 |
| Loss of Pericyte Exacerbates Alzheimer's Disease-Associated Retinal Pathology. [PMID:41814129] | Hai-Chao C, Fu-Lin G, Jia-Xin C, Yi-Shu | Clinical & experimental ophtha | 2026 | 0 |
| Central nervous system pericytes express soluble ST2 in inflammation and injury. [PMID:41857656] | Jansson D, Highet B, Li S, Stevenson TJ, | Molecular brain | 2026 | 0 |
| Astrocyte-Glioblastoma Stem Cell Interactions via Extracellular Vesicles Contrib [PMID:41712235] | Shirai Y, Tsuda M, Wang L, Oda Y, Sugizn | Pathology international | 2026 | 0 |
| The role of endothelial cell-pericyte interactions in vascularization and diseas [PMID:38246244] | Li G, Gao J, Ding P, Gao Y | Journal of advanced research | 2025 | 0 |
| Pericytes in Brain Homeostasis: Developmental Roles and Adult Functions. [PMID:41351407] | Drozd U, Vechkapova S, Lanshakov D | Frontiers in bioscience (Landm | 2025 | 0 |
| Pericyte-derived fibrotic scarring is conserved across diverse central nervous s [PMID:34535655] | Dias DO, Kalkitsas J, Kelahmetoglu Y, Es | Nature communications | 2021 | 0 |
| Blood-brain barrier breakdown is an early biomarker of human cognitive dysfuncti [PMID:30643288] | Nation DA, Sweeney MD, Montagne A, Sagar | Nature medicine | 2019 | 0 |
| Pericytes in Primary Familial Brain Calcification. [PMID:31147881] | Zarb Y, Franzoso FD, Keller A | Advances in experimental medic | 2019 | 0 |
| Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. [PMID:29502968] | Dias DO, Kim H, Holl D, Werne Solnestam | Cell | 2018 | 0 |
| Clarifying off-target effects for torcetrapib using network pharmacology and rev [PMID:23228038] | ["Fan S", "Geng Q", "Pan Z", "Li X", "Ti | BMC systems biology | 2012 | 0 |