Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PSMA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
PSMA3 is a protein involved in neurodegeneration research. Key relationships include: interacts with, therapeutic target, regulates. Associated with Alzheimer, Cancer, Huntington. Connected to 40 entities in the SciDEX knowledge graph.
| Gene Symbol | PSMA3 |
| Full Name | Proteasome 20S Subunit Alpha 3 |
| Chromosome | 14q23.1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 28.1 kDa |
| Amino Acids | 255 aa |
| Pathways | Autophagy, Proteasome |
| NCBI Gene ID | 5684 |
| Ensembl ID | ENSG00000172863 |
| GeneCards | PSMA3 |
| Human Protein Atlas | PSMA3 |
| Protein Product | PSMA3 Protein |
| Complex Membership | 20S/26S ubiquitin-proteasome system |
| Disease Relevance | Proteostasis vulnerability in Alzheimer's Disease, Parkinson's Disease, ALS |
| Associated Diseases | ALS, Alzheimer, dementia, neurodegeneration |
| Interactions | SOX2, YWHAZ, HSP90AB1, ACTB, CDC42, ATP5A1 |
| KG Connections | 71 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
PSMA3["<b>PSMA3</b>"]
Parkinson{"Parkinson"}
PSMA3 -->|"therapeutic target"| Parkinson
Alzheimer{"Alzheimer"}
PSMA3 -->|"therapeutic target"| Alzheimer
Huntington{"Huntington"}
PSMA3 -->|"therapeutic target"| Huntington
Ms{"Ms"}
PSMA3 -->|"therapeutic target"| Ms
PSMA3 -->|"interacts with"| Ms
Cancer{"Cancer"}
PSMA3 -->|"expressed in"| Cancer
Tumor{"Tumor"}
PSMA3 -->|"expressed in"| Tumor
SOX2["SOX2"]
PSMA3 -->|"interacts with"| SOX2
YWHAZ["YWHAZ"]
PSMA3 -->|"interacts with"| YWHAZ
HSP90AB1["HSP90AB1"]
PSMA3 -->|"interacts with"| HSP90AB1
ACTB["ACTB"]
PSMA3 -->|"interacts with"| ACTB
CDC42["CDC42"]
PSMA3 -->|"interacts with"| CDC42
CCT2["CCT2"]
CCT2 -->|"interacts with"| PSMA3
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
ALZHEIMER_S_DISEASE -->|"therapeutic target"| PSMA3
GFAP["GFAP"]
GFAP -->|"interacts with"| PSMA3
GRIA1["GRIA1"]
GRIA1 -->|"interacts with"| PSMA3
SNAP25["SNAP25"]
SNAP25 -->|"interacts with"| PSMA3
ACTG1["ACTG1"]
ACTG1 -->|"interacts with"| PSMA3
SNCA["SNCA"]
SNCA -->|"interacts with"| PSMA3
GAPDH["GAPDH"]
GAPDH -->|"interacts with"| PSMA3
MAPK1["MAPK1"]
MAPK1 -->|"interacts with"| PSMA3
style PSMA3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | therapeutic_target | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Huntington | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| Prion | therapeutic_target | disease | 0.65 |
| SOX2 | interacts_with | gene | 0.60 |
| YWHAZ | interacts_with | gene | 0.60 |
| HSP90AB1 | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| ATP5A1 | interacts_with | gene | 0.60 |
| SOD1 | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| PSMC1 | regulates | gene | 0.60 |
| AMBRA1 | regulates | gene | 0.60 |
| DDX20 | regulates | gene | 0.60 |
| KIF23 | associated_with | gene | 0.60 |
| KIF11 | associated_with | gene | 0.60 |
| DNM1L | biomarker_for | gene | 0.60 |
| GRIA1 | interacts_with | gene | 0.60 |
| MAPK1 | interacts_with | gene | 0.60 |
| ACTG1 | interacts_with | gene | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| SNAP25 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| FN1 | interacts_with | gene | 0.60 |
| Blood-Brain Barrier | therapeutic_target | pathway | 0.60 |
| Mapk | interacts_with | pathway | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| Proteasome | regulates | pathway | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Immune Response | interacts_with | pathway | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| COL1A1 | associated_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| GENES | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| ALS | associated_with | disease | 0.60 |
| dementia | associated_with | disease | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
| PSMD14 | interacts_with | gene | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| RBFOX1 | co_expressed_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CCT2 | interacts_with | gene | 0.60 |
| GFAP | interacts_with | gene | 0.60 |
| GRIA1 | interacts_with | gene | 0.60 |
| SNAP25 | interacts_with | gene | 0.60 |
| ACTG1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| GAPDH | interacts_with | gene | 0.60 |
| MAPK1 | interacts_with | gene | 0.60 |
| SOX2 | interacts_with | gene | 0.60 |
| SOD1 | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| HSP90AB1 | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| FOXA2 | interacts_with | gene | 0.60 |
| ATP5A1 | interacts_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | therapeutic_target | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| HUNTINGTON | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| PSMD14 | interacts_with | gene | 0.60 |
| FN1 | interacts_with | gene | 0.60 |
| ANO3 | co_expressed_with | gene | 0.50 |
| FOXA2 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||