protein

PSMA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PSMA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections
0Hypotheses
0Analyses
47Outgoing
24Incoming

Summary

PSMA3 is a protein involved in neurodegeneration research. Key relationships include: interacts with, therapeutic target, regulates. Associated with Alzheimer, Cancer, Huntington. Connected to 40 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolPSMA3
Full NameProteasome 20S Subunit Alpha 3
Chromosome14q23.1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight28.1 kDa
Amino Acids255 aa
PathwaysAutophagy, Proteasome
NCBI Gene ID5684
Ensembl IDENSG00000172863
GeneCardsPSMA3
Human Protein AtlasPSMA3
Protein ProductPSMA3 Protein
Complex Membership20S/26S ubiquitin-proteasome system
Disease RelevanceProteostasis vulnerability in Alzheimer's Disease, Parkinson's Disease, ALS
Associated DiseasesALS, Alzheimer, dementia, neurodegeneration
InteractionsSOX2, YWHAZ, HSP90AB1, ACTB, CDC42, ATP5A1
KG Connections71 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (11)

Knowledge base pages for this entity

Canonical Page

PSMA3 Gene

gene · 876 words

26S Proteasome

protein · 1744 words

DDX20 Gene (DEAD-Box Helicase 20 / Gemin3)

gene · 1600 words

RNA Binding Fox-1 Homolog 1 (RBFOX1)

gene · 1224 words

PSMA3 Protein

protein · 1155 words

Proteasome-Ubiquitin System Dysfunction Validation in Parkinson's Disease

experiment · 742 words

Pathway Diagram

graph TD
    PSMA3["<b>PSMA3</b>"]
    Parkinson{"Parkinson"}
    PSMA3 -->|"therapeutic target"| Parkinson
    Alzheimer{"Alzheimer"}
    PSMA3 -->|"therapeutic target"| Alzheimer
    Huntington{"Huntington"}
    PSMA3 -->|"therapeutic target"| Huntington
    Ms{"Ms"}
    PSMA3 -->|"therapeutic target"| Ms
    PSMA3 -->|"interacts with"| Ms
    Cancer{"Cancer"}
    PSMA3 -->|"expressed in"| Cancer
    Tumor{"Tumor"}
    PSMA3 -->|"expressed in"| Tumor
    SOX2["SOX2"]
    PSMA3 -->|"interacts with"| SOX2
    YWHAZ["YWHAZ"]
    PSMA3 -->|"interacts with"| YWHAZ
    HSP90AB1["HSP90AB1"]
    PSMA3 -->|"interacts with"| HSP90AB1
    ACTB["ACTB"]
    PSMA3 -->|"interacts with"| ACTB
    CDC42["CDC42"]
    PSMA3 -->|"interacts with"| CDC42
    CCT2["CCT2"]
    CCT2 -->|"interacts with"| PSMA3
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"therapeutic target"| PSMA3
    GFAP["GFAP"]
    GFAP -->|"interacts with"| PSMA3
    GRIA1["GRIA1"]
    GRIA1 -->|"interacts with"| PSMA3
    SNAP25["SNAP25"]
    SNAP25 -->|"interacts with"| PSMA3
    ACTG1["ACTG1"]
    ACTG1 -->|"interacts with"| PSMA3
    SNCA["SNCA"]
    SNCA -->|"interacts with"| PSMA3
    GAPDH["GAPDH"]
    GAPDH -->|"interacts with"| PSMA3
    MAPK1["MAPK1"]
    MAPK1 -->|"interacts with"| PSMA3
    style PSMA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (47)

TargetRelationTypeStr
Parkinsontherapeutic_targetdisease0.65
Alzheimertherapeutic_targetdisease0.65
Huntingtontherapeutic_targetdisease0.65
Mstherapeutic_targetdisease0.65
Msinteracts_withdisease0.65

Incoming (24)

SourceRelationTypeStr
CCT2interacts_withgene0.60
GFAPinteracts_withgene0.60
GRIA1interacts_withgene0.60
SNAP25interacts_withgene0.60
ACTG1interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found