concept

IL-13

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-13: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

162Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	IL-13
Key Genes/Proteins	Npy1r
Related Diseases	Atopic Dermatitis, Inflammation, ALS, Als, Atherosclerosis
Related Pathways	JAK/STAT6

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IL_13["IL-13"]
    style IL_13 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IL_13 -->|"causes"| Atopic_Dermatitis["Atopic Dermatitis"]
    IL_13 -->|"mediates"| Type_2_Inflammation["Type 2 Inflammation"]
    IL_13 -->|"upregulates"| Npy1r([Npy1r])
    IL_13 -->|"activates"| JAK_STAT6["JAK/STAT6"]
    IL_13 -->|"activates"| INFLAMMATION["INFLAMMATION"]
    IL_13 -->|"activates"| Inflammation["Inflammation"]
    IL_13 -.->|"inhibits"| ALS["ALS"]
    IL_13 -.->|"inhibits"| Als["Als"]
    IL_13 -->|"expressed in"| Atherosclerosis["Atherosclerosis"]
    Tralokinumab{"Tralokinumab"} -.->|"inhibits"| IL_13
    IL_10([IL-10]) -->|"activates"| IL_13
    INFLAMMATION -->|"activates"| IL_13
    MITOCHONDRIAL_DYSFUNCTION([MITOCHONDRIAL DYSFUNCTION]) -->|"activates"| IL_13
    AND([AND]) -->|"activates"| IL_13
    MIRO1([MIRO1]) -->|"activates"| IL_13
    CLDN1([CLDN1]) -.->|"inhibits"| IL_13
    ARNT([ARNT]) -->|"activates"| IL_13
    AHR([AHR]) -->|"activates"| IL_13
    NRF2([NRF2]) -->|"activates"| IL_13

Outgoing (108)

Target	Relation	Type	Str
Atopic Dermatitis	causes	disease	0.90
Type 2 Inflammation	mediates	process	0.90
Npy1r	upregulates	gene	0.85
JAK/STAT6	activates	pathway	0.85
Inflammation	activates	disease	0.65
ALS	inhibits	disease	0.65
Als	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Atherosclerosis	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Multiple Sclerosis	activates	disease	0.65
Als	regulates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Als	causes	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	biomarker_for	disease	0.65
ALS	regulates	disease	0.65
ALS	causes	disease	0.65
Inflammation	causes	disease	0.65
Tgf-Β	activates	pathway	0.60
OCLN	expressed_in	gene	0.60
CLDN1	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
CLDN1	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60
ALZHEIMER	activates	gene	0.60
IL-1	regulates	gene	0.60
IL-6	activates	gene	0.60
BCL-2	activates	gene	0.60
MICROGLIA	activates	gene	0.60
MAPK	activates	gene	0.60
BAX	activates	gene	0.60
P38	activates	gene	0.60
PARKINSON	activates	gene	0.60
CYTOKINES	regulates	gene	0.60
Mapk	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60
Microglia	activates	cell_type	0.60
Neuron	activates	cell_type	0.60
CYTOKINES	causes	gene	0.60
Neuron	causes	cell_type	0.60
ISG15	inhibits	gene	0.60
FGF10	inhibits	gene	0.60
Nf-Κb	inhibits	pathway	0.60
Immune Response	inhibits	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
Macrophage	inhibits	cell_type	0.60
Monocyte	inhibits	cell_type	0.60
Fibroblast	inhibits	cell_type	0.60

Incoming (54)

Source	Relation	Type	Str
Tralokinumab	inhibits	drug	0.95
PNS-R1	downregulates	compound	0.90
DHT	upregulates	compound	0.80
DHT	modulates	compound	0.75
IL-10	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
AND	activates	gene	0.60
MIRO1	activates	gene	0.60
CLDN1	inhibits	gene	0.60
ARNT	activates	gene	0.60
AHR	activates	gene	0.60
NRF2	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
STAT6	activates	gene	0.60
IL-4	inhibits	gene	0.60
CLDN4	expressed_in	gene	0.60
ROS	activates	gene	0.60
AND	inhibits	gene	0.60
JAK	inhibits	gene	0.60
OCLN	expressed_in	gene	0.60
IFNG	expressed_in	gene	0.60
IL22	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
S100A9	expressed_in	gene	0.60
IL31	expressed_in	gene	0.60
IL4R	expressed_in	gene	0.60
NPY	causes	gene	0.60
IL-1	causes	gene	0.60
RNA	causes	gene	0.60
NPY1R	causes	gene	0.60
IRF7	inhibits	gene	0.60
GENES	biomarker_for	gene	0.60
INFLAMMATION	biomarker_for	gene	0.60
CLDN1	expressed_in	gene	0.60
S100A8	expressed_in	gene	0.60
AND	biomarker_for	gene	0.60
NEUROINFLAMMATION	activates	gene	0.60
NF-ΚB	activates	gene	0.60
INFLAMMATION	causes	gene	0.60
STAT6	causes	gene	0.60
AND	causes	gene	0.60
JAK	causes	gene	0.60
INOS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
BCL-2	activates	gene	0.60
MAPK	activates	gene	0.60
IL-1	regulates	gene	0.60
MICROGLIA	activates	gene	0.60
P38	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IL-13

Understanding Entity Pages

Wiki Pages (20)

Microglial Cells — Cell Type Hierarchy

NF-kB Signaling Pathway in Neurodegeneration

Microglia Activation Mechanism

NF-κB Signaling in Neurodegeneration

Neuroinflammation Pathway

IL3 (Interleukin 3)

Section 132: Advanced Systems Immunology and Network Pharmacology in CBS/PSP

CCR8 Gene

Neuroimmune Dysfunction in Frontotemporal Dementia

IL13 — Interleukin 13

IL25 (Interleukin 25)

IL31 (Interleukin 31)

IL9 (Interleukin 9)

Microglial Polarization

STAT6 — Signal Transducer and Activator of Transcription 6

Natural Killer Cells in Parkinson's Disease

STAT4 Gene

Neuroprotective Microglia